Category: 14160-85-1

Product class 12: pyrimidines was written by von Angerer, S.. And the article was included in Science of Synthesis in 2004.COA of Formula: C6H6N2O3 The following contents are mentioned in the article:

A review. Methods for preparing pyrimidines are reviewed including cyclization, ring transformation, aromatization and substituent modification. This study involved multiple reactions and reactants, such as 4,6-Dihydroxy-2-methylpyrimidine-5-carbaldehyde (cas: 14160-85-1COA of Formula: C6H6N2O3).

4,6-Dihydroxy-2-methylpyrimidine-5-carbaldehyde (cas: 14160-85-1) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.COA of Formula: C6H6N2O3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The Vilsmeier reaction of fully conjugated carbocycles and heterocycles was written by Jones, Gurnos;Stanforth, Stephen P.. And the article was included in Organic Reactions (Hoboken, NJ, United States) in 1997.Safety of 4,6-Dihydroxy-2-methylpyrimidine-5-carbaldehyde The following contents are mentioned in the article:

A review of the article The Vilsmeier reaction of fully conjugated carbocycles and heterocycles. This study involved multiple reactions and reactants, such as 4,6-Dihydroxy-2-methylpyrimidine-5-carbaldehyde (cas: 14160-85-1Safety of 4,6-Dihydroxy-2-methylpyrimidine-5-carbaldehyde).

4,6-Dihydroxy-2-methylpyrimidine-5-carbaldehyde (cas: 14160-85-1) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Safety of 4,6-Dihydroxy-2-methylpyrimidine-5-carbaldehyde

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The Reimer-Tiemann reaction was written by Wynberg, Hans;Meijer, Egbert W.. And the article was included in Organic Reactions (Hoboken, NJ, United States) in 1982.Related Products of 14160-85-1 The following contents are mentioned in the article:

A review of the article The Reimer-Tiemann reaction. This study involved multiple reactions and reactants, such as 4,6-Dihydroxy-2-methylpyrimidine-5-carbaldehyde (cas: 14160-85-1Related Products of 14160-85-1).

4,6-Dihydroxy-2-methylpyrimidine-5-carbaldehyde (cas: 14160-85-1) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Related Products of 14160-85-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Syntheses in the heterocyclic series. XVII. Syntheses and reactions of pyrimidine-5-carboxaldehydes was written by Bredereck, Hellmut;Simchen, Gerhard;Wagner, Hans;Santos, Antonio A.. And the article was included in Justus Liebigs Annalen der Chemie in 1972.Application of 14160-85-1 The following contents are mentioned in the article:

Formylation of the pyrimidines I (R = H, Me, or Ph; X = H) with MeN:+CHCl Cl- gave I [X = CH:N+Me2 Cl- (II)]. Reaction of II with H2O, PhNHNH2, MeNH2, POCl3, or NaCH(CO2Et)2 gave the aldehydes I (X = CHO), the hydrazones I (X = CH:NNHPh), the imines I (X = CH:NMe), the dichloro derivatives III, or the pyrones IV, resp. Hydrogenation of III (R = H) over Pd-C and MgO gave 84% pyrimidine-5-carboxaldehyde, which can undergo most of the aldehyde reactions under mild conditions. This study involved multiple reactions and reactants, such as 4,6-Dihydroxy-2-methylpyrimidine-5-carbaldehyde (cas: 14160-85-1Application of 14160-85-1).

4,6-Dihydroxy-2-methylpyrimidine-5-carbaldehyde (cas: 14160-85-1) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Application of 14160-85-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis in the heterocyclic series. IX. Syntheses and reactions of 4,6-disubstituted pyrimidine-5-aldehydes was written by Bredereck, Hellmut;Simchen, Gerhard;Santos, Antonio A.. And the article was included in Chemische Berichte in 1967.HPLC of Formula: 14160-85-1 The following contents are mentioned in the article:

cf. CA 66, 94992n. In the reactions of dihydroxypyrimidines with Vilsmeier reagents, uracil gave (Me2N+:CHNHCOCH:CHOH)Cl-, and 4-hydroxy-6-oxodihydropyrimidines (I, R = H, Me, or Ph) were formylated at their 5-position to give 4-hydroxy-6-oxo-5-dimethylaminomethylene-5,6-dihydropyrimidine-HCl derivatives (II) which were converted, by POCl3/PhNMe2, into 4,6-dichloro-5-formylpyrimidine derivatives (III). III were converted, by nucleophilic agents (RR’NH or MeNH2), into 4-amino-6-chloro-5-formylpyrimidine derivatives (IV, R = H, Me, or Ph, R’ = H or Me) or 4,6-bis(methylamino)-5-methylaminomethylenepyrimidine. II were treated with Et malonate to give 7H-pyrano[2,3-d]pyrimidine derivatives (V). This study involved multiple reactions and reactants, such as 4,6-Dihydroxy-2-methylpyrimidine-5-carbaldehyde (cas: 14160-85-1HPLC of Formula: 14160-85-1).

4,6-Dihydroxy-2-methylpyrimidine-5-carbaldehyde (cas: 14160-85-1) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.HPLC of Formula: 14160-85-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis of pyrimidine-5-carboxaldehydes by the Reimer-Tiemann reaction was written by Wiley, Richard H.;Yamamoto, Yuzuru. And the article was included in Journal of Organic Chemistry in 1960.Application of 14160-85-1 The following contents are mentioned in the article:

Substituted pyrimidines, N:CR.N:CR¹.CX:CR² (I, X = H, R = OH. Me, OH, SH, SMe, OH, Me, H, H, OH, R¹ = OH, OH, OH, OH, OH, Me, OH, OH, OH, OH, R² = H, OH, Me, Me, Me, Me, Me, Me, H, OH) (II-XI) were submitted to the Reimer-Tiemann reaction by treatment 1 h. in dilute alc. with KOH and CHCl₃ at 80° and neutralization of the precipitate K salts with AcOH to give the corresponding 5-carboxaldehydes I (X = CHO) (XII). The monohydroxylated pyrimidines V, VI, VII, and VIII did not precipitate the K salt and were isolated through a suitable derivative Data were tabulated for the isolated XII [pyrimidine, % yield of XII, and m.p. (solvent) given)]: XI, 42, 330° (H₂O); II, 18, 304° (MeOH, H₂O); III, 29, 300° (AcOH); IV, 14, -; V, 17, 300° (H₂O); VI, 14, 300° (dilute alc.); VII, 26, -; VIII, 13, -. IX gave only 1.5% non-characterized derivative and no aldehyde or derivative was obtained from X. The data were consistent with the established difference in reactivity between IX and VIII, the less reactive nature of the pyrimidine nucleus than that of benzene, and the mechanism of the Reimer-Tiemann reaction. Various derivatives of XII were prepared and m.p. data listed [aldehyde, m.p. (solvent) of phenylhydrazone, dinitrophenylhydrazone, dimethylhydrazone, bis(2-hydroxyethyl)hydrazone, oxime, and semicarbazone of the corresponding XII given]: XI, 271-3° (AcOH), 301-2° (HCONMe₂-alc.), 283-4° (MeOH), -, 250° (H₂O),-; II, 298-300° (HCONMe₂), 270-2° (MeOH), -, above 330° (MeOH), 260° (HCONMe₂), 240° (reprecipitated from alk. solution); III, 240° (reprecipitated), above 330° (HCONMe₂-H₂O), 200° (EtOAc), -, -, 205° (reprecipitated); IV, -, -, 258-9° (MeOH), 320° (MeOH), 260° (MeOH),-; V, 276-7° (MeOH), -, 232-3° (MeOH), -, -, -; VI, 250-1° (MeOH), 283-4° (HCONMe₂), 168-70° (MeOH), -, 228-9° (MeOH), 263° (reprecipitated); VII, 229-31° (MeOH), -, -, -, -, -; VIII, 277-9° (MeOH), 305° (HCONMe₂), 192-3° (MeOH), -, 238-40° (MeOH), 265-6° (reprecipitated from alk. solution). CHCl₃ (24 mL.) and 56 g. KOH in 60 mL. H₂O added in 20 min. with stirring to 22.4 g. II and 11.2 g. KOH in 180 mL. 5:4 H₂O-alc. at 80°, the mixture refluxed 1 h., the cooled mixture filtered from KCl, kept 10 h. at 20°, the precipitated K salt suspended in H₂O, and neutralized with AcOH gave 8.6% XII (R = R¹ = OH, R² = H). The filtrate with PhNHNH₂ gave 9.4% phenylhydrazone. XII (R = R¹ = OH, R² = Me) oxime (XIII) (0.5 g.) and 10 mL. Ac₂O refluxed 30 min. and the hot filtered solution cooled to 20° gave 0.15 g. I (R = R¹ = OH, R² = Me, X = CN), m. above 330°, λ 273 mμ, also obtained (56%) by refluxing 0.5 g. XIII with 4.5 mL. POCl₃, pouring the mixture onto ice, and recrystallizing from alc. XIII (0.7 g.) in 6 mL. POCl₃ treated slowly with cooling with 3 mL. PhNMe₂, the mixture refluxed 30 min., cooled, poured onto ice, extracted with Et₂O, and the product recrystallized from ligroine (b. 60-80°) yielded 57% I (R = R¹ = OH, R² = Me, X = CN), m. 93-4°, converted by recrystallization from EtOH to I [R = Cl(EtO), R¹ = EtO(Cl), R² = Me, X = CN], m. 134-6°. The ease with which XIII was dehydrated suggested that the HO group and H atom were in the trans configuration. This study involved multiple reactions and reactants, such as 4,6-Dihydroxy-2-methylpyrimidine-5-carbaldehyde (cas: 14160-85-1Application of 14160-85-1).

4,6-Dihydroxy-2-methylpyrimidine-5-carbaldehyde (cas: 14160-85-1) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Application of 14160-85-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia