Category: 14080-56-9

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.14080-56-9, name is Thieno[2,3-d]pyrimidin-4-amine, molecular formula is C6H5N3S, molecular weight is 151.19, as common compound, the synthetic route is as follows.Product Details of 14080-56-9

EXAMPLE 4 This Example illustrates the preparation of 4-isopropylaminothieno[2,3-d]pyrimidine (Compound No. 5) by an alternative procedure to that described in Examples 1 and 2. A mixture of sodium hydride (0.64 g, 100%), 4-aminothieno[2,3-d]pyrimidine (3.5 g) and dry dimethylformamide (25 ml) was stirred for fifteen minutes at <20, then treated with 2-iodopropane (3.5 ml). After stirring at <20 for ninety minutes, the reaction mixture was diluted with water and cooled in ice. The precipitate was washed with water, dried and recrystallized from acetonitrile to give the title compound (1.4 g, m.p. 225-6). At the same time, in my other blogs, there are other synthetic methods of this type of compound,14080-56-9, Thieno[2,3-d]pyrimidin-4-amine, and friends who are interested can also refer to it. Reference:
Patent; Imperial Chemical Industries Limited; US4146716; (1979); A;; ; Patent; ICI Australia Limited; US4196207; (1980); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.14080-56-9, name is Thieno[2,3-d]pyrimidin-4-amine, molecular formula is C6H5N3S, molecular weight is 151.19, as common compound, the synthetic route is as follows.Recommanded Product: 14080-56-9

EXAMPLE 4 This Example illustrates the preparation of 4-isopropylaminothieno[2,3-d]pyrimidine (Compound No. 5) by an alternative procedure to that described in Examples 1 and 2. A mixture of sodium hydride (0.64 g, 100%), 4-aminothieno[2,3-d]pyrimidine (3.5 g) and dry dimethylformamide (25 ml) was stirred for fifteen minutes at <20, then treated with 2-iodopropane (3.5 ml). After stirring at <20 for ninety minutes, the reaction mixture was diluted with water and cooled in ice. The precipitate was washed with water, dried and recrystallized from acetonitrile to give the title compound (1.4 g, m.p. 225-6). At the same time, in my other blogs, there are other synthetic methods of this type of compound,14080-56-9, Thieno[2,3-d]pyrimidin-4-amine, and friends who are interested can also refer to it. Reference:
Patent; Imperial Chemical Industries Limited; US4146716; (1979); A;; ; Patent; ICI Australia Limited; US4196207; (1980); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14080-56-9, name is Thieno[2,3-d]pyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows. category: pyrimidines

To a solution of 6-bromo-8-methyl-2H-spiro[imidazo[1 ,5-a]pyridine-3,3?-thietane]-l ,5-dione (prepared according to example 173a, 100 mg, 332 pmol) and thieno[2,3-d]pyrimidin-4- amine (GAS 14080-56-9, 55.2 mg, 365 pmol) in 1 ,4-dioxane (11 mL) was added cesiumcarbonate (20.6 mg, 35.5 pmol) and the mixture was degassed and purged with argon several times. 4,5-Bis(diphenylphosphino)-9,9-dimethylxanthene (16.9 mg, 35.5 pmol), 2- (dicyclohexyl-phosphino)-2,4, 6-triisopropylbiphenyl (7.98 mg, 35.5 pmol), palladium(ll)acetate (32.5 mg, 35.5 pmol) and tris(dibenzylideneacetone)dipalladium(0) (325 mg, 996 pmol) were added and the mixture was stirred at 100cC for 2 hours. Themixture was concentrated and the residue purified by flash chromatography (Biotage SNAP cartridge silica 25 g, ethanol: dichloromethane). The isolated product was taken up in ethanol and stirred at RT. The solid was filtered off under vacuo and dried to give 27.0 mg (21% yield) of the title compound.LG-MS: m/z = 372.2 [M÷H].1H-NMR (400 MHz, DMSO-d6) 6 [ppm]= 1.035 (0.63), 1.052 (1.21), 1.070 (0.63), 2.322(0.75), 2.327 (1.01), 2.331 (0.79), 2.447 (16.00), 2.522 (3.03), 2.665 (0.75), 2.669 (0.97),2.673 (0.74), 3.300 (3.97), 4.679 (3.83), 4.705 (3.78), 5.759 (0.60), 7.831 (2.67), 7.846(3.88), 7.908 (3.86), 7.922 (2.65), 8.625 (5.57), 8.699 (6.02), 9.157 (3.44), 10.731 (3.01).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 14080-56-9, Thieno[2,3-d]pyrimidin-4-amine.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BAYER AKTIENGESELLSCHAFT; KLAR, Ulrich; BOHLMANN, Rolf; SCHAeCKE, Heike; SUeLZLE, Detlev; MENZ, Stephan; PANKNIN, Olaf; (249 pag.)WO2018/134148; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 14080-56-9, Thieno[2,3-d]pyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 14080-56-9, blongs to pyrimidines compound. Quality Control of Thieno[2,3-d]pyrimidin-4-amine

To a solution of 100 mg (253 pmol) 6-bromo-4-hydroxy-8-methyl-4-(trifluoromethyl)-2H-spiro[cyclohexane-1 ,3-imidazo[1 ,5-a]pyridine]-1 ,5-dione (prepared according to example127a) and 42 mg (278 pmol) thieno[2,3-d]pyrimidin-4-amine (GAS-No.: 14080-56-9) in 8.2 mL 1 ,4-dioxane was added 247 mg cesium carbonate and the mixture was degassed and purged with argon several times. 15.7 mg 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene, 12.9 mg 2-(dicyclohexyl-phosphino)-2,4,6-triisopropylbiphenyl, 6.1 mg palladium(ll)acetateand 24.8 mg tris(dibenzylideneacetone)dipalladium(0) were added and the mixture was stirred at 1000 for 2 hours. After concentration t he residue was purified by flash chromatography (Biotage SNAP cartridge silica 25 g, methanol: dichloromethane) and crystallization from methanol to give 42 mg (32%) of the title compound. LC-MS: m/z = 466.2 [M÷H].1HNMR (400 MHz, DMSO-d6), 6 [ppm]= 1.43 (2H), 1.83 (2H), 1.96 (2H), 2.52 (3H*), 3.46(2H), 5.99 (1H), 7.82 (1H), 7.87 (1H), 8.65 (1H), 8.70 (1H), 9.07 (1H), 10.43 (1H);*: at least partially hidden by solvent or water signal

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,14080-56-9, its application will become more common.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BAYER AKTIENGESELLSCHAFT; KLAR, Ulrich; BOHLMANN, Rolf; SCHAeCKE, Heike; SUeLZLE, Detlev; MENZ, Stephan; PANKNIN, Olaf; (249 pag.)WO2018/134148; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia