Application of 1431412-19-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1431412-19-9, name is 4-Methoxyfuro[3,2-d]pyrimidine-6-carboxylic acid. A new synthetic method of this compound is introduced below.
To a solution of the above 4-methoxyfuro[3,2-d]pyrimidine-6-carboxylic acid (83; 3 g, 15 mmol), benzyltriethyl ammonium chloride (7 g, 31 mmol) and dimethyl aniline (3 mL, 24 mmol) in acetonitrile (70 mL) at 60 C was added phosphorous oxychioride (10 mL). The mixture was stirred at 60 C for 4 h. The reaction mixture was concentrated in vacuo, the residue was dissolved in THF, and ammonium hydroxide solution was added until pH = 9. The solid was filtered and dried to obtain 4-chlorofuro[3,2-d]pyrimidine-6-carboxamide(Compound 84; 1.0 g, 33%). MS (ESI) calcd for C7H4C1N302: 197.00; found: 198 [M+H].
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1431412-19-9, 4-Methoxyfuro[3,2-d]pyrimidine-6-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; GLAXOSMITHKLINE LLC; BLUM, Charles, A.; DISCH, Jeremy, S.; EVINDAR, Ghotas; PERNI, Robert, B.; WO2014/138562; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia