Category: 1480-96-2

Application of 1480-96-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1480-96-2 as follows.

43b2-Methoxy-5-fluorouracil (43a, 1.04g, 7.21 mmol) and N,N-dimethylaniline (1.80 mL) were heated in POCI3 at 11O0C for 90 minutes. After cooling, the reaction was added carefully to ice. The product was extracted with diethylether. The ether layer was washed with sequentially with 2N HCI, water, and brine followed by drying (MgSO4). The ether was carefully removed under reduced pressure to give 43b as a volatile liquid (0.39g, 34%) which was used without further purification. Rf = 0.26 (10% EtOAc/hexane). 1H NMR (400MHz, DMSO-d6): delta 3.91 (s, 3H), 8.79 (s, 1 H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1480-96-2, its application will become more common.

Reference:
Patent; PFIZER INC.; WO2006/72831; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1480-96-2, Adding some certain compound to certain chemical reactions, such as: 1480-96-2, name is 5-Fluoro-2-methoxypyrimidin-4(3H)-one,molecular formula is C5H5FN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1480-96-2.

500 g of methanol was placed in a constant-temperature reaction bath, and hydrogen chloride gas was introduced until the methanol increased weight to 543 g-556 g to stop aeration. The prepared methanol solution of hydrogen chloride was placed in a refrigerator for use.In a dry and clean 500 mL four-neck flask, 250 g of hydrochloric acid in methanol was added, and 50 g of 2-methoxy-5-fluorouracil was stirred. When the temperature was raised to 28 C., incubation was started. After 5 h, samples were taken for HPLC detection. At 0.07%, the reaction was completed, the temperature was lowered to 15C, and the resulting solid was suction filtered.The refined 5-fluorouracil is refined and the mother liquor is concentrated after suction filtrationShrink the recovered methanol for use. The resulting 5-fluorouracil dry weight was 35.4 g, with a purity of 99.82% and a yield of 78.3%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1480-96-2, 5-Fluoro-2-methoxypyrimidin-4(3H)-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Jinghua Pharmaceutical Group Nantong Co., Ltd.; Yuan Yongjun; Shen Xiaojuan; Li Shufen; Chen Xuelian; Wu Yuxiang; (4 pag.)CN107963994; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia