Category: 1546-78-7

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1546-78-7, name is 4-Hydroxy-6-(trifluoromethyl)pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. name: 4-Hydroxy-6-(trifluoromethyl)pyrimidine

Add 6-(trifluoromethyl)pyrimidin-4-ol (1.5 g, 9.15 mmol) and oxalyl chloride (2.3 mL, 22.9 mmol) to EtOAc (15 mL), then add 5 drops of DMF. Heat the mixture to reflux for 2 hrs. After reaction, partition between EtOAc and brine, separate the organic layer; dry the organic layer over anhydrous Na2S04. Transfer the organic solution to a sealed tube, add a solution of NH3 in methanol (7M, lOmL), seal the tube, heat at 70C for 15 hrs. Cool to room temperature; concentrate under reduced pressure to get the crude product. Purification by chromatography (silica gel, EtOAc_PE=2:l) affords the target compound (920 mg, 61.3%).

With the rapid development of chemical substances, we look forward to future research findings about 1546-78-7.

Reference:
Patent; CROWN BIOSCIENCE INC. (TAICANG); ZHANG, Deyi; ZHANG, Ruihao; ZHONG, Boyu; SHIH, Chuan; WO2014/418; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1546-78-7, name is 4-Hydroxy-6-(trifluoromethyl)pyrimidine, the common compound, a new synthetic route is introduced below. COA of Formula: C5H3F3N2O

To a solution of BE-1 (40.0 g, 244 mmol) in THF (800 mL) is added PPh3 (98.0 g) and NCS (160.0 g). The reaction mixture is stirred at 80 C for 10 h. The mixture is then quenched with water and extracted with EtOAc. The solution is concentrated and the residue is purified by Si02 flash chromatography to yield BE-2.

The synthetic route of 1546-78-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BAKONYI, Johanna; BRUNETTE, Steven Richard; COLLIN, Delphine; HUGHES, Robert Owen; LI, Xiang; LIANG, Shuang; SIBLEY, Robert; TURNER, Michael Robert; WU, Lifen; ZHANG, Qiang; WO2015/160654; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 1546-78-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1546-78-7 as follows.

Take 0.17g (0.001mol) 4- hydroxy-6-trifluoromethyl-pyrimidine (prepared as described in Example 1), 0.23g (0.001mol) 4- chloro-1- (4-chlorophenyl) -1H – pyrazole (prepared as in Example 2), 0.14g (0.001mol) of potassium carbonate in 50ml single neck flask, 10mlN, N- dimethylformamide as a solvent, was heated to 100 deg.] C, the reaction 4-10 hours, TLC after completion of the reaction was monitored, the solvent was distilled off under reduced pressure, was added (3 × 50ml) and extracted with ethyl acetate, the organic phase was washed with saturated brine 50ml, after solvent removal the residue by column chromatography (eluent, ethyl acetate and petroleum ether , a volume ratio of 1: 2) to obtain 0.26 g of a white solid, yield 72.5%,

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1546-78-7, its application will become more common.

Reference:
Patent; Shenyang Sinochem Agrochemicals R&D Co., Ltd.; Sun, Xufeng; Guan, Aiying; Zhao, Jie; Ma, Sen; Sun, Qin; Chen, Xuanming; Liu, Zhangling; (40 pag.)CN105777717; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 1546-78-7, 4-Hydroxy-6-(trifluoromethyl)pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1546-78-7, blongs to pyrimidines compound. name: 4-Hydroxy-6-(trifluoromethyl)pyrimidine

A solution of 6-(trifluoromethyl)pyrimidin-4-ol (5.0 g, 30.5 mmol), phosphoryl chloride (3.41 mL, 36.6 mmol), and quinoline (2.16 mL, 18.3 mmol) in toluene (50 mL) was stirred at 100 C. for 5 h. The reaction was diluted with water and extracted with ethyl acetate three times, dried with sodium sulfate, filtered, and concentrated in vacuo. The crude residue was purified by flash column chromatography (10% EtOAc/Hexane) to yield the desired product (1.20 g, 21.6%). 1H NMR (400 MHz, CDCl3): 9.21 ppm (1H, s), 7.78 (1H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1546-78-7, its application will become more common.

Reference:
Patent; Xue, Chu-Biao; Zheng, Changsheng; Feng, Hao; Xia, Michael; Glenn, Joseph; Cao, Ganfeng.; Metcalf, Brian W.; US2006/4018; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 1546-78-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1546-78-7, name is 4-Hydroxy-6-(trifluoromethyl)pyrimidine, molecular formula is C5H3F3N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation of 6-Trifluoromethyl-pyrimidin-4-ylamine; The procedure was derived from methods described in US 5,756,275 and WO 02/38569. In a 250 mL round bottom flask, 6-trifluorornethyl-4-pyrimidinol (10 g, 60.9 mmol) was dissolved in 70 mL phosphorus oxychloride (0.73 mol). The solution was heated at reflux for 7 h. The cooled reaction solution was then added gradually to 200 mL 30% ammonium hydroxide, and the resulting mixture was stirred overnight at room temperature. The reaction mixture was extracted with ethyl acetate (2 x 100 mL), and the combined extracts were dried (MgSO4) and evaporated in vacuo to give 6-trifluoromethyl-pyrimidin-4-ylami?e (1.4 g, yield 14%) as a white solid. 1H NMR (400 MHz, DMSO-dbeta) delta 8.50 (s, 1 H), 7.60 (broad s, 2 H), 6.90 (s, 1 H); LC-MS m/z 164.1 [M+Hf.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1546-78-7, 4-Hydroxy-6-(trifluoromethyl)pyrimidine.

Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2007/75650; (2007); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 1546-78-7, Adding some certain compound to certain chemical reactions, such as: 1546-78-7, name is 4-Hydroxy-6-(trifluoromethyl)pyrimidine,molecular formula is C5H3F3N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1546-78-7.

Add 6-(trifluoromethyl)pyrimidin-4-ol (1.5 g, 9.15 mmol) and oxalyl chloride (2.3 mL, 22.9 mmol) to EtOAc (15 mL), then add 5 drops of DMF. Heat the mixture to reflux for 2 hrs. After reaction, partition between EtOAc and brine, separate the organic layer; dry the organic layer over anhydrous Na2S04. Transfer the organic solution to a sealed tube, add a solution of NH3 in methanol (7M, lOmL), seal the tube, heat at 70C for 15 hrs. Cool to room temperature; concentrate under reduced pressure to get the crude product. Purification by chromatography (silica gel, EtOAc_PE=2:l) affords the target compound (920 mg, 61.3%).

According to the analysis of related databases, 1546-78-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CROWN BIOSCIENCE INC. (TAICANG); ZHANG, Deyi; ZHANG, Ruihao; ZHONG, Boyu; SHIH, Chuan; WO2014/418; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia