Category: 160199-05-3

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 160199-05-3, name is 2,4-Dichlorobenzo[4,5]thieno[3,2-d]pyrimidine, the common compound, a new synthetic route is introduced below. Formula: C10H4Cl2N2S

4,4,5,5-tetramethyl-2- (naphthalen-2-yl) – (4-methylphenyl) pyridine was added to the starting material 2,4-dichlorobenzo [4,5] thieno [3,2- 1,3,2-dioxaborolane (35 g, 138 mmol), Pd (PPh3) 4 (5.80 g, 5.02 mmol), K2CO3 (52 g, 376.41 mmol), THF (440 ml)The temperature of the reaction was raised to 80 DEG C and stirred for 6 hours. After the completion of the reaction, water was removed from the reaction mixture, and the mixture was filtered under reduced pressure, dried over MgSO 4 and concentrated. The resulting compound was purified by silicagel column and recrystallized19.58 g of the product (yield: 45%) was obtained.

The synthetic route of 160199-05-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Duksan Neolux Co.,Ltd.; Samsung Display Co., Ltd.; Yoon Jin-ho; Cho Hye-min; Park Mu-jin; Lee Jeong-uk; Lee Seon-hui; Kim Tae-gyeong; Lee Yun-gyu; Lee Jeong-seop; (41 pag.)KR2018/133276; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 160199-05-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 160199-05-3, name is 2,4-Dichlorobenzo[4,5]thieno[3,2-d]pyrimidine, molecular formula is C10H4Cl2N2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In a round bottom flask, intermediate 1-3 (10 g, 39.2 mmol), (9-phenyl-9H-indazol-2-yl)boronic acid (11.3 g,39.2 mmol), tetrakistriphenylphosphonium (1.4 g, 1.2 mmol), sodium hydroxide (3.9 g, 98 mmol) and tetrahydrofuran (200 mL)Mixed solvent with deionized water (100 mL). The reaction system was heated to reflux at 80 C. After the reaction is completed, it is cooled to room temperature.The reaction solution was diluted with distilled water. The reaction mixture was then extracted with dichloromethane and water.Purification by silica gel chromatography, recrystallization to give intermediate 1-6 (13.6 g, 78%)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 160199-05-3, 2,4-Dichlorobenzo[4,5]thieno[3,2-d]pyrimidine.

Reference:
Patent; Zhejiang Huaxian Optoelectric Technology Co., Ltd.; Zheng Xianzhe; Huang Dong; Hua Wanming; Quan Meizi; Zhao Xiaoyu; (34 pag.)CN109678876; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 160199-05-3, 2,4-Dichlorobenzo[4,5]thieno[3,2-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 160199-05-3, blongs to pyrimidines compound. Computed Properties of C10H4Cl2N2S

General procedure: 2,4-dibromopyrimidine (CAS Registry Number: 3921-01-5) (24.46 g, 102.82 mmol) was added to a round bottom flask and dissolved in THF (360 ml)4,4,5,5-tetramethyl-2- (naphthalen-1-yl-ethyl) -1,3,2-dioxaborolane(CAS Registry Number: 1280709-91-2) (29.54 g, 113.11 mmol),Pd (PPh3) 4 (4.75 g, 4.11 mmol),K2CO3 (42.63 g, 308.47 mmol) and water (180 ml) were addedAnd stirred at 90 C.After the reaction was completed, the reaction mixture was extracted with CH 2 Cl 2 and water. The organic layer was dried over MgSO 4 and concentrated. The resulting compound was purified by silicagel column and recrystallized to obtain 18.03 g (yield: 60%) of the product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,160199-05-3, its application will become more common.

Reference:
Patent; Duksan Neolux Co.,Ltd.; Song Hyeon-ju; Park Mu-jin; Jeong Ho-yeong; Lee Mun-jae; Lee Seon-hui; Kwon Jae-taek; (49 pag.)KR2018/97955; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 160199-05-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 160199-05-3, name is 2,4-Dichlorobenzo[4,5]thieno[3,2-d]pyrimidine. A new synthetic method of this compound is introduced below.

Starting material2,4-dichlorobenzo [4,5] thieno [3,2-d] pyrimidine(32 g, 125.6 mmol)4,4,5,5-tetramethyl-2- (naphthalen-2-yl) -1,3,2-dioxaborolane(35 g, 138 mmol), Pd (PPh3) 4 (5.80 g, 5.02 mmol), K2CO3 (52 g, 376.41 mmol), THF (440 ml), water (220 ml)And the mixture is heated under reflux at 80 C to 90 C.When the reaction is complete, dilute with distilled water at room temperature and extract with methylene chloride and water.The organic layer was dried over MgSO4 and concentrated. The resulting compound was purified by silicagel column and recrystallizationSub 2-61 (19.58 g, yield: 45%) was obtained

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,160199-05-3, its application will become more common.

Reference:
Patent; Duksan Neolux Co.,Ltd.; Jeong Ho-yeong; Ryu Jae-deok; Jeon Jin-bae; Cho Min-ji; (47 pag.)KR2019/1967; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 160199-05-3, Adding some certain compound to certain chemical reactions, such as: 160199-05-3, name is 2,4-Dichlorobenzo[4,5]thieno[3,2-d]pyrimidine,molecular formula is C10H4Cl2N2S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 160199-05-3.

2,4-dichlorobenzo [4,5] thieno [3,2-d] pyrimidine (32 g, 125.6 mmol)(35 g, 138 mmol), 4,4,5,5-tetramethyl-2- (naphthalen-2-yl) -1,3,2-dioxaborolanePd (PPh3) 4 (5.80 g, 5.02 mmol),K2CO3 (52 g, 376.41 mmol), THF (440 mL),Water (220 ml) was added, and the temperature of the reaction product was increased to 80 C, followed by stirring for 6 hours. When the reaction is terminated, water is removed from the reaction,After filtration under reduced pressure, it was dried with MgSO4 and concentrated. The resulting compound was purified by silicagel column and recrystallized to obtain 19.58 g (yield: 45%) of the product.

According to the analysis of related databases, 160199-05-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Duksan Neolux Co.,Ltd.; Yoon Jin-ho; Jeong Ho-yeong; Park Mu-jin; Kim Jeong-seok; Lee Seon-hui; (46 pag.)KR2018/128292; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 160199-05-3, name is 2,4-Dichlorobenzo[4,5]thieno[3,2-d]pyrimidine, the common compound, a new synthetic route is introduced below. Product Details of 160199-05-3

2000 mL round bottom flask 25.0 g intermediate A ( 98.5 mmol ) , phenyl-3 – Boro Nick ester – carbazole 40.01 g (108.35 mmol, dealer : Beijing Green Technology Guardee) , potassium carbonate 34.04 g (246.26 mmol), Pd ( PPh3) 4(Tetrakis (triphenylphosphine)? Palladium (0)) 5.7 g (4.93 mmol) and 1,4- dioxane 600 mL , placed in 300 mL waterGave was then heated to reflux for 6 hours in a nitrogen stream . Inflicting a mixture obtained therefrom in 1500 mL of methanolAfter filtration over a solid crystallized , it was dissolved in monochlorobenzene , and filtered through a silica gel / Celite , an appropriate amount of an organic solventAfter removal , by re-crystallization with methanol to give the intermediate 16 – A ( 31.85 g , yield 70% ) .

The synthetic route of 160199-05-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Samsung SDI co . Ltd; Samsung Electronics Co., Ltd.; Kim, Byeong Gu; Jong, Ho Gook; Han, Soo Jin; Kwon, Oh Hyeon; Kim, Young-Gwon; Kim, Chang Woo; Kim, Heong Son; Seo, Ju Hui; Shin, Chang Joo; Yu, Eun Son; Lee, Seung-Jae; Choe, Byeong Gi; Hwang, Gyu Young; (229 pag.)KR2015/84657; (2015); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 160199-05-3, name is 2,4-Dichlorobenzo[4,5]thieno[3,2-d]pyrimidine. A new synthetic method of this compound is introduced below., COA of Formula: C10H4Cl2N2S

Compound sub 1 (30 g, 118 mmol) andThe compound sub 2 (29 g, 118 mmol) was dispersed in tetrahydrofuran (300 mL), and a 2M potassium carbonate aqueous solution (aq. K2CO3) (176 mL, 352 mmol) was added. Tetraquistriphenylphosphinopalladium Pd (PPh3) 4] (1.4 g, 1 mol%) was added thereto, followed by stirring under reflux for 12 hours. The temperature was lowered to room temperature and the resulting solid was filtered. percolationThe resulting solid was recrystallized from tetrahydrofuran and ethyl acetate, filtered and then dried to give compound H2 (35 g, yield 71%)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 160199-05-3, 2,4-Dichlorobenzo[4,5]thieno[3,2-d]pyrimidine.

Reference:
Patent; LG Chem, Ltd.; Jeong Min-u; Lee Dong-hun; Moon Jeong-uk; Park Tae-yun; Lee Jeong-ha; Cho Seong-mi; Chae Mi-yeong; (43 pag.)KR2018/10166; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 160199-05-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.160199-05-3, name is 2,4-Dichlorobenzo[4,5]thieno[3,2-d]pyrimidine, molecular formula is C10H4Cl2N2S, molecular weight is 255.1232, as common compound, the synthetic route is as follows.

70.0 g (274.4 mmol) of Intermediate B, 33.5 g (274.4 mmol) of phenylboronic acid, 94.8 g (686.0 mmol) of potassium carbonate, and 15.9 g (13.7 mmol) of tetrakis (triphenylphosphine) palladium (0) were added to 800 mE of 1 ,4-dioxane and 400 mE of water in a 2000 mE flask, and the mixture was heated under a nitrogen flow for 24 hours at 50 C. The obtained mixture was added to 3000 mE of methanol, and a solid crystallized therein was filtered, dissolved in monochlorobenzene, filtered with silica gel/Celite, and then, recrystallized with methanol afier removing an appropriate amount of an organic solvent to obtain Intermediate 13-2-1 (59.4 g, yield of 73%). calcd. C16H9C1N2S: C, 64.75; H, 3.06; Cl, 11.95; N, 9.44; 5, 10.80; found: C, 64.70; H, 3.02; Cl, 11.93; N, 9.40; 5, 10.73.

The chemical industry reduces the impact on the environment during synthesis 160199-05-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; SAMSUNG SDI CO., LTD.; KANG, Dong Min; KIM, Youngkwon; KIM, Changwoo; YU, Eun Sun; LEE, Byoungkwan; LEE, Hanill; JUNG, Sung-Hyun; JEONG, SooYoung; JUNG, Ho Kuk; (72 pag.)US2018/26205; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia