Category: 16097-60-2

Adding a certain compound to certain chemical reactions, such as: 16097-60-2, 2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine, blongs to pyrimidines compound. Application In Synthesis of 2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine

A mixture of 0.3 g (1.5 mmol) of 2-amino-4-chloro-6-trifluoromethylpyrimidine, 0.3 g (1.5 mmol) of (1R,2S)-2,6-dimethyl-2,3-dihydro-1H-inden-1-aminium chloride and 0.53 g (3.8 mmol) of potassium carbonate in 3 ml of dimethylformamide is heated at 120 C. for 5 hours. After cooling, the reaction mixture is adsorbed on silica gel and purified by means of column chromatography using ethyl acetate/heptane as eluent. Following concentration by evaporation, 0.24 g of solid N4[(1R,2S)-2,6-dimethyl-2,3-dihydro-1H-inden-1-yl]-6-(trifluoromethyl)pyrimidine-2,4-diamine is obtained (44% yield, 90% purity).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,16097-60-2, 2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; BAYER CROPSCIENCE AG; US2010/167935; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 16097-60-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 16097-60-2, name is 2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

Example 11 N4-{3-Fluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)amino]phenyl}-6-(trifluoromethyl)pyrimidine-2,4-diamine 123 mg (480 mmol) of 2-fluoro-N1-(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)benzene-1,4-diamine and 123 mg (620 mumol) of 4-chloro-6-(trifluoromethyl)pyrimidine-2-amine are suspended in 3.5 ml of water. 620 mul of 1 M hydrochloric acid are added, and the mixture is heated at 100 C. overnight. Using 1N aqueous sodium hydroxide solution, the suspension is then adjusted to pH 10, resulting in the precipitation of crystals. The solid is filtered off and washed with water. The crude product is purified by column chromatography on silica gel (mobile phase: dichloromethane/methanol (7 M ammonia) 100:1 to 10:1). Yield: 154 mg (77% of theory) LC-MS (Method 3): Rt=1.38 min. MS (ESI pos.): m/z=418 (M+H)+. 1H-NMR (DMSO-d6, 300 MHz): delta=2.45 (s, 3H), 6.02-6.10 (m, 1H), 6.38 (s, 1H), 6.88-7.03 (m, 3H), 7.24-7.39 (m, 2H), 7.43 (s, 1H), 7.79 (d, 1H), 8.08 (d, 1H), 9.78 (s, 1H), 11.0 (s, 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 16097-60-2, 2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine.

Reference:
Patent; Bayer HealthCare AG; US2008/269268; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 16097-60-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16097-60-2, name is 2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine. A new synthetic method of this compound is introduced below.

Example 8 N4-[3-Fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)phenyl]-6-(trifluoromethyl)pyrimidine-2,4-diamine 32 mg (0.11 mmol) of 3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)aniline and 26 mg (0.12 mmol) of 4-chloro-6-(trifluoromethyl)pyrimidine-2-amine are suspended in 5 ml of water and 0.07 ml of 2N hydrochloric acid. The reaction mixture is heated at reflux for 20 hours. After cooling, the mixture is made alkaline using dilute aqueous sodium hydroxide solution, a little methanol is added and the mixture is extracted with ethyl acetate. The extract is dried over sodium sulfate and the solvent is removed under reduced pressure. The residue is purified by preparative HPLC. Yield: 24 mg (55% of theory) LC-MS (Method 2): Rt=2.05 min. MS (ESI pos.): m/z=403 [M+H]+. 1H-NMR (DMSO-d6-, 400 MHz): S=4.18 (s, 2H), 6.33 (s, 1H), 6.51 (dd, 1H), 6.82 (d, 1H), 6.93 (br. s, 2H), 7.21-7.29 (m, 2H), 7.41 (dd, 1H), 7.89 (dd, 1H), 8.11 (d, 1H), 9.72 (s, 1H), 11.60 (br. s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16097-60-2, its application will become more common.

Reference:
Patent; Bayer HealthCare AG; US2008/269268; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 16097-60-2 ,Some common heterocyclic compound, 16097-60-2, molecular formula is C5H3ClF3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 21 4-(4-{[2-Amino-6-(trifluoromethyl)pyrimidin-4-yl]amino}-2-fluorobenzyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile 82 mg (0.31 mmol) of 4-(4-amino-2-fluorobenzyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile and 67 mg (0.34 mmol) of 4-chloro-6-trifluoromethylpyrimidine-2-amine are suspended in 3 ml of water, 1.5 ml of ethanol and 0.15 ml of 4N hydrochloric acid. The reaction mixture is heated at reflux for 2 hours. After cooling, the mixture is made alkaline using dilute aqueous sodium hydroxide solution, a little methanol is added, the mixture is extracted with ethyl acetate and the solvent is removed under reduced pressure. The residue is purified by preparative HPLC. This gives crystals. Yield: 111 mg (65% of theory) LC-MS (Method 3): Rt=2.34 min. MS (ESI pos.): m/z=428 [M+H]+. 1H-NMR (DMSO-d, 300 MHz): delta=4.41 (s, 2H), 6.35 (s, 1H), 6.90 (d, 1H), 6.96 (br. s, 2H), 7.14 (t, 1H), 7.32 (dd, 1H), 7.93 (dd, 1H), 8.29 (d, 1H), 8.46 (s, 1H), 9.77 (s, 1H), 12.86 (br. s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16097-60-2, its application will become more common.

Reference:
Patent; Bayer HealthCare AG; US2008/269268; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 16097-60-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.16097-60-2, name is 2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine, molecular formula is C5H3ClF3N3, molecular weight is 197.55, as common compound, the synthetic route is as follows.

A. Preparation of 2-Amino-4-(trifluoromethyl)-6-(2,2,2-trifluoroethoxy)-pyrimidine 2,2,2-Trifluoroethanol (2.2 mL, 30 mmol) was slowly added to a suspension of NaH (1.5 g, 36 mmol, 60% dispersion in mineral oil) in anhydrous THF (50 mL) under an N2 atmosphere. To the resulting mixture was added a solution of 2-amino-4-chloro-6-trifluoromethylpyrimidine (5.0 g, 25 mmol; for preparation see: Giner-Sorolla, A. and Bendich, A. J. Am. Chem. Soc. 1957, 80, 5744 and Gershon, H. et al. J. Het. Chem. 1983, 20, 219) in anhydrous THF (50 mL). The resulting mixture was stirred 18 h at room temperature and the solvent evaporated. The resulting residue was partitioned between CH2Cl2 (200 mL) and H2O (200 mL). The organics separated, dried over MgSO4, filtered and evaporated to afford 2-amino-4-(2,2,2-trifluoroethoxy)-6-trifluoromethyl-pyrimidine as a tan solid (4.9 g, 74% yield): m.p. 108-110 C.; 1H NMR (CDCl3) delta 6.54 (s, 1H), 5.53 (bs, 2H), 4.76 (q, 2H, J=8.2 Hz); GCMS (EI, 70 eV) m/z 261 (M+).

Statistics shows that 16097-60-2 is playing an increasingly important role. we look forward to future research findings about 2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine.

Reference:
Patent; Dow AgroSciences LLC; US2009/93486; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.16097-60-2, name is 2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine, molecular formula is C5H3ClF3N3, molecular weight is 197.55, as common compound, the synthetic route is as follows.Formula: C5H3ClF3N3

Example 19 N4-{4-[(3-Chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)methyl]-3-fluorophenyl}-6-(trifluoromethyl)pyrimidine-2,4-diamine 185 mg (0.60 mmol) of 4-[(3-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)methyl]-3-fluoroaniline and 130 mg (0.66 mmol) of 4-chloro-6-(trifluoromethyl)pyrimidine-2-amine are suspended in 4 ml of water and 0.30 ml of 4N hydrochloric acid. The reaction mixture is heated at reflux for 2 hours. After cooling, the mixture is made alkaline using dilute aqueous sodium hydroxide solution, a little methanol is added and the mixture is extracted with ethyl acetate. The extract is dried over sodium sulfate and the solvent is removed under reduced pressure. The residue is purified by preparative HPLC. This gives crystals. Yield: 123 mg (45% of theory) LC-MS (Method 1): Rt=2.32 min. MS (ESI pos.): m/z=437 [M+H]+. 1H-NMR (DMSO-d6, 400 MHz): delta=4.47 (s, 2H), 6.35 (s, 1H), 6.76 (d, 1H), 6.94 (br. s, 2H), 7.03 (t, 1H), 7.29 (dd, 1H), 7.64 (s, 1H), 7.93 (dd, 1H), 8.18 (d, 1H), 9.75 (s, 1H), 12.00 (s, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,16097-60-2, 2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Bayer HealthCare AG; US2008/269268; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 16097-60-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16097-60-2, name is 2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine. A new synthetic method of this compound is introduced below.

Under an ice bath, add 2-amino-4-chloro-6-trifluoromethylpyrimidine (197.0 mg, 1.0 mmol), N-tert-butoxycarbonyl-1,3-propanediamine (208.8 mg, 1.2 mmol) , Dissolved in methanol (8.0 ml), and stirred at reflux overnight. The solvent was recovered under reduced pressure to obtain a residue, which was purified by silica gel column chromatography. PE: EA (5: 1-2: 1) was first used as eluent to obtain 1-36 as a white solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,16097-60-2, 2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Zhejiang University; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Liu Tao; Li Jia; Dong Xiaowu; Zhou Yubo; Hu Yongzhou; Wang Peipei; Jin Tingting; Liu Jieyu; Hu Xiaobei; (51 pag.)CN110872277; (2020); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia