Adding a certain compound to certain chemical reactions, such as: 145783-15-9, 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 145783-15-9, blongs to pyrimidines compound. Quality Control of 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine
ake a 500ml three-necked flask,Equipped with a condensing return tube and nitrogen ball protection.Add 2-[[(3AR,4S,6R,6AS)-6-aminotetrahydro-2,2-dimethyl-4H-cyclopenten-1,3-dioxolan-4-yl ]oxy]ethanol (88.7 g, 408.3 mmol, 1.0 eq), 4,6-dichloro-2-(propylthio)-5-aminopyrimidine (98.0 g, 408.3 mmol, 1.0 eq), N,N- Diisopropylethylamine (79.1 g, 612.5 mmol, 1.5 eq),Stir at 120-125 C for 10 hours (HPLC detection,The peak area percentage was 4,6-dichloro-2-(propylthio)-5-aminopyrimidine <1.0%), the heating was stopped and the temperature was lowered to <60 C, and ethyl acetate and water were added for washing and extraction. Concentrated to 200 ml of ethyl acetate under reduced pressure and recrystallized from petroleum ether.Made a white solid 160g,The yield is 93.5%.HPLC peak area percentage SM-C ? 98.5%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,145783-15-9, its application will become more common.
Reference:
Patent; Huaren Pharmaceutical Co., Ltd.; Feng Xinguang; Li Xuechao; Li Wei; (5 pag.)CN105198864; (2018); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia