Application of 16462-28-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16462-28-5, name is 4-Amino-2-hydroxypyrimidine-5-carbonitrile. A new synthetic method of this compound is introduced below.
After the reaction in step (2), the intermediate II obtained is added with 2.5-3.0mol / L of dilute hydrochloric acid 30-150mL, and then the microwave reaction temperature is 80-100 CThe power is 500W, radiate for 30 to 50 minutes under normal pressure, cool, and filter to get:The urea 1-300 mmol and malononitrile 1-300 mmol are carried out in an amount of equal substances and an excess of 10-80 mL of triethyl orthoformate,The microwave temperature does not exceed 80 degrees at 500W power, otherwise it will affect product purity and color.In order to get good products,The intermediate II in the second step is decolorized with 0.1-0.5 g of activated carbon and acidified with 5-30 mL of glacial acetic acid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,16462-28-5, 4-Amino-2-hydroxypyrimidine-5-carbonitrile, and friends who are interested can also refer to it.
Reference:
Patent; Zunyi Medical College; Yuan Zeli; He Shunli; Song Wenting; Yu Guangqin; (6 pag.)CN104356073; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia