Category: 16234-10-9

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 16234-10-9, name is Thieno[3,2-d]pyrimidin-4(3H)-one. This compound has unique chemical properties. The synthetic route is as follows. category: pyrimidines

To a stirred solution of (COC1)2 (7.33 wL, 84.11 mmol) in anhydrous (CH2C1)2(20 mL) at 0C under nitrogen was added DMF (4.47 mL, 57.18 mmol). After 20 min asolution of thieno[3,2-J|pyrimidin-4(3H)-one (19) (4 g, 26.28 mmol) in anhydrous(CH2C1)2 (5 mL) was added drop wise to the reaction mixture which was stirred for 20 minat 0C, warmed to room temperature over another 20 min, heated at 80C for 1.5 hours, andcooled to room temperature. Finally, the reaction mixture was poured into water andextracted with DCM. The extract was washed sequentially with water, brine, dried over4, filtered and evaporated to afford the title compound 20 (4.36 g, 97% yield) as ayellow solid. .H NMR (400 MHz, DMSO-dfe) §(ppm): 9.02 (s, 1H), 8.59 (d, J = 5.2 Hz,lH),7.75(d,J = 5.2Hz, 1H).

With the rapid development of chemical substances, we look forward to future research findings about 16234-10-9.

Reference:
Patent; METHYLGENE, INC.; WO2006/10264; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 16234-10-9, name is Thieno[3,2-d]pyrimidin-4(3H)-one. This compound has unique chemical properties. The synthetic route is as follows. category: pyrimidines

To a stirred solution of (COC1)2 (7.33 wL, 84.11 mmol) in anhydrous (CH2C1)2(20 mL) at 0C under nitrogen was added DMF (4.47 mL, 57.18 mmol). After 20 min asolution of thieno[3,2-J|pyrimidin-4(3H)-one (19) (4 g, 26.28 mmol) in anhydrous(CH2C1)2 (5 mL) was added drop wise to the reaction mixture which was stirred for 20 minat 0C, warmed to room temperature over another 20 min, heated at 80C for 1.5 hours, andcooled to room temperature. Finally, the reaction mixture was poured into water andextracted with DCM. The extract was washed sequentially with water, brine, dried over4, filtered and evaporated to afford the title compound 20 (4.36 g, 97% yield) as ayellow solid. .H NMR (400 MHz, DMSO-dfe) §(ppm): 9.02 (s, 1H), 8.59 (d, J = 5.2 Hz,lH),7.75(d,J = 5.2Hz, 1H).

With the rapid development of chemical substances, we look forward to future research findings about 16234-10-9.

Reference:
Patent; METHYLGENE, INC.; WO2006/10264; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 16234-10-9 , The common heterocyclic compound, 16234-10-9, name is Thieno[3,2-d]pyrimidin-4(3H)-one, molecular formula is C6H4N2OS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a mixture of H2SO4 (20 mL) and HNO3 (15 mL) was added compound 3 (9.7 g, 0.064 mol) slowly under ice-bath condition. Then, the reaction mixture was heated to room temperature. When the staring material was consumed, the mixture was poured into the ice-water carefully, and the yellow solid was formed, followed by filtration. The cakewas washed with water for three times, dried to afford the desired compound 4, 10.8 g as yellow solid in 86% yield. 1H NMR (400 MHz, DMSO-d6) delta 13.00 (s, 1H), 9.33 (s, 1H), 8.35 (s, 1H); MS (ESI) m/z 195.9 [M+H]+.

The synthetic route of 16234-10-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wang, Jiang; Su, Mingbo; Li, Tingting; Gao, Anhui; Yang, Wei; Sheng, Li; Zang, Yi; Li, Jia; Liu, Hong; European Journal of Medicinal Chemistry; vol. 128; (2017); p. 293 – 299;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 16234-10-9, Adding some certain compound to certain chemical reactions, such as: 16234-10-9, name is Thieno[3,2-d]pyrimidin-4(3H)-one,molecular formula is C6H4N2OS, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16234-10-9.

Thieno[3,2-d]pyrimidin-4(3H)-one (38.0 g, 0.25 mol) was dissolved in acetic acid (143 mL, 2.5 mol), and bromine (40.4 mL, 0.78 mol) diluted with acetic acid (122 mL, 2.1 mol) was slowly added to the solution prepared. The reaction solution was stirred in a sealed reactor for 18 hours at 120C. The reaction solution was cooled to room temperature and acetic acid was removed by distillation under reduced pressure. The reaction mixture was poured into an ice water to generate a solid compound, and the resulting solid compound was filtered and dried. The title compound was obtained without purification (37.5 g, 65%). 1H-NMR Spectrum (300 MHz, DMSO-d6): delta 12.75 (brs, 1H), 8.36 (s, lh), 8.24 (s, 1H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 16234-10-9, Thieno[3,2-d]pyrimidin-4(3H)-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; HANMI PHARM CO., LTD.; BAE, In Hwan; SON, Jung Beom; HAN, Sang Mi; KWAK, Eun Joo; KIM, Ho Seok; SONG, Ji Young; BYUN, Eun Young; JUN, Seung Ah; AHN, Young Gil; SUH, Kwee Hyun; WO2013/100632; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 16234-10-9, Thieno[3,2-d]pyrimidin-4(3H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 16234-10-9, blongs to pyrimidines compound. Safety of Thieno[3,2-d]pyrimidin-4(3H)-one

Thieno[3,2-d]pyrimidin-4(3H)-one (12.5 g) was dissolved in acetic acid (52 mL), and bromine (13 mL) was added thereto. The reaction mixture was stirred at 120 C. for 12 hours in a hermetically sealed reactor. The reaction mixture was cooled to room temperature and distilled under reduced pressure to remove acetic acid. The reaction mixture was placed in ice water, and the solid thus obtained was filtered and washed with ether, and dried to obtain the title compound (7.8 g). [0172] 1H NMR (300 MHz, DMSO-d6): delta 12.75 (brs, 1H), 8.36 (s, 1H), 8.24 (s, 1H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16234-10-9, its application will become more common.

Reference:
Patent; HANMI PHARM. CO., LTD; Son, Jung Beom; Kim, Nam Du; Chang, Young Kil; Kim, Hee Cheol; Kim, Ji Sook; Jung, Young Hee; US2013/274268; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 16234-10-9 ,Some common heterocyclic compound, 16234-10-9, molecular formula is C6H4N2OS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of DMF (13.2 mL, 170 mmol) in DCM (100 mL) at 0C was added oxalyl chloride (22 mL, 252 mmol) in DCM (100 mL) very slowly over 1 hour. To the resulting white gel solution was added the 3H-thieno [3,2-d] pyrimidin-4-one (12 g, 79 mmol). The mixture was refluxed for 4 hours. After cooling, the mixture was purred into water (500 mL) and extracted with DCM (3×250 mL). Then the organic phase was dried over magnesium sulfate, filtered and concentrated to afford 7-chloro-thieno [3,2-b] pyridine as white solid (13.4 g, 99%). 1H NMR (CDCl3, 400 Hz) 8 9.00 (s, 1H), 8.06 (d, J=5.6Hz, 1H), 7.61 (d, J=5.6Hz, 1H). MS (ESI+) [M+H] + 170

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16234-10-9, its application will become more common.

Reference:
Patent; ARRAY BIOPHARMA INC.; WO2005/51304; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 16234-10-9, Thieno[3,2-d]pyrimidin-4(3H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 16234-10-9, blongs to pyrimidines compound. Recommanded Product: 16234-10-9

Thieno[3,2-d]pyrimidine-4(3H)-one (4.9 g) was dissolved in acetic acid (20 mL) and then brome (5 mL) was added thereto. In a sealed reactor, the reaction mixture was stirred at 120 C. for 10 hours. The reaction mixture was cooled to room temperature and distilled under reduced pressure to remove acetic acid. The resulting mixture was added to ice water and the resulting solid was filtered and then dried to obtain the title compound without further purification. 1H NMR (400 MHz, DMSO-d6) delta 12.75 (brs, 1H), 8.36 (s, 1H), 8.24 (s, 1H).

The synthetic route of 16234-10-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; HANMI SCIENCE CO., LTD.; CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION; KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; Son, Jung Beom; Jung, Seung Hyun; Choi, Wha ll; Jung, Young Hee; Choi, Jae Yul; Song, Ji Yeon; Lee, Kyu Hang; Lee, Jae Chul; Kim, Eun Young; Ahn, Young Gil; Kim, Maeng Sup; Choi, Hwan Geun; Sim, Tae Bo; Ham, Young Jin; Park, Dong-sik; Kim, Hwan; Kim, Dong-Wook; US2013/53370; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 16234-10-9, name is Thieno[3,2-d]pyrimidin-4(3H)-one. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 16234-10-9

4-Chlorothieno[3, 2-d]pyrimidine VlTo a solution of 6.12 ml of dimethylformannide in 45 ml of methylene chloride is added dropwise at 25C a solution of 9.95 ml of oxalyl chloride in 45 ml of methylene chloride. Subsequently, 5.5 g of compound Vila are added and then the mixture is heated at reflux for 2.5 hours. The reaction mixture is added cautiously to water and extracted three times with methylene chloride. The combined organic phases are dried over sodium sulphate and, after filtration, concentrated under reduced pressure. After drying under reduced pressure, 4.9 g of compound Vl are obtained as a crude product, which is reacted further without further purification.NMR (300 MHz, DMSO-d6): delta = 7.73 (1 H), 8.57 (1 H), 9.01 (1 H).

With the rapid development of chemical substances, we look forward to future research findings about 16234-10-9.

Reference:
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; WO2009/7421; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia