Adding a certain compound to certain chemical reactions, such as: 147972-27-8, 4-Chloro-2-(trifluoromethyl)thieno[3,2-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C7H2ClF3N2S, blongs to pyrimidines compound. COA of Formula: C7H2ClF3N2S
phenyl 2-trifluoromethylthieno[3,2-d]pyrimidin-4-ylmethanone (Example 1) A suspension of 4-chloro-2-trifluoromethylthieno[3,2-d]pyrimidine (0.3 g, 1.26 mmol), benzaldehyde (0.28 g, 2.64 mmol) and N,N-dimethylimidazolium iodide (0.2 g, 0.89 mmol) in THF (8 ML) was treated with NaH (60% dispersion in oil, 0.112 g, 2.8 mmol), refluxed for 15 min, cooled to room temperature, treated with water (4 ML) and the organic phase separated.. The aqueous phase was extracted with CH2Cl2 (2*20 ML), the combined organic phase washed with brine (10 ML), dried (MgSO4), concentrated in vacuo and the resulting brown oil purified by chromatography [SiO2; heptane-EtOAc (3:1)] then recrystallized from heptane to give the title compound (280 mg, 43%) as yellow needles.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,147972-27-8, 4-Chloro-2-(trifluoromethyl)thieno[3,2-d]pyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Vernalis Research Limited; US6787541; (2004); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia