Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 157335-92-7, name is 4-Methylpyrimidine-5-carboxylic acid. A new synthetic method of this compound is introduced below., Computed Properties of C6H6N2O2
6,7,8-substituted-9H-beta-carboline (1 mmol), EDCI (1.6 mmol) and the appropriate carboxylic acid (1.2 mmol) were taken in a round-bottom flask and suspended in pyridine (5 ml). The resulting mixture was heated at 60 C. overnight. The pyridine was then removed by rotary evaporation and 5% Na2CO3 solution was added. The resulting solid that precipitated out was collected by filtration. Chromatographic purification gave the desired product.; Example 2 4-methyl-pyrimidine-5-carboxylic acid (6-chloro-7-methoxy-9H-beta-carbolin-8-yl)-amide The desired compound was prepared according to Method A from 6-chloro-7-methoxy-9H-beta-carbolin-8-ylamine and 4-methyl-5-pyrimidine carboxylic acid in 80% yield. 1H-NMR (300 MHz, DMSO-d6): delta 2.75 (s, 3H), 3.92 (s, 3H), 8.19 (d, 1H), 8.41 (d, 1H), 8.50 (s, 1H), 8.96 (s, 1H), 9.20 (s, 1H), 9.25 (s, 1H), 10.63 (s, 1H), 11.67 (s,1H). Retention Time (LC, method: formic acid standard): 0.95 min. MS (M+H+): 368.
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Reference:
Patent; Millennium Pharmaceuticals, Inc.; US2005/239781; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia