Category: 160377-42-4

On October 30, 2020, Yang, Chuluo; Ni, Fan published a patent.Electric Literature of 160377-42-4 The title of the patent was Chiral organic luminescent material and application thereof in electronic device. And the patent contained the following:

The title chiral organic luminescent material has a structural formula I as shown in claim 1, wherein A1 is alkenyl alkynyl, amino, etc.; A2 is alkenyl alkynyl, amino, etc.; R1-R3 are independently selected from hydrogen, deuterium, etc.; and A1, A2, R1, R2 and R3 are not connected or bonded via covalent bonds. The charge transfer-state chiral organic luminescent material with a D-A structure is formed by introducing a suitable electron acceptor (A) into chiral dihydroindenoacridine as an electron donor (D). The chiral dihydroindenoacridine as the D has large steric hindrance, is favorable for forming large torsion between D and A so as to reduce overlap of frontier mol. orbits, to further reduce the singlet-triplet energy level difference (ΔEST), activate the reverse intersystem crossing process so as to realize delayed fluorescence emission, and improve the exciton utilization rate of the device. The rigid chiral quaternary carbon in the chiral dihydroindenoacridine can enable the chiral organic light-emitting material to have circularly polarized luminescent properties, so that an organic electroluminescent device based on the chiral dihydroindenoacridine has circularly polarized luminescent properties, and effective guarantee is provided for electroluminescence to pass through a quarter-wave plate and a polarizing plate. The chiral organic luminescent material can be applied to electronic devices such as the organic light-emitting device, organic solar cell, organic field effect transistor, organic light emitting field-effect transistor, organic laser, organic sensor or organic spin electronic device. The experimental process involved the reaction of 5-(4-Bromophenyl)pyrimidine(cas: 160377-42-4).Electric Literature of 160377-42-4

The Article related to chiral organic luminescent material preparation oled, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Electric Literature of 160377-42-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On July 14, 2017, Zhang, Zhaochao; Tang, Dandan; Li, Chong published a patent.Reference of 5-(4-Bromophenyl)pyrimidine The title of the patent was Organic compound based on triazine and benzimidazole as core and application in organic electroluminescence device. And the patent contained the following:

The invention disclosed a kind of organic compound based on triazine and benzimidazole as core, its preparation method and application in organic electroluminescence device. The claimed compound is shown in structure I (x = 1 or 2; z = 1 or 2; m,n = 0, 1, or 2, and m+n+z = 3; Ar1,Ar2,Ar3 = C1-10 alkyl, or halogen atom, protium, deuterium, tritium substituted or unsubstituted Ph, naphthyl, di-Ph or pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, dibenzofuran, etc.; R1 = C1-10 alkyl, or halogen atom, protium, deuterium, tritium substituted or unsubstituted Ph, naphthyl, etc.; R2,R3 = (un)substituted benzoimidazoyl). The claimed compound is prepared via coupling etc. multiple steps (procedure given). The prepared compound has higher glass transition temperature and mol. thermal stability, low absorption and high refractive index in visible light field, and light extraction efficiency of OLED device can be effectively improved after the compound is applied to the CPL layer of OLED device. The prepared compound also has deep HOMO energy level and high electron mobility, and can be used as hole blocking / electron transport layer material for OLED device to effectively block hole or energy from being transmitted to the electron layer side from the luminescent layer, thus improving recombination efficiency of hole and electron in the luminescent layer so as to improve luminous efficiency and service life of OLED device. The experimental process involved the reaction of 5-(4-Bromophenyl)pyrimidine(cas: 160377-42-4).Reference of 5-(4-Bromophenyl)pyrimidine

The Article related to triazine benzimidazole based core derivative preparation coupling green oled, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Reference of 5-(4-Bromophenyl)pyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On January 31, 2017, Wakiyama, Yoshinari; Kumura, Ko; Umemura, Eijiro; Masaki, Satomi; Ueda, Kazutaka; Sato, Yasuo; Watanabe, Takashi; Hirai, Yoko; Ajito, Keiichi published an article.Category: pyrimidines The title of the article was Synthesis and structure-activity relationships of novel lincomycin derivatives part 3: discovery of the 4-(pyrimidin-5-yl)phenyl group in synthesis of 7(S)-thiolincomycin analogs. And the article contained the following:

Novel lincomycin derivatives possessing an aryl Ph group or a heteroaryl Ph group at the C-7 position via sulfur atom were synthesized by Pd-catalyzed cross-coupling reactions of 7(S)-7-deoxy-7-thiolincomycin with various aryl halides. This reaction is the most useful method to synthesize a variety of 7(S)-7-deoxy-7-thiolincomycin derivatives On the basis of anal. of structure-activity relationships of these novel lincomycin derivatives, the authors found that (a) the location of basicity in the C-7 side chain was an important factor to enhance antibacterial activities, and (b) compounds 22, 36, 42, 43 and 44 had potent antibacterial activities against a variety of Streptococcus pneumoniae with erm gene, which cause severe respiratory infections, even compared with the authors’ C-7-modified lincomycin analogs (1-4) reported previously. Furthermore, 7(S)-configuration was found to be necessary for enhancing antibacterial activities from comparison of configurations at the 7-position of 36 (S-configuration) and 41 (R-configuration). The experimental process involved the reaction of 5-(4-Bromophenyl)pyrimidine(cas: 160377-42-4).Category: pyrimidines

The Article related to structure activity lincomycin derivative, Microbial, Algal, and Fungal Biochemistry: Antimicrobial Sensitivity and other aspects.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On August 31, 2017, Wakiyama, Yoshinari; Kumura, Ko; Umemura, Eijiro; Ueda, Kazutaka; Watanabe, Takashi; Yamada, Keiko; Okutomi, Takafumi; Ajito, Keiichi published an article.Application of 160377-42-4 The title of the article was Synthesis and structure-activity relationships of novel lincomycin derivatives. Part 4: synthesis of novel lincomycin analogs modified at the 6- and 7-positions and their potent antibacterial activities. And the article contained the following:

To modify lincomycin (LCM) at the C-6 and the C-7 positions, we firstly prepared various substituted proline intermediates (7, 11-15 and 17). These proline intermediates were coupled with Me 1-thio-α-lincosamide and tetrakis-O-trimethylsilylation followed by selective deprotection of the TMS group at the 7-position gave a wide variety of key intermediates (23-27, 47 and 50). Then, we synthesized a variety of novel LCM analogs modified at the 7-position in application of the Mitsunobu reaction, an SN2 reaction, and a Pd-catalyzed cross-coupling reaction. Compounds 34 and 35 (1′-NH derivatives) exhibited enhanced antibacterial activities against resistant pathogens with erm gene compared with the corresponding 1′-N-Me derivatives (3 and 37). On the basis of reported SAR, we modified the 4′-position of LCM derivatives possessing a 5-(2-nitrophenyl)-1,3,4-thiadiazol-2-yl group at the C-7 position. Compound 56 showed significantly potent antibacterial activities against S. pneumoniae and S. pyogenes with erm gene, and its activities against S. pneumoniae with erm gene were improved compared with those of 34 and 57. Although we synthesized novel analogs by transformation of a C-7 substituent focusing on the 1′-demethyl framework to prepare very potent analogs 73 and 75, it was impossible to generate novel derivatives exhibiting stronger antibacterial activities against S. pneumoniae with erm gene compared with 56. The experimental process involved the reaction of 5-(4-Bromophenyl)pyrimidine(cas: 160377-42-4).Application of 160377-42-4

The Article related to lincomycin derivative analog antibacterial activity, Microbial, Algal, and Fungal Biochemistry: Antimicrobial Sensitivity and other aspects.Application of 160377-42-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On December 3, 2021, Guo, Jianhua; Li, Mengru; Lu, Ying; Sun, Yue published a patent.Recommanded Product: 160377-42-4 The title of the patent was Preparation of compounds containing benzo five membered heterocycles and organic electroluminescent devices. And the patent contained the following:

The invention discloses a preparation of compounds containing benzo five membered heterocycles and organic electronic devices, which improves the luminous efficiency of the device and prolongs the service life of the device. The compounds containing benzo five membered heterocycles were shown in formula I, Y is selected from any one of O atom, S atom, C (Rx) 2 and N(Ry); the Rx and Ry are the same or different from each other, and are independently selected from hydrogen, deuterium, cyano, nitro, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C3-C12 cycloalkyl, substituted or unsubstituted C6-C30 aryl, substituted or unsubstituted C3-C30 heteroaryl any one of the rings formed by the condensation of the substituted or unsubstituted aliphatic ring of C3- C30 and the aromatic ring of C6- C30; the two adjacent Rx can be connected to form a substituted or unsubstituted ring, or any of Rx and Ry can be directly bonded with L0; when the Rx and Ry are directly bonded with L0, the Rx and Ry are independently selected from any one of single bond, substituted or unsubstituted C6-C30 arylene, substituted or unsubstituted heteroarylene; the Z is selected from any one of O atom and S atom; the Ar1 is selected from substituted or unsubstituted C3-C12 cycloalkyl, substituted or unsubstituted C3-C12 heterocycloalkyl, etc. The title compound was prepared by a multi-step reaction. The invention discloses an organic electroluminescent device, which comprises the components containing benzo five member heterocycles. The experimental process involved the reaction of 5-(4-Bromophenyl)pyrimidine(cas: 160377-42-4).Recommanded Product: 160377-42-4

The Article related to benzo five membered heterocycle organic electroluminescent device suzuki coupling, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Recommanded Product: 160377-42-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Ruch, Jonas; Aubin, Ariane; Erbland, Guillaume; Fortunato, Audrey; Goddard, Jean-Philippe published an article in 2016, the title of the article was Metal-free arylation of pyrimidines through a photochemical process.Reference of 5-(4-Bromophenyl)pyrimidine And the article contains the following content:

Pyrimidinyl and pyrazinyl radicals were generated under moderate energetic irradiation conditions (UVA), and proved to be prompt to undergo C-C bond formation processes. Hetero-biaryl derivatives were obtained in good to high yields with highly interesting functional group selectivities. Bis hetero-biaryls were also easily accessible leading to original compounds, ready for further transformations. Experiments supporting radical processes were reported. The experimental process involved the reaction of 5-(4-Bromophenyl)pyrimidine(cas: 160377-42-4).Reference of 5-(4-Bromophenyl)pyrimidine

The Article related to pyrimidine arene photoarylation, arylpyrimidine regioselective preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Reference of 5-(4-Bromophenyl)pyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On July 14, 1998, Murugesan, Natesan; Barrish, Joel C.; Stein, Philip D. published a patent.Electric Literature of 160377-42-4 The title of the patent was Preparation of substituted biphenyl sulfonamides as endothelin antagonists. And the patent contained the following:

The title compounds [I; X, Y = N, O; R1, R2 = H, alkyl, alkoxy, OH, etc.; R3, R4 = H, alkyl, alkenyl, alkynyl, alkoxy, etc.; R5 = alkyl, alkenyl, alkynyl, etc.; R11-R14 = H, alkyl, alkenyl, alkoxy, etc.; J, K, T, U = N, C; p = 0-2] are prepared I are useful as endothelin antagonists for the treatment of endothelin-related disorders, hypertension, ischemia, atherosclerosis and related diseases (no data). Thus, N-(3,4-dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-4′-(2-pyrimidinyl)-(1,1′-biphenyl)-2-sulfonamide (preparation given) was treated with aqueous HCl to provide 87% the title compound (II). The experimental process involved the reaction of 5-(4-Bromophenyl)pyrimidine(cas: 160377-42-4).Electric Literature of 160377-42-4

The Article related to sulfonamide biphenyl preparation endothelin antagonist, disorder hypertension ischemia atherosclerosis treatment sulfonamide, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Electric Literature of 160377-42-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On March 4, 2022, Li, Jian; Li, Jiaming; He, Runfa; Liu, Jiasheng; Liu, Yang; Chen, Lu; Huang, Yubing; Li, Yibiao published an article.Related Products of 160377-42-4 The title of the article was Selective Synthesis of Substituted Pyridines and Pyrimidines through Cascade Annulation of Isopropene Derivatives. And the article contained the following:

Diverse substituted pyridines I (R = H, Me; R1 = n-Bu, thiophen-2-yl, 4-chlorophenyl, etc.) and pyrimidines II with high selectivity were obtained using a concise and efficient protocol. The reaction proceeds via metal-free cascade annulation of isopropene derivatives R1C(=CH2)CH2R. Using isopropene derivatives as C3 synthons, NH4I as the “N” source, and formaldehyde or DMSO as the carbon source, this reaction realizes the efficient formation of intermol. C-N and C-C bonds. The experimental process involved the reaction of 5-(4-Bromophenyl)pyrimidine(cas: 160377-42-4).Related Products of 160377-42-4

The Article related to methylpyridine preparation, pyrimidine preparation, isopropene formaldehyde tandem heterocyclization, dimethyl sulfoxide isopropene tandem heterocyclization, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Related Products of 160377-42-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Hou, Gui-Ge; Zhao, Hui-Juan; Sun, Ju-Feng; Lin, Dong; Dai, Xian-Ping; Han, Jing-Tian; Zhao, Hui published an article in 2013, the title of the article was Synthesis, structure and luminescence of Co-crystals with hexagonal channels: arranging disposition and π-π interactions.Synthetic Route of 160377-42-4 And the article contains the following content:

Co-crystallization of asym. building blocks 5-(4-pyridyl)pyrimidine (A) and 5-(4-(1-imidazolyl)phenyl)pyrimidine (B) with resorcinol and hydroquinone, resp., was studied. Four new organic co-crystals (1-4) were generated. The x-ray single crystal anal. indicates that the crystal packing in 1, 2 and 4 generates open hexagonal channels with resorcinol or hydroquinone mols. encapsulated through hydrogen bonding interactions. In 3, {B2(resorcinol)2} macrocycle is generated from clip-like resorcinol and asym. B mols. The luminescent properties of A, B and 1-4 were studied primarily in the solid state. The luminescent property is dependent on the mol. vertical arranging disposition and the intermol. π-π contacting characteristic. The results display more interesting tunability of the emission intensity of the building modules by the incorporation of coformers into the co-crystals. The experimental process involved the reaction of 5-(4-Bromophenyl)pyrimidine(cas: 160377-42-4).Synthetic Route of 160377-42-4

The Article related to preparation structure luminescence cobalt crystal hexagonal arranging disposition, Physical Organic Chemistry: Acid-Base, Tautomerism, and Other Equilibrium Studies and other aspects.Synthetic Route of 160377-42-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On March 20, 2003, Neya, Masahiro; Sawada, Akihiko; Ohne, Kazuhiko; Abe, Yoshito; Mizutani, Tsuyoshi; Ishibashi, Naoki; Inoue, Makoto published a patent.COA of Formula: C10H7BrN2 The title of the patent was Preparation of 2-(thiophenyl)thiopyran-1,1-dioxides as MMP or TNF-α inhibitors. And the patent contained the following:

Title compounds I [wherein R1 = (un)substituted Ph, naphthyl, bicyclic heterocyclyl, alkenyl, or alkynyl; R2 = CO2H or protected CO2H; or a salt thereof] were prepared as matrix metalloproteinase (MMP) or tumor necrosis factor α (TNF-α) inhibitors. For example, coupling of 2-(trimethylsilyl)ethyl (S)-[2-(5-bromothiophen-2-yl)-1,1-dioxo-3,4,5,6-tetrahydro-2H-thiopyran-2-yl]acetate and 2-(4′-cyano-4-biphenylyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane followed by deesterification gave II. Five compounds of the invention were tested for gelatinolytic activity against human MMP-9 and displayed inhibitory activity with IC50 values ranging from 1.37 nM to 16.0 nM. Thus, I are useful for treating and/or preventing diseases mediated by MMP or TNF-α (no data). The experimental process involved the reaction of 5-(4-Bromophenyl)pyrimidine(cas: 160377-42-4).COA of Formula: C10H7BrN2

The Article related to thiophenyl thiopyrandioxide preparation mmp tnf inhibitor, Heterocyclic Compounds (One Hetero Atom): Thiopyrans and Areno- and Diarenothiopyrans and other aspects.COA of Formula: C10H7BrN2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia