Category: 155-10-2

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.155-10-2, name is 4-Amino-2-chloro-5-fluoropyrimidine, molecular formula is C4H3ClFN3, molecular weight is 147.5381, as common compound, the synthetic route is as follows.SDS of cas: 155-10-2

Step 3. l-(4-Amino-5-fluoro-pyrimidin-2-yl)-3-trifluoromethyl-lH-pyrazole-4-carboxylic acid (adamantan- 1 -ylmethy l)-amide; A solution of 3-trifluoromethyl-lH-pyrazole-4-carboxylic acid (adamantan- 1- ylmethyl)-amide (100 mg, 0.306 mmol), 2-chloro-5-fluoro-pyrimidin-4-ylamine (52 mg, 0.35 mmol) and Cs2CO3 (130 mg, 0.4 mmol) in NMP (1.0 mL) is heated in a microwave reactor at150 C for 1 h. The mixture is poured into H2O. The crude product is filtered out, dissolved in 10% MeOH in DCM, and dried over anhydrous Na2SO4. The title compound is purified byPTLC (eluted with 5% MeOH in DCM). 1H NMR (CD3OD): 8.96 (s, IH), 8.1 l(s, IH), 3.0 (s, 2H), 1.98 (m, 3H), 1.78-1.68 (m, 6H), 1.58 (s, 6H). MS (M+l) = 439.29; Rtau = 1.34 min.*IC50.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,155-10-2, 4-Amino-2-chloro-5-fluoropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; NEUROGEN CORPORATION; WO2009/12482; (2009); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 155-10-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 155-10-2, name is 4-Amino-2-chloro-5-fluoropyrimidine, molecular formula is C4H3ClFN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 95 5-Fluoro-N2-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-pyrimidine-2,4-diamine EXAMPLE 95 was prepared from C-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-yl]-methylamine and 2-chloro-5-fluoro-pyrimidin-4-ylamine: MS (m+1)=394.5.

According to the analysis of related databases, 155-10-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Claiborne, Christopher F.; Butcher, John W.; Claremon, David A.; Libby, Brian E.; Liverton, Nigel J.; Munson, Peter M.; Nguyen, Kevin T.; Phillips, Brian; Thompson, Wayne; McCauley, John A.; US2002/165241; (2002); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 155-10-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 155-10-2, name is 4-Amino-2-chloro-5-fluoropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 4-fluorobenzyl alcohol (2.56 g, 20.3 mmol) in 1,4-dioxane (20 mL) was added 60% NaH (0.813 g, 20.3 mmol) in several portions over a period of 10 min. To the magnetically stirred solution was added 2-Chloro-5-fluoropyrimidin-4-amine* (2.00 g, 13.6 mmol) and the mixture was stirred at room temperature until gas evolution subsided. The reaction mixture was then heated in a CEM Discover microwave reactor at 120 C. for 90 min. The cooled reaction mixture was partitioned between ethyl acetate and water, the organic phase was concentrated, and the product was purified by column chromatography (hexane/ethyl acetate gradient) to yield 5-fluoro-2-(4-fluorobenzyloxy)pyrimidin-4-amine (1.66 g, 52% yield) as a white solid: mp 129-131 C.; 1H NMR (300 MHz, CDCl3) delta 7.91 (d, J=2.6 Hz, 1H), 7.42 (m, 2H), 7.03 (m, 2H), 5.27 (s, 2H), 5.05 (br s, 2H); MS (ESI) m/z 238 (M+H)+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 155-10-2, 4-Amino-2-chloro-5-fluoropyrimidine.

Reference:
Patent; DOW AGROSCIENCES LLC; US2009/203647; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 155-10-2 , The common heterocyclic compound, 155-10-2, name is 4-Amino-2-chloro-5-fluoropyrimidine, molecular formula is C4H3ClFN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirred solution of 4-AMINO-2-CHLORO-5-FLUOROPYRIMIDINE (4.22 g, 28. 6 mmol) in anhydrous THF (60 ml) and anhydrous pyridine (8 ml) under nitrogen was added dropwise over 5 min a solution of DI-TERT-BUTYL dicarbonate (15.60 g, 71. 5 mmol) in THF (10 + 2 ml). The solution was stirred at room temperature under nitrogen for 22.25 h. More DI-TERKBUTYL dicarbonate (3.12 g, 14.3 mmol) in THF (2 + 1 ml) was added and the solution was stirred for a further 3 days. The solvent was removed in vacuo and the residue was purified by flash chromatography, eluting with 15% ETOAC/ISOHEXANE, to leave 14.77 g of a 1: 0. 88 mixture OF DI-TE+BUTYL 2-CHLORO-5-FLUOROPYRIMIDIN-4-YLIMIDODICARBONATE and DI-TE+BUTYL dicarbonate as a white solid.

The synthetic route of 155-10-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2004/65388; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 155-10-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 155-10-2, name is 4-Amino-2-chloro-5-fluoropyrimidine, molecular formula is C4H3ClFN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

10287] 0.15 g (1.01 mmol) of 2-chloro-5-fluoropyrimi- dine-4-amine, 0.249 g (1.22 mmol) of (2-methyl-4,5,6,7- tetrahydrobenzothiophen-4-yl)ammonium chloride and 0.63 g (0.68 ml, 3.05 mol) of dicyclohexylethylamine in 2.0 ml of 1-methyl-2-pyrrolidone are heated at 180 C. in a closed cuvette in the microwave for 90 minutes (l3iotage Initiator, http://www.biotage.comlproduct-page/biotage-initiator).The crude mixture thus obtained is applied to silica gel and purified by column chromatography with heptane/ethyl acetate as mobile phase. Concentration gives 0.072 g of 5-fluoro-N2-(2-methyl-4,5,6,7-tetrahydro- 1 -benzothiophen-4-yl)pyrimidine-2,4-diamine (in waxy form) (22% yield at 85% purity).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 155-10-2, 4-Amino-2-chloro-5-fluoropyrimidine.

Reference:
Patent; Bayer CropScience Aktiengesellschaft; JAKOBI, Harald; MINN, Klemens; BUSCATO ARSEQUELL, Estella; DIETRICH, Hansjoerg; GATZWEILER, Elmar; ROSINGER, Christopher Hugh; SCHMUTZLER, Dirk; (44 pag.)US2018/213780; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia