Category: 1683-85-8

Related Products of 1683-85-8 , The common heterocyclic compound, 1683-85-8, name is 5-Fluoropyrimidin-2-amine, molecular formula is C4H4FN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A suspension of 5-chloro-2,4-difluorobenzenesulfonyl chloride (1 .99 g, 8.05 mmol) in dichloromethane (15 ml_) was added portion-wise to a solution of 5-fluoro-pyrimidin-2- ylamine (1 .00 g, 8.84 mmol) in pyridine (15 ml_) at 0 C. The reaction mixture was then allowed to warm to ambient temperature gradually and stirred for 1 6 hours. The reaction mixture was diluted with dichloromethane and partitioned with 1 N aqueous hydrogen chloride solution. The layers were separated and the aqueous layer extracted with dichloromethane. The combined organic layers were washed with water, diluted with ethyl acetate, dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue was purified by automated silica gel column chromatography (100% chloroform to 10% methanol in chloroform gradient elution) to afford the title compound as a light yellow solid (0.32 g).1HNMR (de-DMSO): delta 7.85 (m, 1 H), 8.17 (m, 1 H), 8.67 (s, 2H).LCMS Rt = 1 .53 min MS m/z 324 [MH]+

The synthetic route of 1683-85-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER LIMITED; ICAGEN, INC.; MARKWORTH, Christopher John; MARRON, Brian Edward; RAWSON, David James; STORER, Robert Ian; SWAIN, Nigel Alan; WEST, Christopher William; ZHOU, Shulan; WO2012/4706; (2012); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 1683-85-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1683-85-8, name is 5-Fluoropyrimidin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

To a mixture of 5-fluoropyrimidin-2-amine (8.2 g, 72.1 mmol) and sodium hydride (5.8 g, 144 mmol) in THF (100 mL) was added 2,4-dichloro-6-methyl-3-nitropyridine (15 g, 72.1 mmol). After stirring for 10 h, ethanol was added. Silica gel chromatography (5:1Hexane:EtOAc) provided the product as a yellow solid (12.8 g, 63%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1683-85-8, 5-Fluoropyrimidin-2-amine.

Reference:
Patent; Janssen Pharmaceutica NV; Alcazar Vaca, Manuel Jesus; Andres Gil, Jose Ignacio; Chrovian, Christa C.; Coate, Heather R.; De Angelis, Meri; Dvorak, Curt A.; Gelin, Christine F.; Letavic, Michael A.; Savall, Brad M.; Soyode-Johnson, Akinola; Stenne, Brice M.; Swanson, Devin M.; US2014/275015; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia