Category: 1450-85-7

Application of 1450-85-7 ,Some common heterocyclic compound, 1450-85-7, molecular formula is C4H4N2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Potassium tetrachloridopalladate(II) was prepared as described previously [11]. The complexes were prepared by adding 2 equivalents of potassium cyanide in 10 ml water to a solution of K2[PdCl2](0.326 g) in 15 ml of water followed by the addition of 2 equivalents of thioamides in 15 ml methanol after 15 min stirring. On addition of KCN a light yellow turbid solution was obtained, which turned to brown or red clear solution on addition of thiones (Caution: Potassium cyanide is extremely dangerous and must be handled with care). After stirring the solutions to 1 h, their colors changed to yellow or orange red. The solutions were filtrated and were kept at room temperature for three to five days. The solid products obtained were washed with methanol and air dried. The experimental yield of the products was around 60-70%. The elemental analyses and melting points (m.p) of the complexes are given in Table 1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1450-85-7, its application will become more common.

Reference:
Article; Ahmad, Saeed; Nadeem, Shafqat; Anwar, Aneela; Hameed, Abdul; Tirmizi, Syed Ahmed; Zierkiewicz, Wiktor; Abbas, Azhar; Isab, Anvarhusein A.; Alotaibi, Mshari A.; Journal of Molecular Structure; vol. 1141; (2017); p. 204 – 212;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1450-85-7, name is 2-Mercaptopyrimidine, molecular formula is C4H4N2S, molecular weight is 112.15, as common compound, the synthetic route is as follows.Computed Properties of C4H4N2S

General procedure: To an orange suspension of [Pd2(p-mazb)2Cl2] (0.025 g, 0.035 mmol) in dichloro-methane (5mL), pyridine-2-thione (0.008 g, 0.072 mmol) was added in presence of Et3N base (0.5 mL). The color of the reaction mixture became dark reddish brown and was stirred for 5-6 h. The solution was filtered off and added toluene (1 mL) and left to evaporate slowly. The dark reddish brown crystalline compound was obtained along with the formation of Et3NH+Cl- after a period of 4-5 days. Crystalline compound formed was recrystallized from dichloromethane and methanol. The dark reddish brown crystals were obtained after a period of 4-5 days. (Yield 0.021 g, 68%). .

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1450-85-7, 2-Mercaptopyrimidine, and friends who are interested can also refer to it.

Reference:
Article; Lobana, Tarlok S.; Sandhu, Amanpreet K.; Kaur, Amanpreet; Jasinski, Jerry P.; Journal of Organometallic Chemistry; vol. 751; (2014); p. 519 – 524;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia