Category: 14080-23-0

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14080-23-0, name is 2-Cyanopyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 14080-23-0

[0505] Synthesis of methyl pyrimidine-2-carboxylate:[0506] To a stirred solution of pyrimidine-2-carbonitrile (12.0 g, 114.28 mmol) in MeOH (20 mL) was added methanolic HC1 (180 mL) at 0 C and stirred for 16 h. After completion of starting material by TLC, the volatiles were evaporated under reduced pressure. The residue was neutralized with saturated NaHC03 solution and extracted with EtOAc. The combined organic layer was dried over sodium sulphate, filtered and concentrated in vacuo to obtain the crude product. The crude material was triturated with Hexane to afford methyl pyrimidine-2-carboxylate (10.0 g, crude) as yellow solid. 1H-NMR (DMSO-d6, 400 MHz): delta 9.08 (d, 2H), 7.76 (t, 1H), 3.92 (s, 3H); LC-MS: 94.32%; 139 (M++l) (column; Chromolith RP-18, (100×4.6 mm); RT 2.85 min. 5mM NH4OAc: ACN; 0.8 ml/min); TLC: 70% EtOAc/Hexane (Rf: 0.2).

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Reference:
Patent; ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory; WO2013/142269; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14080-23-0, name is 2-Cyanopyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2-Cyanopyrimidine

General procedure: The nitrile (or combination of two different nitriles) and zinc triate (0.05 eq to the total nitrile content) were combined. When this did not yield a clear solution this was achieved by shortly heating the mixture at 60 C or by the addition of a minimum amount of Et0H. When a clear solution was obtained hydrazine monohydrate (2 eq to the total nitrile content) was added at once and the mixture was stirred at 60 C for typically 16 h, after which the volatiles were removed in vacuo. A1. Oxidation of dihydrotetrazine precursor ([2H]-TZ) having NHBoc functionality: The crude mixture containing [2H]-TZ was divided between CHC13 and H90 and the aqueous layer was extracted with CHC13 (3x). The organic layer was dried with Na2SO4, filtrated and the volatiles were removed in vacuo. Thecrude [2H]-TZ was dissolved in CH2C12 and PhI(OAc)2 (1.5 eq) was added. The mixture was stirred at room temperature until HPLC-PDAIMS indicated full conversion of [2H]-TZ to TZ (typically 2 to 4 h).

With the rapid development of chemical substances, we look forward to future research findings about 14080-23-0.

Reference:
Patent; TAGWORKS PHARMACEUTICALS B .V.; ROBILLARD , Marc Stefan; VERSTEEGEN, Ronny Mathieu; ROSSIN, Raffaella; HOUBEN, Freek Johannes Maria; VAN KASTEREN, Sander Izaak; (261 pag.)WO2019/212356; (2019); A1;,
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Pyrimidine – Wikipedia

Application of 14080-23-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 14080-23-0, name is 2-Cyanopyrimidine. A new synthetic method of this compound is introduced below.

Sodium (40 mg) was dissolved in methanol (20 ml), 2-cyanopyrimidine 1 (0.685 g, 5 mmol) was added and the resulting mixture was stirred at room temperature for 1 h.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,14080-23-0, 2-Cyanopyrimidine, and friends who are interested can also refer to it.

Reference:
Article; Kopchuk, Dmitry S.; Chepchugov, Nikolay V.; Khasanov, Albert F.; Kovalev, Igor S.; Santra, Sougata; Nosova, Emiliya V.; Zyryanov, Grigory V.; Majee, Adinath; Rusinov, Vladimir L.; Chupakhin, Oleg N.; Tetrahedron Letters; vol. 57; 34; (2016); p. 3862 – 3865;,
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Pyrimidine – Wikipedia

Related Products of 14080-23-0, Adding some certain compound to certain chemical reactions, such as: 14080-23-0, name is 2-Cyanopyrimidine,molecular formula is C5H3N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14080-23-0.

To the flask was added 0.10g of 2cyanopyrimidine,12% by mass aqueous sodium hydroxide solution 13mL was stirred at 70 30 minutes. Of 1N dilutehydrochloric acid to pH ~ 3 by adding little by little and, by concentration of the resulting organic layer was extracted three times with 10mL of ethyl acetate, to give0.10g of Compound A218

According to the analysis of related databases, 14080-23-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; LG CHEMICAL CO., LTD; PARK, JONG HO; SAH, KONG CHUN; KIM, SUNG HYUN; BAEK, GYUNG LIM; RYU, CHANG HYUN; (91 pag.)KR2015/128789; (2015); A;,
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Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14080-23-0, name is 2-Cyanopyrimidine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 14080-23-0

l-(pyrimidin-2-yl)ethenone may be prepared as follows:A solution of pyrimidine-2-carbonitrile (75 g, 713.62 mmol) in THF (750 ml, 10 vol) was added dropwise to a solution of Methylmagnesium bromide (3.0M in diethylether) (357 ml, 1070.44 mmol) in THF (750 ml) at -5C. The resulting yellow suspension/solution was stirred at O0C overnight, and added to a rapidly stirred mixture of saturated ammonium chloride solution (750 ml) and 4M HCl (450 ml) at 5C, then pH adjusted to 1 with additional 2M HCl (5mL). The solution was warmed to 2O0C, stirred for 40 minutes, cooled to 00C then pH adjusted to 6.5-7 by addition of saturated K2CO3 solution (37.5 ml), warmed to 1O0C and separated. The aqueous phase was further extracted into ethyl acetate (5 x 750 ml). Sodium chloride was added to saturate the aqueous phase, which was extracted further into ethyl acetate (750 ml). The pH of the aqueous phase was adjusted to 7-8 by addition of saturated K2CO3 solution, and extracted further with ethyl acetate (3 x 750 ml). The combined organics were washed with saturated brine (750 ml), dried over MgSO4, filtered and concentrated in vacuo to give 78.9g of a brown solid. The crude product was purified by flash silica chromatography, elution in EtOAc. Pure fractions were evaporated to dryness to afford 1- (pyrimidin-2-yl)ethanone (65.Og, 74.6 %) as a yellow crystalline solid. 1H NMR (400.132 MHz, DMSO) delta 2.67 (3H, s), 7.72 (IH, t), 9.02 (2H, d); m/z (M+H)+, 123.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 14080-23-0, 2-Cyanopyrimidine.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/117051; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14080-23-0, name is 2-Cyanopyrimidine, the common compound, a new synthetic route is introduced below. Safety of 2-Cyanopyrimidine

a) 2-Aminomethyl-pyrimidine 66.2 g (0.63 mole) of 2-cyano-pyrimidine (Liebigs Ann. Chem. 1981, 333) in 1.9 1 of ethanol are hydrogenated in the presence of 130 ml of liquid ammonia and 5 g of Pd-C (5% Pd) at 20 C. and 5-10 bar of hydrogen. The catalyst is filtered off, the filtrate is concentrated and the residue is distilled. Yield: 48.8 g (71% of theory) Boiling point: 82 C./4 mbar

The synthetic route of 14080-23-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bayer Aktiengesellschaft; US5312823; (1994); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14080-23-0, name is 2-Cyanopyrimidine, molecular formula is C5H3N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 2-Cyanopyrimidine

Reference Example 2-1 To a mixed solution of 25 g of 2-pyrimidinecarbonitrile in 100 mL of acetic acid and 100 mL of ethyl acetate, 1 g of 10% palladium/carbon was added, and the mixture was stirred for 14 hours at room temperature in a hydrogen atmosphere at ambient pressure. The palladium/carbon was removed from the reaction mixture by filtration through Celite, and an operation of adding toluene to a residue obtained by distilling off the solvent, and concentrating the mixture, was repeated four times. MeCN was added to the obtained residue to solidify the residue, and the solids were collected by filtration, to obtain 15.7 g of 1-pyrimidin-2-ylmethylamine acetate as a colorless solid.1-Pyrimidin-2-ylmethylamine acetateNMR-DMSOd6:1.88 (3H, s), 3.91 (2H, brs), 4.1-5.3 (3H, m), 7.38 (1H, t, J=4.9 Hz), 8.78 (2H, d, J=4.9 Hz) EI: 109

With the rapid development of chemical substances, we look forward to future research findings about 14080-23-0.

Reference:
Patent; ASTELLAS PHARMA INC.; US2010/256152; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14080-23-0, name is 2-Cyanopyrimidine, molecular formula is C5H3N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C5H3N3

Methyl pyrimidine-2-carboxylate (11):A stirred solution of cyano 10 (1.01 g, 9.52 mmol) in methanolic HC1 (20 mL, 4N solution) was refluxed for 16 h and concentrated under reduced pressure; the residue was diluted with water and neutralized with sodium bicarbonate solution. The aqueous layer was extracted with 20% IPA/CH2CI2, dried over anhydrous Na2S04, filtered and concentrated under reduced pressure to afford ester 11 (0.43 g, 32.5%) as liquid.TLC: 100% EtOAc (Rf: 0.1)1H NMR (500MHz, CDC13): delta 8.96 (d, J = 5.0 Hz, 2H), 7.50 (t, J = 5.0 Hz, 1H), 4.08 (s, 3H). Mass (ESI): 139 (M++l).

With the rapid development of chemical substances, we look forward to future research findings about 14080-23-0.

Reference:
Patent; THERACRINE, INC.; SUN, Lijun; BARSOUM, James; WESTER, Ronald; WO2013/13238; (2013); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 14080-23-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14080-23-0, name is 2-Cyanopyrimidine, molecular formula is C5H3N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step-2:Preparation of 2-amidinopyrimidinium hydrochloride (II)2-Cyanopyrimidine (XIII) (5Og, 475.73 mmol) was added to the solution of sodium ethoxide (3.24g, 47.64 mmol) in methanol (500 ml) at -3 to O0C and was stirred for 8 hrs. The reaction mass was allowed to a temperature of 25-3O0C and treated with ammonium chloride (26.72g, 499.43 mmol) to yield 2-amidinopyrimidinium hydrochloride (II).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 14080-23-0, 2-Cyanopyrimidine.

Reference:
Patent; AUROBINDO PHARMA LIMITED; BRAJESH, Kumar, Sinha; KONDURU, Rajasekhara, Raju; BUDIDET, Shankar, Reddy; VADDI, Pandu, RangaRao; AMINUL, Islam; MEENAKSHISUNDERAM, Sivakumaran; WO2011/24056; (2011); A2;,
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Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.14080-23-0, name is 2-Cyanopyrimidine, molecular formula is C5H3N3, molecular weight is 105.0974, as common compound, the synthetic route is as follows.Application In Synthesis of 2-Cyanopyrimidine

To a stirring solution of 2-cyanopyrimidine (2.0 g, 19.0 mmol) in methanol (50 mL) were added 10%Pd/C (300 mg), 12 N HCI (1.5 mL) under 2 atmosphere. The reaction mixture was stirred under atmosphere (balloon pressure) at RT for 3 h. After consumption of the starting material (by TLC), the reaction mixture was filtered through a pad of celite and the pad was washed with methanol. Obtained filtrate was concentrated under reduced pressure to afford crude compound which was triturated with diethyl ether to obtained compound 2S-Y (1.2 g, 44%) as white solid. 1H-NMR: (500 MHz, DMSO-i): delta 8.87 (d, J= 5.0 Hz, 2H), 8.69 (br s, 2H), 7.52 (t, J= 5.0 Hz, 1H), 4.24 (s, 2H); Mass (ESI): 1 10.3 [M++l]

At the same time, in my other blogs, there are other synthetic methods of this type of compound,14080-23-0, 2-Cyanopyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; NAUREX, INC.; LOWE, John, A., III; KHAN, M., Amin; WO2014/120783; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia