Category: 15846-19-2

Related Products of 15846-19-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 15846-19-2 as follows.

Prepared as described for N-cyclohexyl-4-iodopyridin-3-amine (Intermediate 17), to a stirred solution of 4-chloro-6-meth.oxypyrimidin-5-amine (CAS 15846-19-2; 0.15 g, 0.940 mmol) and cyclohexanone (CAS 108-94-1; 0.294 nil, 2.82 mmol) in anhydrous DCM (5 mL) under an atmosphere of nitrogen at 0 C was added T1CI4 solution (lM in DCM, 3.66 mL, 3.66 mmol). The reaction was stirred at room temperature for 2 h. Sodium triacetoxyborohydride (1.94 g, 9.15 mmol) was added portionwise and the reaction stirred at room temperature for 16 h. The crude product was purified by column chromatography (silica, 0-20% EtOAc / petroleum ether) to afford the title compound.MS ES+: 242

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,15846-19-2, its application will become more common.

Reference:
Patent; DAVENPORT Richard; DUNN Jonathan; FARNABY William; HANNAH Duncan; HARRISON David; WRIGHT Susanne; WO2015/198046; A1; (2015);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15846-19-2, name is 4-Chloro-6-methoxypyrimidin-5-amine, the common compound, a new synthetic route is introduced below. SDS of cas: 15846-19-2

Prepared as described forN-cyclohexyl-4-iodopyridin-3-amine (Intermediate 17), to a stirred solution of 4-chloro-6-methoxypyrimidin-5-amine (CAS 15846-19-2; 200 mg, 1.25 mmol) and cyclopentanone (CAS 120-92-3; 0.33 mL, 3.76 mmol) in anhydrous DCM (6 mL) under an atmosphere of N2at 0 C was added dropwise T1CI4solution (iM in DCM, 1.4 mL, 1.38 mmol). The reaction was stirred at room temperature for 2 h. Sodium triacetoxyborohydride (797 mg, 3.76 mmol) was added portionwise and the reaction stirred at room temperature for 16 h. The crude product was purified by column chromatography (silica, 0-50% EtOAc / petroleum ether) to afford the title compound. 1H NMR (400 MHz, CHLOROFORM-d) 8 ppm 1.33 – 1.53 (m, 2 H) 1.55 – 1.82 (m, 4 H) 1.83 – 2.00 (m, 2 H) 3.73 (d, J=9 Hz, 1 H) 4.04 (s, 3 H) 4.18 – 4.42 (m, 1 H) 8.08 (s, 1 H) MS ES+: 228

The synthetic route of 15846-19-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DAVENPORT Richard; DUNN Jonathan; FARNABY William; HANNAH Duncan; HARRISON David; WRIGHT Susanne; WO2015/198046; A1; (2015);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 15846-19-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.15846-19-2, name is 4-Chloro-6-methoxypyrimidin-5-amine, molecular formula is C5H6ClN3O, molecular weight is 159.57, as common compound, the synthetic route is as follows.

[0708] Isopropylmagnesium bromide (9.4 mL, 4.70 mmol) was added to a stirred mixture of 4-chloro-6-methoxypyrimidin-5-amine (0.50 g, 3.1 mmol, Frontier Scientific Inc., Newark, DE), Pd(dppf)Cl2 (0.23 g, 0.31 mmol), and THF (5 mL), and the resulting mixture was heated at 60 C for 16 h. After cooling, 5 N NaOH was added, and the resulting mixture was extracted with EtOAc (3). The combined extracts were washed with brine, dried over MgSO4, and concentrated in vacuo. Chromatographic purification of the residue (silica gel, 40% EtOAc/heptane) gave 4-isopropyl-6-methoxypyrimidin-5-amine (Intermediate I-39, 482 mg, 91%). 1H NMR (CDCl3) d: 8.18 (s, 1H), 3.92 (s, 3H), 3.57 (br s, 2H), 2.91 (dt, J=13.5, 6.7 Hz, 1H), 1.19 (br d, J=6.8 Hz, 6H). m/z (ESI, +ve ion) 168.1 (M+H)+.

The chemical industry reduces the impact on the environment during synthesis 15846-19-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; AMGEN INC.; ALLEN, John Gordon; ALLEN, Jennifer Rebecca; MINATTI, Ana Elena; XUE, Qiufen; WURZ, Ryan Paul; TEGLEY, Christopher M.; PICKRELL, Alexander J.; NGUYEN, Thomas T.; MA, Vu Van; LOPEZ, Patricia; LIU, Longbin; KOPECKY, David John; FROHN, Michael J.; CHEN, Ning; CHEN, Jian Jeffrey; SIEGMUND, Aaron C.; AMEGADZIE, Albert; TAMAYO, Nuria A.; BOOKER, Shon; GOODMAN, Clifford; WALTON, Mary; NISHIMURA, Nobuko; SHIN, Youngsook; LOW, Jonathan D.; CEE, Victor J.; REED, Anthony B.; WANG, Hui-Ling; LANMAN, Brian Alan; (738 pag.)WO2019/213516; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 15846-19-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 15846-19-2, name is 4-Chloro-6-methoxypyrimidin-5-amine. This compound has unique chemical properties. The synthetic route is as follows.

Example P1 Preparation of STR6 N-(3′-Chloro-2′,6′-dinitro-4′-trifluoromethylphenyl)-5-amino-4-chloro-6-methoxypyrimidine 2.84 g (17.8 mmoles) of 5-amino-4-chloro-6-methoxypyrimidine are dissolved in 20 ml of dimethylsulfoxide. With stirring, a solution of 6.24 g (20.5 mmoles) of 1,3-dichloro-2,6-dinitro-4-trifluoromethylbenzene in 15 ml of dimethylsulfoxide and a solution of 2.30 g (20.5 mmoles) of potassium tert-butylate in 15 ml of dimethylsulfoxide are added simultaneously dropwise at 15 C. The dark red solution so obtained is stirred for 1 hour at 15-20 C. and then poured into ice-water, neutralised with acetic acid and extracted three time with chloroform. The extracts are dried over sodium sulfate and the solvent is removed by rotary evaporation, affording 7.9 g of an oil. This crude product is purified by chromatography through a column of silica gel affording 3.19 g of a crystalline product. Recrystallisation from a mixture of 2 ml of toluene and 8 ml of cyclohexane yields 2.52 g of yellow crystals of m.p. 114-116 C.

According to the analysis of related databases, 15846-19-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Ciba-Geigy Corporation; US4840662; (1989); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 15846-19-2, 4-Chloro-6-methoxypyrimidin-5-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C5H6ClN3O, blongs to pyrimidines compound. HPLC of Formula: C5H6ClN3O

[Reference Example 1]; 4-Chloro-N-(4-chloro-6-methoxy-5-pyrimidinyl)-3-nitrobenzamide; 4-Chloro-3-nitrobenzoic acid (30.2 g, 150 mmol) was suspended in ethyl acetate (150 mL), and thionyl chloride (22 mL, 300 mmol) was added to the resulting suspension. The suspension was then heated under refluxing for 5 hours. The reaction mixture was concentrated under reduced pressure. The residue was concentrated utilizing two portions of dry benzene and two portions of dichloromethane. The resulting acid chloride was dissolved in dichloromethane (20 mL), and the resulting solution was added to a solution of 5-amino-4-chloro-6-methoxypyrimidine (16.0 g, 100 mmol) in dichloromethane (100 mL). The resulting mixture was heated under refluxing for 16 hours. The heated mixture was then cooled to room temperature, and the precipitated crystalline product was collected by filtration and washed with four portions of dichloromethane (20 mL), to obtain 34.3 g (yield 100%) of the titled compound as a white crystalline product. 1H-NMR (CDCl3) delta : 4.07 (3H, s), 7.35 (1H, s), 7.74 (1H, d, J=8Hz), 8.08 (1H, dd, J=2Hz, 8Hz), 8.42 (1H, d, J=2Hz), 8.55 (1H, s).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,15846-19-2, 4-Chloro-6-methoxypyrimidin-5-amine, and friends who are interested can also refer to it.

Reference:
Patent; Nippon Chemiphar Co., Ltd.; EP1757610; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia