Category: 16879-39-3

Raoufmoghaddam, Saeed et al. published their research in Chemistry – A European Journal in 2015 | CAS: 16879-39-3

2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Application of 16879-39-3

Palladium(0)/NHC-Catalyzed Reductive Heck Reaction of Enones: A Detailed Mechanistic Study was written by Raoufmoghaddam, Saeed;Mannathan, Subramaniyan;Minnaard, Adriaan J.;de Vries, Johannes G.;Reek, Joost N. H.. And the article was included in Chemistry – A European Journal in 2015.Application of 16879-39-3 This article mentions the following:

We have studied the mechanism of the palladium-catalyzed reductive Heck reaction of para-substituted enones with 4-iodoanisole by using N,N-diisopropylethylamine (DIPEA) as the reductant. Kinetic studies and in situ spectroscopic anal. have provided a detailed insight into the reaction. Progress kinetic anal. demonstrated that neither catalyst decomposition nor product inhibition occurred during the catalysis. The reaction is first order in the palladium and aryl iodide, and zero order in the activated alkene, N-heterocyclic carbene (NHC) ligand, and DIPEA. The experiments with deuterated solvent ([D7]DMF) and deuterated base ([D15]Et3N) supported the role of the amine as a reductant in the reaction. The palladium complex [Pd0(NHC)(1)] has been identified as the resting state. The kinetic experiments by stopped-flow UV/Vis also revealed that the presence of the second substrate, benzylideneacetone 1, slows down the oxidative addition of 4-iodoanisole through its competing coordination to the palladium center. The kinetic and mechanistic studies indicated that the oxidative addition of the aryl iodide is the rate-determining step. Various scenarios for the oxidative addition step have been analyzed by using DFT calculations (bp86/def2-TZVP) that supported the inhibiting effect of substrate 1 by formation of resting state [Pd0(NHC)(1)] species at the cost of further increase in the energy barrier of the oxidative addition step. In the experiment, the researchers used many compounds, for example, 2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3Application of 16879-39-3).

2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Application of 16879-39-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Mikhailov, A. S. et al. published their research in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in 1981 | CAS: 16879-39-3

2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Application of 16879-39-3

Behavior of some 2-(闁?bromoalkylthio)-4,6-dimethylpyrimidines during heating was written by Mikhailov, A. S.;Pashkurov, N. G.;Reznik, V. S.. And the article was included in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in 1981.Application of 16879-39-3 This article mentions the following:

The thermal behavior of I (n = 4, 5, 6) on heating in vacuo to 150-240闁?depended on the value of n; cyclization played a significant role in the reaction patterns only when n = 4. Products found included, e.g., II and thiophane, as well as more complex compounds In the experiment, the researchers used many compounds, for example, 2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3Application of 16879-39-3).

2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Application of 16879-39-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Cai, Chun et al. published their research in Yingyong Huaxue in 2004 | CAS: 16879-39-3

2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Application In Synthesis of 2-Bromo-4,6-dimethylpyrimidine

Solventless synthesis of the 2,2′-bipyrimidine derivatives was written by Cai, Chun;Lue, Chun-Xu. And the article was included in Yingyong Huaxue in 2004.Application In Synthesis of 2-Bromo-4,6-dimethylpyrimidine This article mentions the following:

A non-solvent synthesis procedure for the preparation of 2,2′-bipyrimidine, 4,4′,6,6′-tetramethyl-2,2′-bipyrimidine and 4,4′, 6,6′-tetraphenyl-2,2′-bipyrimidine in high yields was developed using fresh copper powder as catalyst. In the experiment, the researchers used many compounds, for example, 2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3Application In Synthesis of 2-Bromo-4,6-dimethylpyrimidine).

2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Application In Synthesis of 2-Bromo-4,6-dimethylpyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Raoufmoghaddam, Saeed et al. published their research in Chemistry – A European Journal in 2015 | CAS: 16879-39-3

2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Application of 16879-39-3

Palladium(0)/NHC-Catalyzed Reductive Heck Reaction of Enones: A Detailed Mechanistic Study was written by Raoufmoghaddam, Saeed;Mannathan, Subramaniyan;Minnaard, Adriaan J.;de Vries, Johannes G.;Reek, Joost N. H.. And the article was included in Chemistry – A European Journal in 2015.Application of 16879-39-3 This article mentions the following:

We have studied the mechanism of the palladium-catalyzed reductive Heck reaction of para-substituted enones with 4-iodoanisole by using N,N-diisopropylethylamine (DIPEA) as the reductant. Kinetic studies and in situ spectroscopic anal. have provided a detailed insight into the reaction. Progress kinetic anal. demonstrated that neither catalyst decomposition nor product inhibition occurred during the catalysis. The reaction is first order in the palladium and aryl iodide, and zero order in the activated alkene, N-heterocyclic carbene (NHC) ligand, and DIPEA. The experiments with deuterated solvent ([D7]DMF) and deuterated base ([D15]Et3N) supported the role of the amine as a reductant in the reaction. The palladium complex [Pd0(NHC)(1)] has been identified as the resting state. The kinetic experiments by stopped-flow UV/Vis also revealed that the presence of the second substrate, benzylideneacetone 1, slows down the oxidative addition of 4-iodoanisole through its competing coordination to the palladium center. The kinetic and mechanistic studies indicated that the oxidative addition of the aryl iodide is the rate-determining step. Various scenarios for the oxidative addition step have been analyzed by using DFT calculations (bp86/def2-TZVP) that supported the inhibiting effect of substrate 1 by formation of resting state [Pd0(NHC)(1)] species at the cost of further increase in the energy barrier of the oxidative addition step. In the experiment, the researchers used many compounds, for example, 2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3Application of 16879-39-3).

2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Application of 16879-39-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Mikhailov, A. S. et al. published their research in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in 1981 | CAS: 16879-39-3

2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Application of 16879-39-3

Behavior of some 2-(ω-bromoalkylthio)-4,6-dimethylpyrimidines during heating was written by Mikhailov, A. S.;Pashkurov, N. G.;Reznik, V. S.. And the article was included in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in 1981.Application of 16879-39-3 This article mentions the following:

The thermal behavior of I (n = 4, 5, 6) on heating in vacuo to 150-240° depended on the value of n; cyclization played a significant role in the reaction patterns only when n = 4. Products found included, e.g., II and thiophane, as well as more complex compounds In the experiment, the researchers used many compounds, for example, 2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3Application of 16879-39-3).

2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Application of 16879-39-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Stasi, Luigi Piero et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2013 | CAS: 16879-39-3

2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Reference of 16879-39-3

Discovery, synthesis, selectivity modulation and DMPK characterization of 5-azaspiro[2.4]heptanes as potent orexin receptor antagonists was written by Stasi, Luigi Piero;Artusi, Roberto;Bovino, Clara;Buzzi, Benedetta;Canciani, Luca;Caselli, Gianfranco;Colace, Fabrizio;Garofalo, Paolo;Giambuzzi, Silvia;Larger, Patrice;Letari, Ornella;Mandelli, Stefano;Perugini, Lorenzo;Pucci, Sabrina;Salvi, Matteo;Toro, PierLuigi. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.Reference of 16879-39-3 This article mentions the following:

Starting from an orexin 1 receptor selective antagonist 4,4-disubstituted piperidine series, a novel potent 5-azaspiro[2.4]heptane dual orexin 1 and orexin 2 receptor antagonist class has been discovered. SAR and pharmacokinetic optimization of this series is herein disclosed. Lead compound I exhibits potent activity against orexin 1 and orexin 2 receptors along with low cytochrome P 450 inhibition potential, good brain penetration and oral bioavailability in rats. In the experiment, the researchers used many compounds, for example, 2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3Reference of 16879-39-3).

2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Reference of 16879-39-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Yamanaka, Hiroshi et al. published their research in Chemical & Pharmaceutical Bulletin in 1985 | CAS: 16879-39-3

2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Recommanded Product: 2-Bromo-4,6-dimethylpyrimidine

Studies of pyrimidine derivatives. XXXVIII. Cross-coupling reaction of N-heteroaryl iodides with ethoxycarbonylmethylzinc bromide in the presence of palladium catalyst was written by Yamanaka, Hiroshi;Annaka, Masayuki;Kondo, Yoshinori;Sakamoto, Takao. And the article was included in Chemical & Pharmaceutical Bulletin in 1985.Recommanded Product: 2-Bromo-4,6-dimethylpyrimidine This article mentions the following:

In the presence of tetrakis(triphenylphosphine)palladium, 2-iodo-4,6-dimethylpyrimidine and 4-iodo-2,6-dimethylpyrimidine reacted with ethoxycarbonylmethylzinc bromide (Reformatskii reagent) to give Et 4,6-dimethyl-2-pyrimidineacetate and Et 2,6-dimethyl-4-pyrimidineacetate, resp. In contrast, the reaction of 5-iodo-2,4-dimethylpyrimidine with the same reagent resulted in recovery of the starting iodide. Similar results were observed in the reactions of various N-heteroaryl iodides. In the experiment, the researchers used many compounds, for example, 2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3Recommanded Product: 2-Bromo-4,6-dimethylpyrimidine).

2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Recommanded Product: 2-Bromo-4,6-dimethylpyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Stasi, Luigi Piero et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2013 | CAS: 16879-39-3

2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Reference of 16879-39-3

Discovery, synthesis, selectivity modulation and DMPK characterization of 5-azaspiro[2.4]heptanes as potent orexin receptor antagonists was written by Stasi, Luigi Piero;Artusi, Roberto;Bovino, Clara;Buzzi, Benedetta;Canciani, Luca;Caselli, Gianfranco;Colace, Fabrizio;Garofalo, Paolo;Giambuzzi, Silvia;Larger, Patrice;Letari, Ornella;Mandelli, Stefano;Perugini, Lorenzo;Pucci, Sabrina;Salvi, Matteo;Toro, PierLuigi. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.Reference of 16879-39-3 This article mentions the following:

Starting from an orexin 1 receptor selective antagonist 4,4-disubstituted piperidine series, a novel potent 5-azaspiro[2.4]heptane dual orexin 1 and orexin 2 receptor antagonist class has been discovered. SAR and pharmacokinetic optimization of this series is herein disclosed. Lead compound I exhibits potent activity against orexin 1 and orexin 2 receptors along with low cytochrome P 450 inhibition potential, good brain penetration and oral bioavailability in rats. In the experiment, the researchers used many compounds, for example, 2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3Reference of 16879-39-3).

2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Reference of 16879-39-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Yamanaka, Hiroshi et al. published their research in Chemical & Pharmaceutical Bulletin in 1985 | CAS: 16879-39-3

2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Recommanded Product: 2-Bromo-4,6-dimethylpyrimidine

Studies of pyrimidine derivatives. XXXVIII. Cross-coupling reaction of N-heteroaryl iodides with ethoxycarbonylmethylzinc bromide in the presence of palladium catalyst was written by Yamanaka, Hiroshi;Annaka, Masayuki;Kondo, Yoshinori;Sakamoto, Takao. And the article was included in Chemical & Pharmaceutical Bulletin in 1985.Recommanded Product: 2-Bromo-4,6-dimethylpyrimidine This article mentions the following:

In the presence of tetrakis(triphenylphosphine)palladium, 2-iodo-4,6-dimethylpyrimidine and 4-iodo-2,6-dimethylpyrimidine reacted with ethoxycarbonylmethylzinc bromide (Reformatskii reagent) to give Et 4,6-dimethyl-2-pyrimidineacetate and Et 2,6-dimethyl-4-pyrimidineacetate, resp. In contrast, the reaction of 5-iodo-2,4-dimethylpyrimidine with the same reagent resulted in recovery of the starting iodide. Similar results were observed in the reactions of various N-heteroaryl iodides. In the experiment, the researchers used many compounds, for example, 2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3Recommanded Product: 2-Bromo-4,6-dimethylpyrimidine).

2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Recommanded Product: 2-Bromo-4,6-dimethylpyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

A new synthetic route of 2-Bromo-4,6-dimethylpyrimidine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16879-39-3, its application will become more common.

Synthetic Route of 16879-39-3 ,Some common heterocyclic compound, 16879-39-3, molecular formula is C6H7BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Copper (I) iodide (1.013 mg, 5.32 muetaiotaomicron) was added to a mixture of 2- chloropyridine 99% (6.50 mu, 0.069 mmol), N-(4-fluoro-5-(l,2,3,6-tetrahydropyridin- 4-yl)-2-((3S,5R)-3,4,54rimethylpiperazin-1-yl)phenyl)-6-oxo-4-(trifluoromethyl)-l,6- dihydropyridine-3-carboxamide (27 mg, 0.053 mmol) and N,N-diisopropylethylamine (0.028 ml, 0.160 mmol) in ethylene glycol (1.5 ml). The mixture was heated in a microwave reactor at 180 C for lh. The mixture was quenched and worked up in a similar manner to Example 148 to provide the title compound as a yellow powder (8.5 mg, 26 %). 11H NMR (500MHz, METHANOL-d4) delta = 7.99 (dd, J=1.2, 4.9 Hz, 1H), 7.85 – 7.82 (m, 1H), 7.73 – 7.67 (m, 1H), 7.51 – 7.45 (m, 1H), 6.87 – 6.83 (m, 1H), 6.82 – 6.79 (m, 1H), 6.76 – 6.71 (m, 1H), 6.60 – 6.52 (m, 1H), 6.08 – 6.01 (m, 1H), 4.04 – 3.99 (m, 2H), 3.75 – 3.70 (m, 2H), 2.95 – 2.90 (m, 2H), 2.55 – 2.43 (m, 6H), 2.29 – 2.27 (m, 3H), 1.06 (d, J=5.9 Hz, 6H); LCMS [M+H]+ 585.5. A procedure similar to that of Example 270 using N-(4-fluoro-5-(l, 2,3,6- tetrahydropyridin-4-yl)-2-((3S,5R)-3,4,5-trimethylpiperazin-l-yl)phenyl)-6-oxo-4- (trifluoromethyl)-l,6-dihydropyridine-3-carboxarnide (30 mg, 0.059 mmol) and 2-bromo- 4,6-dimethylpyrimidine (13.27 mg, 0.071 mmol) gave the title compound (28 mg, 73 % yield). NMR (500MHz, METHANOL-d4) delta = 7.99 – 7.92 (m, 1H), 7.83 – 7.75 (m, 1H), 6.98 – 6.94 (m, 1H), 6.93 – 6.90 (m, 1H), 6.46 – 6.39 (m, 1H),6.16 – 6.08 (m, 1H), 4.41 – 4.37 (m, 2H), 4.09 – 4.03 (m, 2H), 3.07 – 3.00 (m, 2H), 2.63 – 2.52 (m, 6H), 2.39 – 2.37 (m, 3H), 2.33 – 2.30 (m, 6H), 1.17(d, J=6.0 Hz, 6H); LCMS [M+H]+ 614.7.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16879-39-3, its application will become more common.

Reference:
Patent; ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR); AL-AWAR, Rima; ZEPEDA-VELAZQUEZ, Carlos Armando; PODA, Gennady; ISAAC, Methvin; UEHLING, David; WILSON, Brian; JOSEPH, Babu; LIU, Yong; SUBRAMANIAN, Pandiaraju; MAMAI, Ahmed; PRAKESCH, Michael; STILLE, Julia Kathleen; (1053 pag.)WO2017/147700; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia