Adding a certain compound to certain chemical reactions, such as: 17758-11-1, 5-Bromo-2-ethoxypyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 17758-11-1, blongs to pyrimidines compound. SDS of cas: 17758-11-1
46B. methyl 3-(4-bromo-3-((2-ethoxypyrimidin-5-yl) amino) phenyl) pentanoate (Absolute Stereochemistry not Determined) To a stirred solution of 46A Enantiomer 1 (2 g, 6.98 mmol), 5-bromo-2-ethoxypyrimidine (1.844 g, 9.08 mmol), Xantphos (0.606 mg, 1.048 mmol) and Cs2CO3 (6.84 g, 20.96 mmol) in 1,4-Dioxane (30 mL), argon gas was bubbled for 5 min. Then Bis(dibenzylideneacetone)palladium (0.200 g, 0.35 mmol) was added and argon gas was bubbled for another 5 min. The reaction mixture was heated at 110 C. for 16 h in a sealed tube. Then the reaction mixture was cooled to room temperature and evaporated under reduced pressure to afford a residue. The residue was reconstituted in a mixture of ethyl acetate (100 mL) and water (50 mL). The organic layer was separated and aqueous layer was extracted with ethyl acetate (2*100 mL). The combined organic layer was washed with water (50 mL), brine (50 mL), dried over anhydrous sodium sulfate, filtered and evaporated under reduced pressure to give the crude material, which was purified via flash silica gel column chromatography to afford 46B (yellow oil, 2 g, 4.60 mmol, 65.9% yield). LC-MS Anal. Calc’d for C18H22BrN3O3, 407.084 found [M+3]410.2, Tr=2.240 min (Method BB).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,17758-11-1, 5-Bromo-2-ethoxypyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; Balog, James Aaron; Seitz, Steven P.; Nara, Susheel Jethanand; Roy, Saumya; Thangathirupathy, Srinivasan; Thangavel, Soodamani; Sistla, Ramesh Kumar; US2020/69646; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia