Category: 150728-13-5

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products, Application In Synthesis of 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2′-bipyrimidine, 150728-13-5, Name is 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2′-bipyrimidine, molecular formula is C15H10Cl2N4O2, belongs to pyrimidines compound. In a document, author is Bellin, Leo, introduce the new discover.

Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase

Aspartate transcarbamoylase (ATC), an essential enzyme for de novo pyrimidine biosynthesis, is uniquely regulated in plants by feedback inhibition of uridine 5-monophosphate (UMP). Despite its importance in plant growth, the structure of this UMP-controlled ATC and the regulatory mechanism remain unknown. Here, we report the crystal structures of Arabidopsis ATC trimer free and bound to UMP, complexed to a transition-state analog or bearing a mutation that turns the enzyme insensitive to UMP. We found that UMP binds and blocks the ATC active site, directly competing with the binding of the substrates. We also prove that UMP recognition relies on a loop exclusively conserved in plants that is also responsible for the sequential firing of the active sites. In this work, we describe unique regulatory and catalytic properties of plant ATCs that could be exploited to modulate de novo pyrimidine synthesis and plant growth. Aspartate transcarbamoylase acts in de novo pyrimidine biosynthesis and in plants is regulated by feedback inhibition via uridine 5-monophosphate (UMP). Here Bellin et al. describe the structural basis for this feedback inhibition, showing that UMP blocks the active site by binding to a plant specific UMP recognition loop.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 150728-13-5. Application In Synthesis of 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2′-bipyrimidine.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

In an article, author is Mansour, S. Y., once mentioned the application of 150728-13-5, Name is 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2′-bipyrimidine, molecular formula is C15H10Cl2N4O2, molecular weight is 349.17, MDL number is MFCD03839838, category is pyrimidines. Now introduce a scientific discovery about this category, Quality Control of 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2′-bipyrimidine.

Synthesis and anticancer assessment of some new 2-amino-3-cyanopyridine derivatives

The 2-Aminonicotinonitrile derivative was reacted with different bi-functional reagents such as formamide, thiourea, acetic anhydride, and phthalic anhydride under optimized conditions to give pyrimidine, thiourea, acetamide, and isoindoline derivatives, respectively, When it was treated with active methylene reagents as malononitrile, phenacyl bromide, and ethyl bromoacetate under varied experimental modulation, it afforded 1, 8-naphthyridine, ethyl, and methylamino nicotinonitrile derivatives, respectively. Also, it was reacted with p-toluene sulfonyl chloride, chloroacetyl chloride, and benzoyl chloride to give sulfonamide, 2-chloro-N-acetamide, and benzamide derivatives, respectively. Likewise, it was reacted with diethyl malonate, ethyl cyanoacetate, and cyano acetic acid to give ethylpropanoate, naphthyridine, and cyano acetamide derivatives, respectively. However, treatment of ethylpropanoate and cyano acetamide derivatives with hydrazine hydrate gave pyrazole and 5-amino-pyrazole nicotinonitrile derivatives, respectively. In addition, it was reacted with p-anisaldehyde, phenyl isocyanate, and triethyl orthoformate to give benzylamino nicotinonitrile, phenyl urea, and N-formamide derivatives, respectively. Furthermore, it was reacted with nitrous acid then coupled with aniline; it was also reacted with isatine and 1,3- dibromo propane to give oxoindoline derivative, and the dimer. Elemental analyses, together with spectroscopic data including IR, H-1-NMR in addition to C-13-NMR and mass spectra submit proofs for the chemical structures for all compounds. [GRAPHICS]

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 150728-13-5, Quality Control of 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2′-bipyrimidine.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 150728-13-5, Name is 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2′-bipyrimidine, molecular formula is C15H10Cl2N4O2, belongs to pyrimidines compound, is a common compound. In a patnet, author is Saberikhah, Elham, once mentioned the new application about 150728-13-5, Formula: C15H10Cl2N4O2.

gamma-Fe2O3@HAp@PBABMD@Cu magnetic nanoparticles: Efficient, green, and recyclable novel nanocatalyst for the synthesis of densely functionalized pyrrole-pyrido[2,3-d]pyrimidine hybrids

A green heterogeneous nanocatalyst, Cu(II)-PBABMD complex immobilized on core-shell magnetic gamma-Fe2O3@HAp, was successfully designed, synthesized, and characterized by FTIR, XRD, FESEM, EDX, VSM, TGA, BET, ICP-OES, and TEM techniques. The magnetic Cu(II) nanocatalyst was employed as a novel, ecofriendly, recyclable, and safe catalyst for the one-pot, three-component condensation of 6-amino-2-thioxo-2,3-dihydropyrimidin-4(1H)-one, 3-(1-methyl-1H-pyrrol-2-yl)-3-oxopropanenitrile and aromatic aldehydes to produce new pyrido[2,3-d]pyrimidine derivatives, in refluxing EtOH with excellent yield (90-97%) and short reaction time (8-13 min). The nanocatalyst was used and recycled in eight runs without significant leaching or loss of its catalytic activity.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 150728-13-5. The above is the message from the blog manager. Formula: C15H10Cl2N4O2.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Synthetic Route of 150728-13-5, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 150728-13-5, Name is 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2′-bipyrimidine, SMILES is ClC1=NC(=NC(=C1OC2=C(C=CC=C2)OC)Cl)C3=NC=CC=N3, belongs to pyrimidines compound. In a article, author is Gein, V. L., introduce new discover of the category.

Synthesis, Structure, and Antibacterial Activity of Alkyl 6-Aroyl-7-aryl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-5-carboxylates

A series of new alkyl 6-aroyl-7-aryl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-5-carboxylates was obtained through the three-component reaction of alkyl esters aroylpyruvic acids with a mixture of aromatic aldehyde and 5-aminotetrazole. All the synthesized compounds were tested for antibacterial activity.

Synthetic Route of 150728-13-5, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 150728-13-5.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 150728-13-5, Name is 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2′-bipyrimidine, SMILES is ClC1=NC(=NC(=C1OC2=C(C=CC=C2)OC)Cl)C3=NC=CC=N3, in an article , author is Naikoo, Rayees Ahmad, once mentioned of 150728-13-5, Name: 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2′-bipyrimidine.

7-Endo-trig Pictet-Spengler type cyclization of 5-alkylidene/arylidene-amino-3H-pyrimidin-4-ones: An efficient and diastereoselective synthesis of pyrimido[4,5-b] [1,4]benzodiazepines

The manuscript describes an efficient, atom economical synthesis of pyrimido[4,5-b][1,4]benzodiazepin-4-ones by relatively unexplored 7-endo-trig Pictet-Spengler type cyclisations. The synthetic methdodlogy involves the synthesis of different variants of 5-arylidene-amino-3H-pyrimidines and their p-toluene sulfonic acid mediated 7-endo-trig Pictet-Spengler type cyclisations to afford biologically relavent functionalized benzodiazepine condensed pyrimidinones such as pyrimido[4,5-b][1,4]benzodiazepines in good to excellent yields (82-94%).

Interested yet? Read on for other articles about 150728-13-5, you can contact me at any time and look forward to more communication. Name: 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2′-bipyrimidine.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Reference of 150728-13-5, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 150728-13-5, Name is 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2′-bipyrimidine, SMILES is ClC1=NC(=NC(=C1OC2=C(C=CC=C2)OC)Cl)C3=NC=CC=N3, belongs to pyrimidines compound. In a article, author is Huang, Kuan-Hsiang, introduce new discover of the category.

Bridging Functional Groups Governing the Charge Transfer Dynamic in an Amorphous Carbon Nitride Allotropic Heterojunction toward Efficient Solar Hydrogen Evolution

Modulation of the charge transfer dynamic in amorphous carbon nitride allotropic heterojunctions by an alternation in bridging functional groups for the heptazine- and triazine-based fragments is demonstrated to boost the photocatalytic activity for hydrogen evolution. Pyrimidine-bridged and NH-bridged amorphous carbon nitride allotropic heterojunctions are synthesized by thermal polycondensation of a supramolecular complex. Due to the improved charge separation efficiency and visible-light harvesting ability, both allotropic heterojunctions present more than tenfold enhanced photocatalytic activities for hydrogen evolution compared to the conventional heptazine-based carbon nitride under visible-light illumination. Moreover, the photocatalytic activity of the NH-bridged carbon nitride allotropic heterojunction with type-II charge transfer dynamic is superior to the pyrimidine-bridged one with a Z-scheme characteristic. The findings in this study emphasize that the electronic structure at the heterojunction interface governed by the bridging group greatly influences the charge transfer dynamic and therefore is a crucial factor driving the photocatalytic activity of carbon nitride allotropic heterojunctions.

Reference of 150728-13-5, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 150728-13-5 is helpful to your research.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 150728-13-5, Name is 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2′-bipyrimidine, molecular formula is , belongs to pyrimidines compound. In a document, author is Liu, Ziwei, COA of Formula: C15H10Cl2N4O2.

Photoredox chemistry in the synthesis of 2-aminoazoles implicated in prebiotic nucleic acid synthesis

Prebiotically plausible ferrocyanide-ferricyanide photoredox cycling oxidatively converts thiourea to cyanamide, whilst HCN is reductively homologated to intermediates which either react directly with the cyanamide giving 2-aminoazoles, or have the potential to do so upon loss of HCN from the system. Thiourea itself is produced by heating ammonium thiocyanate, a product of the reaction of HCN and hydrogen sulfide under UV irradiation.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 150728-13-5, in my other articles. COA of Formula: C15H10Cl2N4O2.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 150728-13-5, Name is 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2′-bipyrimidine, formurla is C15H10Cl2N4O2. In a document, author is Zhang, Jianqing, introducing its new discovery. HPLC of Formula: C15H10Cl2N4O2.

Design, synthesis and biological evaluation of novel 4-(pyrrolo[2,3-d]pyrimidine-4-yloxy)benzamide derivatives as potential antitumor agents

Cancer is a major cause of death worldwide. Small molecule inhibitors have become a major therapeutic treatment for cancer. In this study, a series of novel 4-(pyrrolo[2,3-d]pyrimidine-4-yloxy)benzamide derivatives were designed, synthesized and evaluated for their antitumor activity against the A549, Hela and MCF-7 cell lines. Among them, the optimal compound 35 was found to possess excellent inhibitory activity against the A549, Hela and MCF-7 cell lines with IC50 values of 5.29 +/- 0.58, 3.72 +/- 0.91, and 9.23 +/- 0.56 mu M, which were superior to Golvatinib. The structure-activity relationship showed that the introduction of 7H-pyrrolo[2,3-d] pyrimidine along with the F atom of the central and terminal benzene was beneficial to the improvement of inhibitory activity of the target compounds. Besides, we took further study on the combined mode between compound 35 and c-Met kinase through molecular docking

If you are hungry for even more, make sure to check my other article about 150728-13-5, HPLC of Formula: C15H10Cl2N4O2.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Related Products of 150728-13-5, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 150728-13-5, Name is 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2′-bipyrimidine, SMILES is ClC1=NC(=NC(=C1OC2=C(C=CC=C2)OC)Cl)C3=NC=CC=N3, belongs to pyrimidines compound. In a article, author is Liu, Yingcheng, introduce new discover of the category.

Preparation and photocatalytic activity of pendant heteroaryl groups (pyrimidine and pyridine) grafted polyterthiophene/TiO2 composites

In this paper, new pi-conjugated heterocyclic systems with pyrimidine- and pyridine-grafted polyterthiophene were combined with TiO2 to obtain composite materials (PDTPrT/TiO2 and PDTPrmT/TiO2). The photocatalytic properties of the composites were tested by using them to degrade MB using UV-light and simulated solar irradiation. The structural analysis revealed that the pyrimidine and pyridine groups in the polyterthiophenes interacted with TiO2 via non-covalent interactions. The combination of the substituted polyterthiophene and TiO2 restrained the recombination rate of photogenerated e(-)-h(+) pairs and broadened the spectral response range of TiO2. The results indicated that PDTPrT/TiO2 and PDTPrmT/TiO2 with a TiO2-to-monomer molar ratio of 75 had the highest photodegradation rates under UV light (98.6% and 97.4%, respectively after 10 min) and simulated solar (95.4% and 92.7%, respectively after 300 min).

Related Products of 150728-13-5, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 150728-13-5 is helpful to your research.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 150728-13-5, Name is 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2′-bipyrimidine, SMILES is ClC1=NC(=NC(=C1OC2=C(C=CC=C2)OC)Cl)C3=NC=CC=N3, belongs to pyrimidines compound. In a document, author is Rolly, Nkulu Kabange, introduce the new discover, Category: pyrimidines.

Drought-induced AtbZIP62 transcription factor regulates drought stress response in Arabidopsis

We investigated the role of AtbZIP62, an uncharacterized Arabidopsis bZIP TF, in oxidative, nitro-oxidative and drought stress conditions using reverse genetics approach. We further monitored the expression of AtPYD1 gene (orthologous to rice OsDHODH1 involved in the pyrimidine biosynthesis) in atbzip62 knock-out (KO) plants in order to investigate the transcriptional interplay of AtbZIP62 and AtPYD1. The atbzip62 KO plants showed significant increase in shoot length under oxidative stress, while no significant difference was recorded for root length compared to WT. However, under nitro-oxidative stress conditions, atbzip62 showed differential response to both NO-donors. Further characterization of AtbZIP62 under drought conditions showed that both atbzip62 and atpyd1-2 showed a sensitive phenotype to drought stress, and could not recover after re-watering. Transcript accumulation of AtbZIP62 and AtPYD1 showed that both were highly up-regulated by drought stress in wild type (WT) plants. Interestingly, AtPYD1 transcriptional level significantly decreased in atbzip62 exposed to drought stress. However, AtbZIP62 expression was highly induced in atpyd1-2 under the same conditions. Both AtbZIP62 and AtPYD1 were up-regulated in atnced3 and atcat2 while showing a contrasting expression pattern in atgsnor13. The recorded increase in CAT, POD, and PPO-like activities, the accumulation of chlorophylls and total carotenoids, and the enhanced proline and malondialdehyde levels would explain the sensitivity level of atbzip62 towards drought stress. All results collectively suggest that AtbZIP62 could be involved in AtPYD1 transcriptional regulation while modulating cellular redox state and photosynthetic processes. In addition, AtbZIP62 is suggested to positively regulate drought stress response in Arabidopsis.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 150728-13-5 is helpful to your research. Category: pyrimidines.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia