Category: 171178-33-9

Reference of 171178-33-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 171178-33-9, name is 6-Chloropyrido[3,2-d]pyrimidin-4(3H)-one. This compound has unique chemical properties. The synthetic route is as follows.

6-Chloro-3/7-pyrido[3,2-i/]pyrimidin-4-onc (1.242 g, 6.67 mmol), tert- butyl l-oxa-6- azaspiro[2.5]octane-6-carboxylate (2.34 g, 11 mmol) and K2CO3 (2.76 g, 19.9 mmol) were stirred in DMF (20 ml) at 70 C for 48 hours. The reaction mixture was filtered, and the resulted filtrate was purified by preparative LC (on C-18 Gemini-NX 5 pm column, 5 mM aqueous NH4HC03-MeCN, gradient), to give tert- butyl 4-[(6-chloro-4-oxo-quinazolin-3- yl)methyl]-4-hydroxy-piperidine- 1 -carboxylate.

According to the analysis of related databases, 171178-33-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; LES LABORATOIRES SERVIER; VERNALIS (R&D) LIMITED; KOTSCHY, Andras; WEBER, Csaba; VASAS, Attila; KISS, Arpad; MOLNAR, Balazs; STROFEK, Agnes; KUN, Vilibald; MURRAY, James Brooke; MACIAS, Alba; LEWKOWICZ, Elodie; CHANRION, Maia; IVANSCHITZ, Lisa; GENESTE, Olivier; (86 pag.)WO2019/105963; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 171178-33-9, 6-Chloropyrido[3,2-d]pyrimidin-4(3H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 6-Chloropyrido[3,2-d]pyrimidin-4(3H)-one, blongs to pyrimidines compound. Application In Synthesis of 6-Chloropyrido[3,2-d]pyrimidin-4(3H)-one

Method A: To a solution of 6-chloro-pyrido[3,2-d]pyrimidin-4(3H)-one (200 mg,1.1 mmol) in 1 ,4-dioxane (20 ml) and water (10 ml) was added 3,4-dimethoxyphenyl boronic acid (240 mg, 1.32 mmol), potassium carbonate (380 mg, 2.75 mmol) and tetrakis(triphenylphosphine)palladium(0) (63 mg, 0.055 mmol). The reaction mixture was refluxed for 3 hours, cooled down to room temperature and the solvents were evaporated in vacuo. The residue was adsorbed on silica, purified by silica gel column chromatography (the mobile phase being a acetone/dichloromethane mixture, in a ratio gradually ranging from 30:70 to 40:60) and characterised by its mass spectrum as follows : MS (m/z) : 284 ([M+H]+, 100).Method B: A suspension of 2-carboxamido-3-amino-6-(3,4-dimethoxyphenyl)- pyridine (770 mg, 2.8 mmol) in triethyl orthoformate (28 ml) was refluxed for 12 hours. Then, the reaction mixture was cooled down and evaporated to dryness. The residue was purified by silica gel column chromatography (the mobile phase being an ethyl acetate/hexane mixture in a ratio gradually ranging from 2:8 to 3:7), resulting in the pure title compound (530 mg, yield 67 %) which was characterised by its mass spectrum as follows: MS (m/z) : 284 ([M+H)+, 100].

The synthetic route of 171178-33-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; 4 AZA Bioscience nv; WO2006/135993; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia