1436686-17-7 | Pyrimidines

Application of 1436686-17-7

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1436686-17-7, Ethyl 5-bromopyrazolo[1,5-a]pyrimidine-3-carboxylate.

Electric Literature of 1436686-17-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1436686-17-7, name is Ethyl 5-bromopyrazolo[1,5-a]pyrimidine-3-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.

Bromopyrazolo [1,5-a] pyrimidine-3-carboxylate (500 mg, 1.7 mmol)In dioxane (15 ml)Potassium acetate (330 mg, 3.4 mmol) was added,Cyclohexylboronic acid (174 mg, 2.1 mmol),After nitrogen protection PdCl2 (dppf) .DCM (138 mg, 0.17 mmol) was added,The reaction was warmed to 90 C for 2.5 hours.After the reaction was completed, the residue was concentrated under reduced pressure, the resulting residue was diluted with water and extracted with dichloromethane (20×3). The combined organic phases were washed with saturated sodium chloride solution, dried over anhydrous sodium sulphate and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (DCM / EA (v / v) = 6/1) to give the title compound as Brown solid (220 mg, 57%).

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; (88 pag.)CN104650092; (2017); B;,
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Share a compound : 1436686-17-7

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1436686-17-7, its application will become more common.

Related Products of 1436686-17-7 ,Some common heterocyclic compound, 1436686-17-7, molecular formula is C9H8BrN3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 0.28 g (1 .14 mmol) of compound 1-2 in 1.5 mL of EtOH were added 0.31 g (1 .14 mmol) of compound 2-2 and 0.026 g (0.23 mmol) of TFA at room temperature. The mixture in a sealed tube was stirred at 90 C overnight under N2atmosphere and cooled to rt. It was diluted with 10 mL of ethyl acetate and 50 mL of water, and extracted with three 50 mL portions of ethyl acetate. The combined organic extracts were washed with brine, and dried over anhydrous Na2S04. After filtration, the filtrate was concentrated to afford a residue, which was purified by chromatography on silica gel column eluted with 50% of ethyl acetate in petroleum ether to afford compound 1-3. LC-MS: m/e = 435 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1436686-17-7, its application will become more common.

Reference:
Patent; ANGEX PHARMACEUTICAL, INC.; WU, Wen-Lian; YANG, Zhiqiang; LEE, Francis; TAN, John Qiang; (112 pag.)WO2019/94143; (2019); A1;,
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Sources of common compounds: Ethyl 5-bromopyrazolo[1,5-a]pyrimidine-3-carboxylate

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1436686-17-7, Ethyl 5-bromopyrazolo[1,5-a]pyrimidine-3-carboxylate.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1436686-17-7, name is Ethyl 5-bromopyrazolo[1,5-a]pyrimidine-3-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: Ethyl 5-bromopyrazolo[1,5-a]pyrimidine-3-carboxylate

General procedure: To a solution of 2.8 g (1 1 mmol) compound 1 -11 hydrogen chloride salt and 2.9 g (1 1 mmol) of compound 2 in 50 imL of EtOH was added 4.35 g (43.1 mmol) of EtaN. The mixture was stirred at 90 C for 2 h under nitrogen atmosphere and cooled to rt. It was concentrated under reduced pressure to afford a residue, which was purified by chromatography on silica gel column eluting with 20 % of ethyl acetate in petroleum ether to afford compound 1 -12. LC- MS: m/e = 416 [M+H]+.

A new synthetic route of 1436686-17-7

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1436686-17-7, name is Ethyl 5-bromopyrazolo[1,5-a]pyrimidine-3-carboxylate. A new synthetic method of this compound is introduced below., HPLC of Formula: C9H8BrN3O2

To a solution of cyclopropylboronic acid (174mg, 2.1mmol), KOAc (330mg, 3.4mmol), ethyl 5-bromopyrazolo[l,5-a]pyrimidine-3-carboxylate (500mg, 1.7mmol) in dioxane (15ml) was added PdCl2(dppf).DCM (138mg, 0.17mmol). The reaction mixture was stirred at 90 C for 2.5 h under a nitrogen atmosphere and then concentrated in vacuo. The residue was diluted with water and then extracted with DCM (20 x 3). The combined organic layers were washed with brine and dried over anhydrous Na2S04, filtered and concentrated in vacuo. The residue was purified by a silica gel column chromatography (DCM/EA (v/v) = 6/1) to give the title compound as a brown solid (220 mg, 57%). H NMR (300 MHz, CDC1 ): delta (ppm) 8.51 (d, J = 7.2 Hz, 1H), 8.47 (s, 1H), 6.78 (d, J = 7.2 Hz, 1H), 4.39 (q, J= 7.1 Hz, 2H), 2.25-2.16 (m, 1H), 1.41 (t, J= 7.1 Hz, 3H), 1.33-1.25 (m, 2H), 1.25- 1.14 (m, 2H).

Reference:
Patent; CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.; XI, Ning; LI, Minxiong; LI, Xiaobo; WO2015/73267; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
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