Category: 17321-97-0

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 17321-97-0, name is 2-Amino-4-methylpyrimidine-5-carbonitrile. A new synthetic method of this compound is introduced below., Computed Properties of C6H6N4

To a stirred solution of intermediate 41B (500 g, 3730 mmol) in TI-IF (75 mL) andDMF (15 rnL) was added copper (II) bromide (16.65 g, 74.50 rnmol) and Isoamyl nitrite (7.53ml, 55,9 mmol) and the reaction was refluxed for I h. The reaction mixture was cooled to ambient temperature, concentrated to dryness, diluted with the DCM (200 mL), filtered, and washed with THF (200 ml.). The combined organic extracts were washed with 10 % Nai-1C03 (150 mL). Then brine (50 mL), dried over anhydrous sodium sulfate and evaporated underreduced pressure. The residue was puiified by column chromatography (Redisep.-120 g, 0-15 % EtOAc/n.-I-Iexane) to obtain intermediate 41C (0.75 g, 10.00%). ?H NMR (400 MHz, DMSO d6) S ppm 2.65 (s. 3 1-1), 908 (s, 1 H). LCMS MethodL); retention time 0.92 mm, [M±2H1199.1.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 17321-97-0, 2-Amino-4-methylpyrimidine-5-carbonitrile.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; GUNAGA, Prashantha; BHIDE, Rajeev S.; BORA, Rajesh Onkardas; PANDA, Manoranjan; YADAV, Navnath Dnyanoba; PRIESTLEY, Eldon Scott; RICHTER, Jeremy; (321 pag.)WO2018/93569; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 17321-97-0, 2-Amino-4-methylpyrimidine-5-carbonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 17321-97-0, blongs to pyrimidines compound. COA of Formula: C6H6N4

General procedure: To the solution of corresponding quinazolone intermediate 13a(13b, 13c or 13d) in DCM (4 mL/1 mmol substrate)was added TFA (1mL/1 mmol substrate) dropwise at 0 C, and the resultant mixturewas stirred at room temperature. After 13a (13b, 13c or 13d) wastotally consumed, saturated NaHCO3 solution was added dropwiseat 0 C to adjust the PH value to 7. Following extraction with DCM,the organic layer was washed with brine, dried over anhydrousNa2SO4, and concentrated in vacuo to afford the Boc-deprotectedsecondary amine as slightly yellow solid.The mixture of corresponding Boc-deprotected secondaryamine (1.0 eq), 6-chloro-9H-purine (1.5 eq), DIPEA (4.0 eq) and t-BuOH (15 mL/1 mmol secondary amine) was stirred at 80 C underN2 atmosphere. After the secondary aminewas totally consumed, t-BuOH was removed in vacuo, and the residue was dissolved inDCM. The solution was washed with saturated NaHCO3 solution,dried over anhydrous Na2SO4, and concentrated in vacuo. Finally,the crude product underwent flash column chromatography (DCM/EA 5:1-1:1, V/V) to afford the purine derivative (14 or 15e17) aspale solid. Compounds with 4-aminopyrimidine-5-carbonitrile, 2-amino-6-methylpyrimidine-5-carbonitrile, 2-fluoro-9H-purine or2-chloro-9H-purine as HBs were prepared via similar procedure tothat for 14e17. However, the eluents utilized in the final flash columnchromatography of 21, 22, 24, 25 and 27 were different (DCM/EA 15:1-5:1, V/V, for 21, 24 and 27; DCM/EA 20:1-8:1, V/V, for22 and 25). The NMR spectra of 14e17, 28 and 29 indicated theexistence of rotamers.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,17321-97-0, its application will become more common.

Reference:
Article; Chen, Yuqing; Fang, Fang; Gui, Shuangying; Hu, Yongzhou; Li, Jiaming; Liang, Jingtai; Liang, Xiao; Ma, Xiaodong; Meng, Chang; Tao, Qiangqiang; Wang, Huchuan; European Journal of Medicinal Chemistry; vol. 191; (2020);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia