Category: 1480-66-6

Related Products of 1480-66-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1480-66-6, name is 6-Chloro-2-(trifluoromethyl)pyrimidin-4-amine, molecular formula is C5H3ClF3N3, molecular weight is 197.5456, as common compound, the synthetic route is as follows.

General procedure: To a solution of 6-chloro-2-methylpyrimidin-4-amine (1.0 equiv.) in THF (0.17M) was added BOC2O (1.1 equiv.) and DMAP (cat.). The reaction was allowed to stir overnight, then concentrated to a yellow crude, and filtered through a pad of SiO2 eluting with EtOAc and hexanes (1:1) to afford an off-white solid (78 %).

Statistics shows that 1480-66-6 is playing an increasingly important role. we look forward to future research findings about 6-Chloro-2-(trifluoromethyl)pyrimidin-4-amine.

Reference:
Article; Nishiguchi, Gisele A.; Burger, Matthew T.; Han, Wooseok; Lan, Jiong; Atallah, Gordana; Tamez, Victoriano; Lindvall, Mika; Bellamacina, Cornelia; Garcia, Pablo; Feucht, Paul; Zavorotinskaya, Tatiana; Dai, Yumin; Wong, Kent; Bioorganic and Medicinal Chemistry Letters; vol. 26; 9; (2016); p. 2328 – 2332;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1480-66-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1480-66-6, name is 6-Chloro-2-(trifluoromethyl)pyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.

Key Intermediate 5 (Int-5): (6-Chloro-2-trifluoromethyl-pyrimidin-4-yl)-[5-(3-ethoxy-benzenesulfonyl)-thiazol-2-yl]-amine; A mixture of 4-amino-6-chloro-2-trifluoromethyl-pyrimidine [(Inoue, S. et al, J. Org. Chem., 1961, 26, 4504) 185 mg, 0.94 mol] and NaH (60% dispersion in mineral oil, 40 mg, 1.0 mmol) in DMF (4.0 mL) was stirred, under Ar, at RT for 30 min. A solution of Intl-A (326 mg, 0.94 mmol) in DMF (2.0 mL) was added. The reaction mixture was stirred at RT for 30 min and was heated at 55 C. for 1 h. Additional NaH (60% dispersion in mineral oil, 20 mg, 0.05 mmol) was added, and the reaction mixture was heated at 55 C. overnight. Additional NaH (60% dispersion in mineral oil, 20 mg, 0.05 mmol) was added, and the reaction mixture was heated at 55 C. for 1 h. The reaction mixture was cooled to RT and partitioned between EtOAc (ca. 100 mL) and water (ca. 25 mL). The layers were separated and the organic phase was washed with saturated aqueous NaCl (1×100 mL), dried (Na2SO4), and concentrated under reduced pressure to give an oil. This oil was purified by flash chromatography, elution with 25-75% EtOAc in hexanes, to give Int-5 (182 mg, 42%) as a foam. LCMS (m/z): 465, 467 (M+H)+

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1480-66-6, 6-Chloro-2-(trifluoromethyl)pyrimidin-4-amine.

Reference:
Patent; ICAGEN, INC.; US2007/197523; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 1480-66-6, 6-Chloro-2-(trifluoromethyl)pyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 1480-66-6, blongs to pyrimidines compound. Product Details of 1480-66-6

6-Chloro-2-(trifluoromethyl)pyrimidin-4-amine (50 mg, 0.221 mmol) and potassium thioacetate (37.9 mg, 0.331 mmol) in Dioxane (3 ml) were heated in microwave (Temp. l00C, Hold time 10 min., Pressure 300, Power 150). After cooling, excess solvent was evaporated under reduced pressure. The reaction mixture was partitioned between ethyl acetate and water. The aqueous phase was extracted again with ethyl acetate. The organic solvent was then dried over MgS04 and evaporated under reduced pressure. The combined organic layers were dried over anhydrous MgS04 and evaporated under reduced pressure. The obtained residue was taken to the next step without further purification. LC/MS: m/z 196 (M+H)+.

The synthetic route of 1480-66-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; HELMHOLTZ-ZENTRUM FUeR INFEKTIONSFORSCHUNG GMBH; AHMED, Ahmed S. A.; EMPTING, Martin; HAMED, Mostafa; HARTMANN, Rolf W.; HAUPENTHAL, Joerg; HASTERKAMP, Thomas; KAMAL, Ahmed A. M.; MAURER, Christine K.; ROeHRIG, Teresa; SCHUeTZ, Christian; YAHIAOUI, Samir; ZENDER, Michael; (128 pag.)WO2020/7938; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1480-66-6 ,Some common heterocyclic compound, 1480-66-6, molecular formula is C5H3ClF3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Key Intermediate 5 fljit-5″): (6-Chloro-24rifluoromethyl-pyrimidin-4-ylV[“5-(3-ethoxy- benzenesulfonyl)-thiazol-2-vn-amine[0114] A mixture of 4-amino-6-chloro-2-trifluoromethyl-pyrimidine [(Inoue, S. et al, J.Org. Chem., 1961, 26, 4504) 185 mg, 0.94 mol] and NaH (60% dispersion in mineral oil, 40 mg, 1.0 mmol) in DMF (4.0 mL) was stirred, under Ar, at RT for 30 min. A solution of Intl -A (326 mg, 0.94 mmol) in DMF (2.0 mL) was added. The reaction mixture was stirred at RT for 30 min and was heated at 55 0C for Ih. Additional NaH (60% dispersion in mineral oil, 20 mg, 0.05 mmol) was added, and the reaction mixture was heated at 55 0C overnight. Additional NaH (60% dispersion in mineral oil, 20 mg, 0.05 mmol) was added, and the reaction mixture was heated at 55 0C for 1 h. The reaction mixture was cooled to RT and partitioned between EtOAc (ca. 100 mL) and water (ca. 25 mL). The layers were separated and the organic phase was washed with saturated aqueous NaCl (I x 100 mL), dried (Na2SO4), and concentrated under reduced pressure to give an oil. This oil was purified by flash chromatography, elution with 25-75% EtOAc in hexanes, to give Int-5 (182 mg, 42%) as a foam. LCMS (m/z): 465, 467 (M+H)+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1480-66-6, 6-Chloro-2-(trifluoromethyl)pyrimidin-4-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ICAGEN, INC.; WO2007/75852; (2007); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia