Category: 1450-86-8

Adding a certain compound to certain chemical reactions, such as: 1450-86-8, Pyrimidine-4(3H)-thione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of Pyrimidine-4(3H)-thione, blongs to pyrimidines compound. Safety of Pyrimidine-4(3H)-thione

General procedure: To a solution of compound 1 (240 mg, 0.39mmol) in tetrahydrofuran (THF; 5ml) at 0 C were added triphenylphosphine (150 mg, 0.57 mmol), diethylazodicarboxylate (0.10ml, 0.55mmol) and benzo[d]oxazole-2-thiol (85 mg, 0.56ml) and stirred at 0 C for 1 h. The mixture was stirred at RT for 16 h. The mixture was diluted with 2N HCl (1ml)-MeOH (1ml) and then stirred at RT for 30 min and concentrated under reduced pressure. The resulting residue was dissolved by water and washed with diethyl ether. The mixture was added to NaHCO3 (150 mg), then extracted with ethyl acetate, washed with water, dried over MgSO4 and concentrated under reduced pressure. The resulting residue was purified by preparative TLC (CHCl3/CH3OH/28 % aq NH4OH=20/1/0.1) toobtain the title compound as a colorless solid (147.6mg, 71%).

The synthetic route of 1450-86-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wakiyama, Yoshinari; Kumura, Ko; Umemura, Eijiro; Ueda, Kazutaka; Masaki, Satomi; Kumura, Megumi; Fushimi, Hideki; Ajito, Keiichi; Journal of Antibiotics; vol. 69; 5; (2016); p. 368 – 380;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1450-86-8, name is Pyrimidine-4(3H)-thione, molecular formula is C4H4N2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of Pyrimidine-4(3H)-thione

EXAMPLE 1 4-(N-oxidopyridyl-3-methyl)thiopyrimidine 11.2 g (0.1 moles) 4-mercaptopyrimidine is dissolved in 100 ml ethanol containing 10.8 g sodium methoxide. 18 g (0.1 moles) 3-chloromethylpyridine-N-oxide hydrochloride is added; the mixture is heated under reflux for about one hours. The solution is cooled to ambient temperature, the sodium chloride filtered off, and the filtrate evaporated under vacuum to eliminate the solvent. The residue is crystallized from ethyl acetate to give 15.35 g of product (M.P.=105-108 C.; yield=70%).

With the rapid development of chemical substances, we look forward to future research findings about 1450-86-8.

Reference:
Patent; Poli Industria Chimica S.p.A.; US4224327; (1980); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia