Category: 150010-20-1

Reference of 150010-20-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.150010-20-1, name is 2-Bromo-5-methylpyrimidine, molecular formula is C5H5BrN2, molecular weight is 173.0106, as common compound, the synthetic route is as follows.

To a mixture of compound 7-3 (80 mg, 0.24 mmol) and 2-bromo-5- methylpyrimidine (46 mg, 0 27 mmol ) in DMT (2 mL) was added potassium carbonate (67 mg, 0.48 mmol) and 18-crown-6 (64 mg, 0.24 mmol) and the mixture was stirred at 100 C for 16 hours. The mixture was diluted with EtOAc and washed with saturated aqueous NEUCl solution and brine, dried over anhydrous NarSCX filtered and concentrated to dryness. The residue was purified by chromatography on silica gel (eluted with PE: EtOAc 2: 1) to afford compound 7-4 (47 mg, yield 45.9 %) as a yellow solid. LC/MS (ESI) m/z: 423 (M+H)?.

Statistics shows that 150010-20-1 is playing an increasingly important role. we look forward to future research findings about 2-Bromo-5-methylpyrimidine.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; GAHHACHANDA, Venkat, Rao; EASTMAN, Kyle, J.; GODWIN, Pais; (611 pag.)WO2020/51532; (2020); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 150010-20-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 150010-20-1, name is 2-Bromo-5-methylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

A flask was charged with trans-4-(tert-butyldimethylsiloxy)- 1 -buten- 1 -ylboronic acid pinacol ester (3.37 mL, 9.61 mmol), cesium carbonate (6.89 g, 21.13 mmol), triphenyiphosphine (1.01 g, 3.84 mmol), 2- bromo-5-methylpyrimidine (1.70 g, 9.80 mmol), ACN (60 mL), and water (15 mL). Argon was bubbled through the reaction mixture. Diacetoxypalladium (0.2 16 g, 0.96 mmol) was then added and Argon was bubbled through the reaction again. The mixture was then heated at 85 C for 16 h. Water was added to the mixture which was then extracted with EtOAc. The EtOAc layer was dried, concentrated, and purified by silica gel column chromatography with gradient hexanes/EtOAc solvent system to give (E)-2- (4-((tert-butyldimethylsilyl)oxy)but- 1-en-i -yl)-5-methylpyrimidine (Example 70.1, 2.3 g 86%) as a yellow oil. LCMS-ESI (pos.) m/z: 279.2 (M+H)t

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 150010-20-1, 2-Bromo-5-methylpyrimidine.

Reference:
Patent; AMGEN INC.; BROWN, Matthew; CHEN, Ning; CHEN, Xiaoqi; CHEN, Yinhong; CHENG, Alan C.; CONNORS, Richard V.; DEIGNAN, Jeffrey; DRANSFIELD, Paul John; DU, Xiaohui; FU, Zice; HARVEY, James S.; HEATH, Julie Anne; HEUMANN, Lars V.; HOUZE, Jonathan; KAYSER, Frank; KHAKOO, Aarif Yusuf; KOPECKY, David J.; LAI, Su-Jen; MA, Zhihua; MEDINA, Julio C.; MIHALIC, Jeffrey T.; OLSON, Steven H.; PATTAROPONG, Vatee; SWAMINATH, Gayathri; WANG, Xiaodong; WANSKA, Malgorzata; YEH, Wen-Chen; (815 pag.)WO2018/97944; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia