Category: 15726-38-2

In 1967,Tetrahedron included an article by Kheifets, G. M.; Khromov-Borisov, N. V.; Kol’tsov, A. I.; Vol’kenhstein, M. V.. Related Products of 15726-38-2. The article was titled 《The proton magnetic resonance spectra and the structure of 4,6-dihydroxypyrimidine and its derivatives》. The information in the text is summarized as follows:

The proton N.M.R. spectra of 4,6-dihydroxypyrimidine and its 2- and 5-substituted derivatives have been compared with the spectra of their O- and N-methyl derivatives of fixed structures, corresponding to possible tautomeric forms. In a Me2SO medium the compounds exist predominantly in the oxohydroxy form. In aqueous solutions of 4,6-dihydroxypyrimidine and its N-methyl derivatives the bipolar-ionic form with delocalized charges probably predominates. 22 references. The experimental process involved the reaction of 5-Bromo-4,6-dihydroxypyrimidine(cas: 15726-38-2Related Products of 15726-38-2)

5-Bromo-4,6-dihydroxypyrimidine(cas: 15726-38-2) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Related Products of 15726-38-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Human spleen dihydroorotate dehydrogenase: a study of inhibition of the enzyme》 was written by Gero, Annette M.; O’Sullivan, William J.; Brown, Desmond. Related Products of 15726-38-2 And the article was included in Biochemical Medicine on August 31 ,1985. The article conveys some information:

Numerous pyrimidine analogs were tested as possible inhibitors of human spleen mitochondrial dihydroorotate dehydrogenase (DHO DHase). Of these, 9 were demonstrated to be effective inhibitors of the enzymic activity. Two compounds, dihydro-5-azaorotate and 6-thiobarbiturate, appeared to be specific inhibitors of the DHO DHase. In addition, 3 compounds, 5-azaorotate, 5-bromoorotate, and barbiturate were also inhibitory against the 2 subsequent enzymes of the pathway, orotate phosphoribosyltransferase and orotidylate decarboxylase, so that they could act against 3 enzymes of the mammalian pyrimidine de novo biosynthetic pathway. In the experiment, the researchers used many compounds, for example, 5-Bromo-4,6-dihydroxypyrimidine(cas: 15726-38-2Related Products of 15726-38-2)

5-Bromo-4,6-dihydroxypyrimidine(cas: 15726-38-2) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Related Products of 15726-38-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 1974,Journal of Organic Chemistry included an article by Banerjee, Sujit; Tee, Oswald S.. Safety of 5-Bromo-4,6-dihydroxypyrimidine. The article was titled 《Bromide ion induced debromination of the 5,5-dibromo derivatives of 4,6-dihydroxy pyrimidine and 6-methyluracil》. The information in the text is summarized as follows:

In aqueous solutions 4,6-dihydroxypyrimidine and 6-methyluracil react rapidly with 2 equiv of Br to yield first the corresponding 5-bromo compounds and second the 5,5-dibromo derivatives Under acidic conditions the latter compounds react with Br-to yield the monobromo derivatives and Br. The liberated Br is consumed in the presence of unreacted substrate to give a second equiv of the 5-bromopyrimidinedione. The kinetics of debromination were measured, and probable mechanisms for these processes were discussed. In the experimental materials used by the author, we found 5-Bromo-4,6-dihydroxypyrimidine(cas: 15726-38-2Safety of 5-Bromo-4,6-dihydroxypyrimidine)

5-Bromo-4,6-dihydroxypyrimidine(cas: 15726-38-2) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Safety of 5-Bromo-4,6-dihydroxypyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application In Synthesis of 5-Bromo-4,6-dihydroxypyrimidineOn November 1, 1989 ,《Inhibition of uridine phosphorylase from Giardia lamblia by pyrimidine analogs》 appeared in Biochemical Pharmacology. The author of the article were Jimenez, Barbara M.; Kranz, Peter; Lee, Choy Soong; Gero, Annette M.; O’Sullivan, William J.. The article conveys some information:

Fifty-six pyrimidine analogs were tested as possible inhibitors of uridine phosphorylase from G. lamblia. Values of Ki were determined for eight of these which demonstrated an inhibition >60% under the standard conditions of uridine at 1 mM (approx. 1.5 times the Km) and inhibitor at 1 mM. All were competitive with respect to uridine. The most effective inhibitors were uracil analogs substituted at the C-5 position with electron-withdrawing groups (nitro groups or halogens). The inhibitory effect at the 5-position appeared to be further enhanced by substitution at the C-6 position with electron-releasing groups. The order of effectiveness as inhibitors was 6-methyl-5-nitrouracil > 6-amino-5-nitrouracil > 5-benzylacyclouridine > 5-nitrouracil > 5-fluorouracil > 5-bromouracil > 6-benzyl-2-thiouracil > 1,3-dimethyluracil, with Ki values of 10, 12, 44, 56, 119, 230, 190 and >1000 μM, resp. The compounds were also effective inhibitors of the thymidine phosphorylase activity of the enzyme. The results are discussed in relation to the use of these pyrimidine analogs to treat G. lamblia infections. The experimental part of the paper was very detailed, including the reaction process of 5-Bromo-4,6-dihydroxypyrimidine(cas: 15726-38-2Application In Synthesis of 5-Bromo-4,6-dihydroxypyrimidine)

5-Bromo-4,6-dihydroxypyrimidine(cas: 15726-38-2) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Application In Synthesis of 5-Bromo-4,6-dihydroxypyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Ylides of heterocycles. VII. Iodonium-, nitrogen-, phosphonium-, and sulfonium-ylides of pyrimidones》 was written by Habib, Nargues Samuel; Kappe, Samuel. SDS of cas: 15726-38-2 And the article was included in Journal of Heterocyclic Chemistry on April 30 ,1984. The article conveys some information:

Reaction of pyrimidinone I (R = OH; R1 = H, Me, Ph, R2 = H; R1 = R2 = Ph; R3 = H) with PhIO prepared in situ gave iodonium ylides I (R = O-, R3 = PhI+; II) in good yield. Thermal rearrangement of II gave I (R = OPh; R3 = iodo), which were deiodinated to give I (R = OPh, R3 = H). Treatment of II with pyridine, nicotinamide, isoquinoline, Ph3P, or thiophene gave the corresponding N, P, or S ylides. The pyridinium ylides were also prepared from I (R = OH, R1 = Br, Cl) which were prepared from II by treatment with HBr or HCl, resp. In the experiment, the researchers used 5-Bromo-4,6-dihydroxypyrimidine(cas: 15726-38-2SDS of cas: 15726-38-2)

5-Bromo-4,6-dihydroxypyrimidine(cas: 15726-38-2) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.SDS of cas: 15726-38-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia