Category: 145783-15-9

Adding a certain compound to certain chemical reactions, such as: 145783-15-9, 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine, blongs to pyrimidines compound. name: 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine

3) Operation process(1) Add 18L of ethylene glycol and 9.335kg of SM1 to the 100L reactor.12kg SM2 and 16.529kg triethylamine,Stir and mix;(2) heating the reaction solution to 90 ~ 100 C, the reaction liquid solid dissolved, the color is a yellow clear solution; maintaining this temperature for 8 to 10 hours;(3) TLC detection, the developing agent is ethyl acetate: methanol = 1:1, the color developing agent is ninhydrin ethanol solution, and the color is baked at 150 C;Lower the reaction solution to below 50 C,The reaction solution is a dark brown clear solution;The reaction solution was poured into a 200 L reaction vessel containing 50 L of ethyl acetate and 50 L of water under stirring at room temperature;The 100 L reaction kettle was rinsed with 10 L of ethyl acetate and 10 L of purified water.The eluent was poured into a 200 L reaction kettle; stirred at room temperature for 30 minutes; the stirring was stopped, and the layer was allowed to stand.Divide the lower aqueous phase;(4) Add 60 L of purified water to the upper organic phase, stir at room temperature for 30 minutes; stop stirring, let stand for stratification, and separate the lower layer.water box;(5) Transfer the upper organic phase to a 500L reactor and heat to 60-70 C with stirring; in addition, 180 L of isooctane pre-Heat to 60 ~ 70 C, added to the reaction flask;(8) After adding, slowly cool down to room temperature with stirring and firstly cool to 35-45 C (solid precipitation temperature about 30-35 C).Slowly cool down to 20 ~ 30 C; keep stirring at 20 ~ 30 C for 1 hour, and then slowly reduce the temperature to 0 ~ 10 C;(8) stirring at 0 to 10 C for 2 hours;(9) Centrifugal filtration, the reaction kettle and filter cake are mixed with 12 L of ethyl acetate pre-cooled to 0-10 C and 36 L of isooctane.Rinsing(10) The filter cake is dried under vacuum at 45-55 C for 12 to 16 hours to obtain a white powder of Im-1, weighing 11 kg, yield80%.

The synthetic route of 145783-15-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hebei Kaiwei Pharmaceutical Co., Ltd.; Pang Yuning; (23 pag.)CN108276417; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 145783-15-9, name is 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine. A new synthetic method of this compound is introduced below., Safety of 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine

4,6-Dichloro-2-(propylthio)pyrimidin-5-amine (0.5 g, 2.1 mmol) was dissolved in methanol (2 mL) and supplemented with te/t-butylamine (460.0 mg, 6.3 mmol). The reaction mixture was introduced in a sealed vessel and heated at 100C for 24 h. After concentration of the reaction mixture to dryness under vacuum, the residue was purified by silica gel column chromatography. Yield: 88%. Melting point: 88-89C. *H NMR (DMSO -d6) d 0.95 (t, J=7.3 Hz, 3H, SCH2CH2C/ ,), 1.43 (s, 9H, NHC(C/ ,)3), 1.62 (h, J=7.3 Hz, 2H, SCH2CH2CH3), 2.95 (t, J=7.3 Hz, 2H, SCH2CH2CH3), 4.91 (bs, 2H, NH2), 6.19 (s, 1H, NHC(CH3)3). 13C NMR (DMSO -d6) d 13.3 (SCH2CH2CH3), 22.9 (SCH2CH2CH3), 28.5 (NHC(CH3)3), 31.9(SCH2CH2CH3), 51.9 (NHC(CH3)3), 120.3 (C-5), 137.6 (C-6), 152.1 (C-4), 154.5 (C-2).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 145783-15-9, 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine.

Reference:
Patent; UNIVERSITE DE LIEGE; LANCELLOTTI, Patrizio; OURY, Cecile; PIROTTE, Bernard; (140 pag.)WO2019/158655; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 145783-15-9, 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 145783-15-9, blongs to pyrimidines compound. category: pyrimidines

(1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine (R)-mandelate (Compound II, 3.31 g, 10 mmol) and4,6-Dichloro-2-(propylthio)-5-aminopyrimidine (Compound I, 2 g, 13 mmol) was placed in a 50 mL three-necked flask, and ethylene glycol (10 mL) and triethylamine (4.24 g, 42 mmol) were added. ). The reaction mixture was heated to 100 C and stirred for 7 hours. Turn off the heat and naturally cool to 40 C. Isopropyl acetate (10 mL) and water (10 mL) were added and stirred for 1 hour. Stirring was stopped, cooled to room temperature, and allowed to stand for liquid separation. The organic phase was separated, washed with water (10 mL) and dried The mixture was filtered with suction, and the residue was purified by silica gel column chromatography (200-300 mesh chromatography, eluent 0-50% ethyl acetate / petroleum ether) to give compound III (2.6 g, 68 %), light gray solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,145783-15-9, its application will become more common.

Reference:
Patent; Yangzijiang Pharmaceutical Group Co., Ltd.; Miao Shifeng; Xu Haoyu; Cai Wei; Zhang Haibo; Lv Huimin; Sun Chunyan; Mu Cong; Wang Deguo; Liu Jinglong; Liu Jing; Hu Tao; (11 pag.)CN109553622; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.145783-15-9, name is 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine, molecular formula is C7H9Cl2N3S, molecular weight is 238.14, as common compound, the synthetic route is as follows.Computed Properties of C7H9Cl2N3S

Compound (1-a?) (524 mg, 2.2 mmol), compound (2?) (703 mmg, 2.4 mmol) and NaHCO3 (203 mg, 2.4 mmol) were added to DMF (25 ml). Under the nitrogen atmosphere, the mixture was stirred for 12-15 h at 90-95 C. The reaction was monitored by TLC. After completion, H2O (110 ml) and CH2Cl2 (110 ml) were added to the mixture and then stirring for 30 min. Then the aqueous and organic layers were separated. The CH2Cl2 was washed to neutral with H2O (25 ml*3). The organic layer was dried with anhydrous sodium sulfate, and then filtered. The CH2Cl2 layer was removed by distillation at reduced pressure to obtain crude product (compound (1-c?). The crude product was crystallized from a mixture of dichloromethane and petroleum ether to obtain a white solid (933 mg, yield 79.0%). HPLC purification is above 98%. 1HNMR (400 MHz, CDCl3) delta: 7.31-7.34 (m, 5H), 6.79 (b, 2H), 5.36 (s, 2H), 4.60-4.72 (m, 2H), 4.51-4.53 (m, 1H), 3.94 (d, J=7.6 Hz, 1H), 3.64-3.80 (m, 3H), 3.63-3.64 (m, 1H), 3.02-3.22 (m, 2H), 2.31-2.33 (m, 1H), 1.93-1.94 (m, 1H), 1.72-1.82 (m, 2H), 1.08 (t, J=7.6 Hz, 3H). MS (m/z): [M+H]+=495.15.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,145783-15-9, 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine, and friends who are interested can also refer to it.

Reference:
Patent; BRIGHTGENE BIO-MEDICAL TECHNOLOGY (SUZHOU) CO., LTD; YUAN, Jiandong; JIANG, Qiao; LI, Xiang; US2015/322071; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 145783-15-9, name is 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine, the common compound, a new synthetic route is introduced below. Recommanded Product: 145783-15-9

Vc (63.29 g, 0.21 mol) was added to 500 mL of absolute ethanol.VI (50.00 g, 0.21 mol) and triethylamine (63.63 g, 0.63 mol) were added.The reaction is sealed, protected by nitrogen, and heated to 100-130 C.The reaction is carried out for 25 to 30 hours, the temperature is lowered, and the solvent is distilled off under reduced pressure.Add 300 mL of ethyl acetate and 300 mL of water.The pH of the solution was adjusted to 5 with 3M hydrochloric acid to separate the organic phase.It was dried over anhydrous sodium sulfate for 2 hours, and concentrated under reduced pressure to half.Add 400 mL of isooctane, stir and crystallize at 15 C for 10 hours, and filter.Collect solids and dry to give compound IVc92.96 g, yield 88%.

The synthetic route of 145783-15-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Tianfang Pharmaceutical Co., Ltd.; Fan Zhen; Ma Junxia; Zhou Xinjian; Wang Junchen; Ren Zhen; Ma Qi; Wang Hui; Wu Xiangyong; Zhang Xiangfei; Zhao Zhen; Ma Zhenzhen; (12 pag.)CN108690026; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 145783-15-9 ,Some common heterocyclic compound, 145783-15-9, molecular formula is C7H9Cl2N3S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

23.80 g of 4,6-dichloro-2-propylthio-5-aminopyrimidine was added to the reaction flask.51.7 g of N,N-diisopropylethylenediamine, 9.36 g of cyclopentylamine and 200 ml of DMF,Stir and heat to 90 C, TLC control reaction is complete, cooled to room temperature,The reaction solution was poured into 100 ml of cold water and extracted with ethyl acetate (30 ml ¡Á 3).The organic phase was dried over anhydrous magnesiumYield 24.38 g of a nearly brown solid III-1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,145783-15-9, its application will become more common.

Reference:
Patent; Tianjin Pharmaceutical Institute Co., Ltd.; Liu Bingni; Liu Dengke; Zhi Shuang; Shang Qian; (19 pag.)CN109516990; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 145783-15-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 145783-15-9, name is 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine, molecular formula is C7H9Cl2N3S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Method B: Compound (IX) (150 g, 0.6 mole) (IX was purchased from Shanghai Haoyuan Chemexpress Co., Ltd.) was dissolved in 1.0 L N,N-dimethyl formamide (DMF). Pyridine (69.3 g, 1.0 mole) was added to the solution. The solution was cooled in ice water until the system internal temperature was below 10C. Pentafluorophenyl trifluoroacetate (184.5 g, 0.66 mole) was slowly added dropwise to the solution. After pentafluorophenyl trifluoroacetate was added completely, the solution was allowed to warm naturally to room temperature, and was stirred for 5 h. The reaction was monitored by HPLC. Afier the conversion of the raw material was complete, 2.0 L tap water was added to the reaction solution. The reaction solution was extracted twice with 1 .0 L methyl tertiary-butyl ether. The organic phase was washed with 0.5 L saturated salt water, then dried for not less than 3 h, filtered and concentrated to get 186.2 g compound (VIII) in 93% yield. The resulting product was directly used in the nextstep.

According to the analysis of related databases, 145783-15-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; JIANGSU HENGRUI MEDICINE CO., LTD.; SUNCADIA PHARMACEUTICALS CO., LTD.; SUN, Shaoguang; SONG, Defu; HE, Biao; LAI, Xiaobo; (22 pag.)US2016/52928; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia