Category: 1421433-87-5

Adding a certain compound to certain chemical reactions, such as: 1421433-87-5, 7-Chloro-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 7-Chloro-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one, blongs to pyrimidines compound. Quality Control of 7-Chloro-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

To the above mixture was added Boc2O (1.999 g, 11.65 mmol) and DMAP (0.142 g, 1.17 mmol). The reaction mixture was stirred at rt for 3 h, diluted with brine (30 mL) and extracted with ethyl acetate (20 mL*2). Combined organic parts were washed with brine (20 mL*2), dried over anhydrous Na2SO4 and concentrated. Purification via column on silica gel (eluent: ethylacetate) afforded the title product (1.5 g) as a white solid. LC-MS (ESI): m/z 272 [M+H]+; 1.24 min (ret time)

The synthetic route of 1421433-87-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GlaxoSmithKline Intellectual Property Development Limited; WAN, Zehong; Sang, Yingxia; Zhang, Qing; US2014/213599; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1421433-87-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1421433-87-5 as follows.

D25 7-chloro-1-isopropyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one A mixture of 7-chloro-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (700 mg, 4.08 mol), 2-iodopropane (1.04 g, 6.12 mmol) and Cs2CO3 (2.66 g, 8.16 mmol) in acetonitrile (15 mL) was refluxed for 3 h, filtered and concentrated to remove solvent to get crude product (700 mg) without further purification. LC-MS (ESI): m/z 214 [M+H]+; 0.93 min (ret time)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1421433-87-5, its application will become more common.

Reference:
Patent; Glaxo Group Limited; Wan, Zehong; Long, Kai; Sang, Yingxia; Su, Xiaobo; US2014/179715; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia