Category: 17573-78-3

Synthetic Route of 17573-78-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.17573-78-3, name is 4,5,6-Trifluoropyrimidine, molecular formula is C4HF3N2, molecular weight is 134.06, as common compound, the synthetic route is as follows.

Example (IV-1) Process e) 2.52 g (0.01 mol) of (5,6-dihydro-[1,4,2]oxathiazin-3-yl)-(2-hydroxyphenyl)-methanone O-methyloxime are dissolved in 10 ml of acetonitrile and admixed with 1.7 g (0.0123 mol) of potassium carbonate. The mixture is then cooled with stirring to 0 C., and 1.34 g (0.01 mol) of 4,5,6-trifluoropyrimidine are then added. Without further cooling, the mixture is stirred for another 12 hours. The solvent is then distilled off under reduced pressure and the residue is poured into water and extracted with ethyl acetate. The organic phase is dried over sodium sulphate and the solvent is distilled off under reduced pressure. This gives 2.3 g (62% of theory) of [2-(5,6-difluoro-pyrimidine-4-yloxy)-phenyl]-(5,6-dihydro-[1,4,2]oxathiazin-3-yl)-methanone O-methyloxime. 1H NMR spectrum (CDCl3/TMS): delta=3.15/3.16/3.17/3.18 (2H); 3.83 (3H); 4.11/4.12/4.13/4.14 (2H); 7.26-7.53 (4H); 8.20 (1H) ppm.

The chemical industry reduces the impact on the environment during synthesis 17573-78-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Bayer Aktiengesellschaft; US6407097; (2002); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17573-78-3, name is 4,5,6-Trifluoropyrimidine, the common compound, a new synthetic route is introduced below. category: pyrimidines

[00339] 11.38 g (0.085 mol) of trifluoropyrimidine are dissolved in 240 ml of acetonitrile and admixed with 15.26 g (0.11 mol) of potassium carbonate, and the mixture is cooled to 10 C. Under argon, a solution of 9.52 g (0.085 mol) of 3-fluorophenol in 80 ml of acetonitrile is added dropwise. The mixture is then stirred under argon, without further cooling, for another 18 hours. The mixture is poured into 1 litre of water and extracted three times with in each case 150 ml of ethyl acetate, and the organic phase is dried over sodium sulphate and concentrated under reduced pressure. The residue is subjected to kugelrohr distillation. This gives 15.2 g (79.1% of theory) of 5,6-difluoro-(3-fluorophenoxy)-pyrimidine of boiling point 95 C. at 0.5 mbar.

The synthetic route of 17573-78-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bayer Aktiengesellschaft; US6683029; (2004); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 17573-78-3, name is 4,5,6-Trifluoropyrimidine. A new synthetic method of this compound is introduced below., name: 4,5,6-Trifluoropyrimidine

Example 1-3; 0.5 g of 4,5,6-trifluoropyrimidine, 0.38 g of 2-pentyn-l-ol and 0.62 ml of triethylamine were added to 1 ml EPO of toluene, then the mixture was stirred at room temperature for 1 hour. Then the reaction mixture was subjected to silica gel column chromatography to obtain 0.53 g of 4,5-difluoro-6-(2-pentynyloxy)pyrimidine. 1H-NMR: 1.15(t,3H), 2.26(qt,2H), 5. ll(t,2H) , 8.26(s,lH)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 17573-78-3, 4,5,6-Trifluoropyrimidine.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2006/51891; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 17573-78-3, 4,5,6-Trifluoropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines

0.5 gof 4,5, 6-trifluoropyrimidine, 0.31 gof 2-butyn-l-ol and 0.62 ml of N,N-diisopropylethylamine were added to 1 ml of hexane, then the mixture was stirred at room temperature for1 hour. Then the reaction mixture was subjected to silica gel column chromatography to obtain 0.55 g of4-(2-butynyloxy) -5,6-difluoropyrimidine

The synthetic route of 17573-78-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2006/51891; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 17573-78-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.17573-78-3, name is 4,5,6-Trifluoropyrimidine, molecular formula is C4HF3N2, molecular weight is 134.06, as common compound, the synthetic route is as follows.

To a mixture obtained by adding 110.0 g of 4,5,6-trifluoropyrimidine, 114.6 g of potassium carbonate and 16.6 g of triethylamine to 220.0 g of toluene, 60.4 g of 2-butyn-1-o1 was added dropwise at 25 to 30C over one hour, followed by stirring at 30C for 8 hours. Then, 220.0 g of water was added dropwise in the reaction mixture, followed by stirring for 14 hours. Then, 97.5 g of 3,5-dimethylpiperidine (a mixture of a cis-isomer and a trans-isomer in a mixing ratio of about 7 : 3) was added dropwise and, after the mixture was stirred at 30C for 6 hours, the reaction mixture was allowed to stand. After separating into the organic layer and the aqueous layer, the aqueous layer was removed and the organic layer was then washed once with 220.0 g of 5% hydrochloric acid and then washed once with 220.0 g of water. The organic layer was concentrated to obtain 213.8 g (yield: 94%) of 4-(2-butynyloxy)-5-fluoro-6-(3,5-dimethylpiperidino)pyrimid ine (hereinafter referred to as the present compound (3)). Product purity 96% (HPLC)

The chemical industry reduces the impact on the environment during synthesis 17573-78-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Sumitomo Chemical Company, Limited; EP2011795; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17573-78-3, name is 4,5,6-Trifluoropyrimidine, the common compound, a new synthetic route is introduced below. category: pyrimidines

EXAMPLE 2 STR11 3.6 g (0.12 mol) of sodium hydride (80% in paraffin oil) are added in portions at 0 C. to a mixture of 16.1 g (0.12 mol) of 4,5,6-trifluoropyrimidine and 25.2 g (0.12 mol) of methyl 2-(2-hydroxyphenyl)-3-methoxy-acrylate in 120 ml of dimethylformamide, the batch is allowed to come to room temperature, and stirring is then continued for 2 hours. The reaction mixture is then poured into water and extracted using ethyl acetate, and the extract is concentrated in vacuo. The residue is chromatographed on silica gel (eluent: diethyl ether/petroleum ether 1:1). 3.6 g (9.6% of theory) of methyl 2-[2-(5,6-difluoro-4-pyrimidinyloxy)-phenyl]-3-methyloxy-acrylate of melting point 69 C. are obtained.

The synthetic route of 17573-78-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bayer Aktiengesellschaft; US5773445; (1998); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 17573-78-3, 4,5,6-Trifluoropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 17573-78-3, blongs to pyrimidines compound. Formula: C4HF3N2

Example 1 To a mixture obtained by adding 110.0 g of 4,5,6-trifluoropyrimidine, 114.6 g of potassium carbonate and 16.6 g of triethylamine to 220.0 g of toluene, 60.4 g of 2-butyn-1-ol is added dropwise at 25 to 30C over one hour, followed by stirring at 30C. Then, 220.0 g of water is added dropwise into the reaction mixture, followed by stirring. Then, 85.4 g of 3, 3-dimethylpyrrolidine is added dropwise and, after the mixture is stirred at 30C, the reaction mixture is allowed to stand. After separating into the organic layer and the aqueous layer, the aqueous layer is removed and the organic layer is washed once with 220.0 g of 5% hydrochloric acid and then washed once with 220.0 g of water. The organic layer is concentrated to obtain 4-(2-butynyloxy)-5-fluoro-6-(3,3-dimethylpyrrolidin-1-yl)py rimidine (hereinafter referred to as the present compound (1)).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,17573-78-3, its application will become more common.

Reference:
Patent; Sumitomo Chemical Company, Limited; EP2011795; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 17573-78-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.17573-78-3, name is 4,5,6-Trifluoropyrimidine, molecular formula is C4HF3N2, molecular weight is 134.06, as common compound, the synthetic route is as follows.

STR108 A solution of 42.4 g (0.45 mol) of phenol and 50.4 g (0.45 mol) of potassium tert-butoxide in 400 ml of tetrahydrofuran is added dropwise at 0 C. to a solution of 80 g (0.6 mol) of 4,5,6-trifluoropyrimidine in 1 l of tetrahydrofuran. When the addition was complete, the reaction mixture was stirred for 30 minutes at 0 C. and then poured into water and extracted using ethyl acetate. The organic phase is dried over sodium sulphate and concentrated in vacuo, and the residue is stirred with low-boiling petroleum ether. 63.8 g (68.1% of theory) of 4-phenoxy-5,6-difluoropyrimidine of melting point 65-66 C. are obtained.

Statistics shows that 17573-78-3 is playing an increasingly important role. we look forward to future research findings about 4,5,6-Trifluoropyrimidine.

Reference:
Patent; Bayer Aktiengesellschaft; US6103717; (2000); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia