149849-94-5 | Pyrimidines

29-Sep News New learning discoveries about 628692-15-9

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,149849-94-5, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 149849-94-5, Methyl 2-chloropyrimidine-4-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 149849-94-5, blongs to pyrimidines compound. Quality Control of Methyl 2-chloropyrimidine-4-carboxylate

To the solution of 1860 mg methyl 2-chloropyrimidine-4-carboxylate (10.78 mmol) in 11 mL THF 21.6 mL DIBAL-il (lM in THF, 21.6 mrnol) was added dropwise at -70C and it was stirred at this temperature for 16 h. 5 mL MeOH was added to it at -50C, then 5 mLwater was added to it at 0C. It was filtered through celite. The filtrate was concentrated under reduced pressure, aM then it was purified via flash chromatography using heptanc and EtOAe as eluents.?H NMR (200 MHz, CDCI3): 8.60 (d, 111), 7.38 (d, lH), 4.79 (s, 211).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,149849-94-5, its application will become more common.

Reference:
Patent; LES LABORATOIRES SERVIER; VERNALIS (R&D) LIMITED; KOTSCHY, Andras; SZLAVIK, Zoltan; CSEKEI, Marton; PACZAL, Attila; SZABO, Zoltan; SIPOS, Szabolcs; RADICS, Gabor; PROSZENYAK, Agnes; BALINT, Balazs; BRUNO, Alain; GENESTE, Olivier; DAVIDSON, James Edward Paul; MURRAY, James Brooke; CHEN, I-Jen; PERRON-SIERRA, Francoise; WO2015/97123; (2015); A1;,
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15-Sep News Some scientific research about 149849-94-5

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 149849-94-5, Methyl 2-chloropyrimidine-4-carboxylate, other downstream synthetic routes, hurry up and to see.

Related Products of 149849-94-5 ,Some common heterocyclic compound, 149849-94-5, molecular formula is C6H5ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of Example 28B (18 g) in 1,4-dioxane (150 mL) were added methyl 2- chloropyrimidine-4-carboxylate, potassium phosphate (21.5 g) and (l ,l’-bis(diphenylphosphino) ferrocene dichloro palladium(II) dichloromethane complex (2.54 g) at room temperature under nitrogen flow. The reaction mixture was stirred at 110 C for 3 hours under nitrogen atmosphere, cooled and filtered. The filtrate was concentrated and the residue was purified by flash column chromatography on silica gel (eluting with ethyl acetate: methanol = 10:1) to provide the title compound. ‘H NMR(400MHz, dimethylsulfoxide-de) delta ppm 9.25 (dd, 1H), 8.10 (dd, 1H), 7.62-7.41 (m, 1H), 6.67-6.52 (m, 2H), 3.95 (d, 3H), 3.42 (d, J=l .l Hz, 3H).

Reference:
Patent; ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG; BRAJE, Wilfried; DOHERTY, George; JANTOS, Katja; JI, Cheng; JUDD, Andrew; KUNZER, Aaron; MASTRACCHIO, Anthony; SONG, Xiaohong; SOUERS, Andrew; SULLIVAN, Gerard; TAO, Zhi-Fu; LAI, Chunqui; KLING, Andreas; POHLKI, Frauke; TESKE, Jessc; WENDT, Michael; BRADY, Patrick; WANG, Xilu; PENNING, Thomas; MICHAELIDES, Michael; (448 pag.)WO2019/35927; (2019); A1;,
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9 Sep 2021 News Share a compound : 149849-94-5

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 149849-94-5, Methyl 2-chloropyrimidine-4-carboxylate.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 149849-94-5, name is Methyl 2-chloropyrimidine-4-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of Methyl 2-chloropyrimidine-4-carboxylate

A solution of 5-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-4-(trifluoromethyl)-2-[[2-(trimethylsilyl)ethoxy]methyl]-2,3-dihydropyridazin-3-one (500 mg, 1.27 mmol, 1.00 equiv), (Pd(allyl)C)2 (47 mg, 0.10 equiv), Rockphos (60 mg, 0.10 equiv), Cs2CO3 (829 mg, 2.54 mmol, 2.00 equiv), methyl 2-chloropyrimidine-4-carboxylate (547 mg, 3.17 mmol, 2.50 equiv) in toluene (10 mL) under nitrogen atmosphere was stirred overnight at 85 C. The solvent was concentrated under vacuum and the residue was applied onto a silica gel column eluting with EtOAc/petroleum ether (3/7) to afford 425 mg (63%) of the title compound as a yellow solid. LCMS (ESI, m/z): 530.20 [M+H]+.

Reference:
Patent; Ribon Therapeutics Inc.; Vasbinder, Melissa Marie; Schenkel, Laurie B.; Swinger, Kerren Kalai; Kuntz, Kevin Wayne; (410 pag.)US2019/330194; (2019); A1;,
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Share a compound : 149849-94-5

According to the analysis of related databases, 149849-94-5, the application of this compound in the production field has become more and more popular.

Synthetic Route of 149849-94-5, Adding some certain compound to certain chemical reactions, such as: 149849-94-5, name is Methyl 2-chloropyrimidine-4-carboxylate,molecular formula is C6H5ClN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 149849-94-5.

A 100 mL three neck flask was charged with NaH (55%, 130 mg) and tetrahydrofuran (2 mL). At 5 C tetraethyleneglycol monomethylether (530 mg) dissolved in tetrahydrofuran (2 mL) was added dropwise and the mixture was stirred for 1 hour at 5 C. A solution of methyl 2-chloropyrimidine-4- carboxylate (390 mg) in tetrahydrofuran (4 mL) was added at 5 C and stirring was continued at ambient temperature for 2 hours. Tetrahydrofuran and water were added (10:1 , 10 mL), and the mixture extracted three times with dichloromethane. The combined organic layers washed with brine, dried over magnesium sulfate, filtered and concentrated in vacuo. Purification by chromatography using an ISCO CombiFlash Companion MPLC (12 g RediSep Gold column, eluting with 0-50%dichloromethane/methanol) followed by treatment with -pentane, filtration, concentration and purification by ISCO CombiFlash Companion MPLC (15 g Chromabond RP-C18 column, eluting with 0-100% water/methanol) gave the title compound. MS (APCI) m/z 344.2 (M+H)+.

According to the analysis of related databases, 149849-94-5, the application of this compound in the production field has become more and more popular.

Some scientific research about 149849-94-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 149849-94-5, name is Methyl 2-chloropyrimidine-4-carboxylate. A new synthetic method of this compound is introduced below., Recommanded Product: 149849-94-5

To a solution of 2-oxa-6-azaspiro[3.3]heptane hemioxalate (1.04 g) in dioxane (10 mL) was added triethylamine (1.55 mL) and the reaction mixture was stirred for 10 minutes at ambient temperature. Methyl 2-chloropyrimidine-4-carboxylate (500 mg) was added and the reaction mixture was stirred at 80 C for 6 hours in a Biotage Initiator microwave unit. To the reaction mixture was added water and the aqueous phase was extracted twice with ethyl acetate. The combined organic extracts were washed with brine, dried with sodium sulfate, filtered, and concentrated in vacuo. The crude product was used without any further purification in the next step. MS (ESI) m/z 230.4 (M+H)+

The important role of 149849-94-5

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 149849-94-5, Methyl 2-chloropyrimidine-4-carboxylate.

Synthetic Route of 149849-94-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 149849-94-5, name is Methyl 2-chloropyrimidine-4-carboxylate, molecular formula is C6H5ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of methyl 2-chloropyrimindine-4-carboxylate (750 mg, 4.35 mmol) in methanol(20 mL) stirred under nitrogen at 0 C was added sodium borohydride (329 mg, 8.7 mmol)portion-wise. The reaction minxture was allowed to warm to rt and stirred at rt for 2 h. Asaturated solution of ammonium chloride in water (40 mL) and EtOAc (40 mL) were added.After separation, the aqueous layer was extracted with EtOAc (2 x 40 mL). The combined organic layers were washed with brine, dried over sodium sulfate, and evaporated in vacuo to afford a brown oil. This residue was purified by normal phase column chromatography [(EtOHIEtOAc 4: 1)/CyH 0-40%j to afford (2-chloropyrimindin-4-yl)methanol (187 mg, 1.3 mmol, purity: 42 %, recovery: 30 %) as a light yellow solid. LCMS (m/z) 145 and 147 (M+H), retention time: 1.26 min LC/MS Method 1.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; DAUGAN, Alain Claude-Marie; DONCHE, Frederic G.; FAUCHER, Nicolas Eric; GEORGE, Nicolas S.; (243 pag.)WO2018/92089; (2018); A1;,
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The origin of a common compound about Methyl 2-chloropyrimidine-4-carboxylate

According to the analysis of related databases, 149849-94-5, the application of this compound in the production field has become more and more popular.

Application of 149849-94-5, Adding some certain compound to certain chemical reactions, such as: 149849-94-5, name is Methyl 2-chloropyrimidine-4-carboxylate,molecular formula is C6H5ClN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 149849-94-5.

To a solution of methyl 2-chloropyrimidine-4-carboxylate (30.00 g, 173.84 mmol) in dioxane (300 mL) was added TEA (26.39 g, 260.77 mmol) and ()-1-phenylethanamine(25.28 g, 208.61 mmol). After addition, it was heated at 50C for 4 h. TLC indicated that the reaction was completed. The solvent was removed by concentration in vacuo and residue was dissolved in ethyl acetate (200 mL), washed by water (100 mL x 2) and brine (100 mL). The separated organic layer was dried over sodium sulfate, filtered and concentrated. The crude product was purified by silica gel column chromatography (eluted by DCM : MeOH = 60:1)to give desired product as light yellow solid (38.00 g, yield 85.0%).

According to the analysis of related databases, 149849-94-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SHANGHAI METON PHARMACEUTICAL CO., LTD; YANG, Jibin; (67 pag.)WO2018/95344; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia