Electric Literature of 15018-56-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 15018-56-1, name is 5-Bromo-6-methylpyrimidine-2,4-diol, molecular formula is C5H5BrN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To a mixture of 5-substituted uracils 1(a-c) (1mmol) and ammonium sulfate (0.06mmol, 0.008g), HMDS (4mL) was added and refluxed until the precipitate was dissolved. Then, the solvent was removed under reduced pressure and the resulting oily liquid was dissolved in dry DMF (4mL) and NaH (2mmol, 0.048g) was added at -10C. After stirring of the reaction mixture for 1h, various alkyl halides (1mmol) were added. The progress of the reaction was monitored by TLC using chloroform/methanol as eluent (20:1). After the completion of the reaction, the mixture was neutralized by 2N HCl and extracted by CH2Cl2 (2×30mL). The combined organic phase was dried over Na2SO4 and removed under reduced pressure. The resulting solid was recrystallized in EtOAc and n-hexane.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 15018-56-1, 5-Bromo-6-methylpyrimidine-2,4-diol.
Reference:
Article; Bakavoli, Mehdi; Eshghi, Hossein; Shiri, Ali; Afrough, Toktam; Tajabadi, Javad; Tetrahedron; vol. 69; 39; (2013); p. 8470 – 8476;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia