Category: 156-81-0

156-81-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 156-81-0 as follows.

2-(3-Fluoro-phenyl)-imidazo[1,2-a]pyrimidin-7-ylamine 2-Bromo-1-(3-fluorophenyl)ethanone (10.9 g, 50 mmol) was added to a solution of 2,4-diaminopyrimidine (3.70 g, 34 mmol) in acetone (185 ml), and the mixture was heated to reflux for 6 h. The cooled suspension was filtered and the precipitate was washed with acetone (50 ml). The solid was re-suspended in water (35 ml) and NH4OHaq. (25%, 50 ml), then it was collected over a glass fiber paper and the filtrate was washed with H2O (75 ml). After drying under vacuum, the product was obtained (5.56 g, 72%) as a yellow solid. MS (m/z)=229.1 [M+H+].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,156-81-0, its application will become more common.

Reference:
Patent; Alvarez Sanchez, Ruben; Bleicher, Konrad; Flohr, Alexander; Gobbi, Luca; Groebke Zbinden, Katrin; Koerner, Matthias; Kuhn, Bernd; Peters, Jens-Uwe; Rudolph, Markus; US2011/237564; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

156-81-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 156-81-0, name is Pyrimidine-2,4-diamine, the common compound, a new synthetic route is introduced below.

A solution of 2-bromo-1-(5-chloro-2,4-dimethoxyphenyl)ethanone 3 (140 mg, 0.47 mmol) and pyrimidine-2,4-diamine (50 mg, 0.45 mmol) in acetone (5 mL) was heated to reflux for 16 h. The reaction mixture was cooled to room temperature. The precipitate was filtered and treated with dilute ammonia. Precipitate was filtered, washed with water, and dried under reduced pressure to yield 2-(5-chloro-2,4- dimethoxyphenyl)imidazo[l,2-a]pyrimidin-7-amine 158b ( 95 mg, 36%) as a white solid. 1H NMR (300 MHz, DMSO-d6) delta 8.36 (d, 1H J = 7.2Hz), 8.09 (s, 1H). 7.76 (s, IH), 6.84 (s, IH), 6.76 (s, 2H), 6.22 (d, 1H, J = 7.2Hz), 3.98 (s, 3H), 3.92 (s, 3H); ESI MS m/z 305 [M+H]+

Statistics shows that 156-81-0 is playing an increasingly important role. we look forward to future research findings about Pyrimidine-2,4-diamine.

Reference:
Patent; ONCOTHERAPY SCIENCE, INC.; MATSUO, Yo; HISADA, Shoji; NAKAMURA, Yusuke; CHAKRABARTI, Anjan; RAWAT, Manish; RAI, Sanjay; SATYANARAYANA, Arvapalli, Venkata; DUAN, Zhiyong; TALUKDAR, Arindam; RAVULA, Srinivas; DECORNEZ, Helene; (491 pag.)WO2017/58503; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

156-81-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 156-81-0, name is Pyrimidine-2,4-diamine, molecular formula is C4H6N4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Synthesi -bromopyrimidine-2,4-diamine[00103] To a solution of 2,4-diaminopyrimidine (1.0 g, 9.1 mmol) in chloroform (30 mL) was added N-bromosuccinimide (1.62 g, 9.08 mmol). The solution was stirred in the dark for 12 hours, at which time it was added to CH2C12 (150 mL) and IN NaOH (50 mL). The solid that formed was filtered, rinsed with water and concentrated in vacuo, yielding 1.4 g (74%) of 5-bromopyrimidine-2,4-diamine. LCMS (m/z): 189/191 (MH ). ? NMR (DMSO-^): 5 7.78 (s, 1H), 6.58 (bs, 2H), 6.08 (bs, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 156-81-0, Pyrimidine-2,4-diamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; DANA-FARBER CANCER INSTITUTE, INC.; ZHAO, Jean J.; WANG, Qi; WO2012/109423; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia