Category: 1780-26-3

Electric Literature of 1780-26-3 ,Some common heterocyclic compound, 1780-26-3, molecular formula is C5H4Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound 32a is prepared according to the procedure described in US/2006/0004067A1 (Bang-Chi Chen, et al, published Jan. 05, 2006).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1780-26-3, its application will become more common.

Reference:
Patent; Bristol-Myers Squibb Company; US2007/219370; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1780-26-3, Adding some certain compound to certain chemical reactions, such as: 1780-26-3, name is 2-Methyl-4,6-dichloropyrimidine,molecular formula is C5H4Cl2N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1780-26-3.

16.2 g (100 mmol) of 4,6-dichloro-2-methylpyrimidine was added to a solution of 21 g (300 mmol) of hydroxylamine hydrochloride in ethanol (100 ml), and then 30.6 g of triethylamine was added, and the mixture was refluxed at 110 C for 1.5 h. Cool to room temperature, concentrate, wash with water, filter,Drying to obtain 14.3 g of N-(6-chloro-2-methylpyrimidin-4-yl)hydroxylamine (Compound 3),The yield was 90% and the HPLC purity was 99.61%.

According to the analysis of related databases, 1780-26-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ANQING QICHUANG PHARMACEUTICAL CO LTD; Anqing Qichuang Pharmaceutical Co., Ltd.; WU XUEPING; Wu Xueping; SHI ZHUYONG; Shi Zhuyong; (10 pag.)CN108299417; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 1780-26-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1780-26-3, name is 2-Methyl-4,6-dichloropyrimidine, molecular formula is C5H4Cl2N2, molecular weight is 163.0047, as common compound, the synthetic route is as follows.

A mixture of 4,6-dichloro-2-methylpyrimidine (162 mg, 1 mmol) and 1-(2-ethanol)-ylpiperazine (260 mg, 2 mmol) was stirred in dichloromethane (40 mL) at room temperature overnight. After the nucleophilic substitution reaction, after TLC monitoring the reaction, The product 1c (218mg) was isolated through a silica gel column, a white solid, melting point: 72 C, The yield was 85% and the purity was 95%.

The chemical industry reduces the impact on the environment during synthesis 1780-26-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Guangdong University of Technology; Chen Huixiong; Yan Longjia; Li Yongliang; Deng Minggao; Chen Anchao; (25 pag.)CN110483493; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1780-26-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1780-26-3, name is 2-Methyl-4,6-dichloropyrimidine, molecular formula is C5H4Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Compound 32a is prepared according to the procedure described in US/2006/0004067A1 (Bang-Chi Chen, et al, published Jan. 05, 2006).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1780-26-3, 2-Methyl-4,6-dichloropyrimidine.

Reference:
Patent; Bristol-Myers Squibb Company; US2007/219370; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1780-26-3, name is 2-Methyl-4,6-dichloropyrimidine. A new synthetic method of this compound is introduced below., Safety of 2-Methyl-4,6-dichloropyrimidine

At room temperature,1.50 kg of 2-amino-N-(2-chloro-6-methylphenyl)-5-thiazolamide,1.11kg of 4,6-dichloro-2-methylpyrimidine was added to a 50L reactor.Add 13.35kg of tetrahydrofuran,Nitrogen protection, stirring and cooling to -5 C ~ 10 C,The temperature of the reaction solution is maintained at -5C to 10C, and sodium tert-butoxide solids are added to the reaction solution in several portions.The total amount of tert-butoxide sodium solids is 2.13kg, and the addition method is to feed once every 20-30min.Each time no more than 10% of the total and no more than 200g,After the addition, the reaction liquid is allowed to react at -5C to 10C for 1 to 2 hours.After warming the reaction solution to 10 C ~ 30 C,Stir the reaction solution,To HPLC detection of 2-amino-N-(2-chloro-6-methylphenyl)-5-thiazoleamide/N-(2-chloro-6-methylphenyl)-2-[(6-chloro- The amount of 2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide is less than 1.5%.Cool the reaction solution to -10C to 10C.Dropping hydrochloric acid at a concentration of 4 mol/L,Adjust the system pH to 6 to 7,After dropping, continue stirring at -10C10C for 12h,filter,The filter cake is washed with an appropriate amount of water and methanol.The filter cake is vacuum dried at 50-60C.N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide 1.364kg, yield 74.06%;

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1780-26-3, 2-Methyl-4,6-dichloropyrimidine.

Reference:
Patent; Huarun Shuang He Limin Pharmaceutical (Jinan) Co., Ltd.; Qin Yunpeng; Jiang Yang; Gao Hongxu; (12 pag.)CN107089976; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 1780-26-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1780-26-3, name is 2-Methyl-4,6-dichloropyrimidine, molecular formula is C5H4Cl2N2, molecular weight is 163.0047, as common compound, the synthetic route is as follows.

Example 127. 2-[4-(6-Chloro-2-methvl-pyrimidin-4-vl)-piperaziii-l-vll-ethano?71); [0307] To a solution of 4,6-dichloro-2-methyl-pyrimidine (5.0 g, 31 mmol) and 2- pirhoerazin-1-yl-ethanol (2.7 g, 21 mmol) in dioxane (25 mL) was added DEPEA (3.0 mL, 17 mmol). The mixture was heated at reflux for 16 h. The mixture was allowed to cool to room temperature and poured into water. The resulting aqueous layer was extracted with EtOAc and the combined organic layers washed with brine, dried over Na2SO4 and filtered. The filtrate was concentrated and the residue purified by flash chromatography on silica gel (5-10% MeOH/DCM) to afford the title compound as a brown liquid (2.1 g, 39%). MS (ES+): m/z 257 (M+H)+.

Statistics shows that 1780-26-3 is playing an increasingly important role. we look forward to future research findings about 2-Methyl-4,6-dichloropyrimidine.

Reference:
Patent; TARGEGEN, INC.; WO2006/101977; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1780-26-3, Adding some certain compound to certain chemical reactions, such as: 1780-26-3, name is 2-Methyl-4,6-dichloropyrimidine,molecular formula is C5H4Cl2N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1780-26-3.

A suspension of compound 16 (4.0 g, 23.2 mmol) and Cs2CO3 (15.14 g, 46.5 mmol) in 116 ml DMF were stirred at 0 C, compound 12 (5.68 g, 34.8 mmol) were added to the mixture in portion. The reaction mixture was stirred at 0 for 5 min , then stirred at room temperature for 8 h. The suspension was poured into 580 ml ice-water and fiercely stirred about 30 min to give a precipitate. The precipitate was ltered and washed with water and ethyl acetate, then dried under vacuum to aord the desired compound 17 (5.67 g, 82%) as a light yellow solid. 1H-NMR (400 MHz, DMSO-d6): delta 12.38 (s, 1H), 8.15 (s, 1H), 6.95 (s ,1H), 4.30 (q, J = 7.2 HZ, 2H), 2.60 (s, 3H), 1.30 (t, J = 7.2 HZ, 3H).

According to the analysis of related databases, 1780-26-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Li, Hui-ying; He, Ding-Di; Zhao, Xiu-Juan; Sun, Tong-Yan; Zhang, Quan; Bai, Cui-Gai; Chen, Yue; Bioorganic and Medicinal Chemistry Letters; vol. 28; 4; (2018); p. 700 – 706;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1780-26-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1780-26-3, name is 2-Methyl-4,6-dichloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

I) Synthesis of N-(6-chloro-2-methylpyrimidin-4-yl)thiazol-2-amine To a cool (0 C.), stirring suspension of 2-aminothiazole (3.05 g, 0.0305 mol), 4,6-dichloro-2-methylpyrimidine (5.84 g, 0.0358 mol) in THF (50 mL) was added dropwise over 10 minutes via addition funnel a solution of t-BuOK (40 mL, 30% wt in THF, 0.1069 mol). The reaction was allowed to slowly warm to room temperature overnight. To the reaction was added water (40 mL) and the resulting clear solution was extracted with chloroform and then chloroform/methanol (4:1). The combined extracts were concentrated to near dryness to give a precipitate. The solid was collected by filtration to give the title material (3.559 g) as a solid. The filtrate was concentrated to dryness and the resulting solid was dissolved in boiling methanol and allowed to precipitate overnight aided with the addition of some water. The solid was collected by filtration, washed with water and air dried to give the title material (1.451 g) as a solid. The aqueous layer from the extraction was acidified with 10% HCl and a precipitate was formed. The solid was collected by filtration, washed with water to give the title material (1.559 g) as a solid. The solids were combined to give the title material (6.569 g, 95%). 1H NMR (400 MHz, DMSO-d6) delta (ppm): 2.53 (3H, s), 6.90 (1H, s), 7.21 (1H, d, J=3.5 Hz), 7.46 (1H, d, J=3.5 Hz), 11.87 (1H, s). LC/MS (M+H)+: 227, 229. HPLC ret. time (Condition E): 1.427 min.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1780-26-3, 2-Methyl-4,6-dichloropyrimidine.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; US2010/48581; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 1780-26-3, Adding some certain compound to certain chemical reactions, such as: 1780-26-3, name is 2-Methyl-4,6-dichloropyrimidine,molecular formula is C5H4Cl2N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1780-26-3.

Example 145 Synthesis of 2-(4-{6-[7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-ylamino]-2-methyl-pyrimidin-4-yl}-piperazin-1-yl)-ethanol To synthesize the title compound (CLXIX), two intermediate compounds 62 (2-[4-(6-chloro-2-methyl-pyrimidin-4-yl)-piperazin-1-yl]-ethanol) and 63 (7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-ylamine) shown below were used. To synthesize compound 62, to a solution of 4,6-dichloro-2-methyl-pyrimidine (5.0 g, 31 mmol) and 2-piperazin-1-yl-ethanol (2.7 g, 21 mmol) in dioxane (25 mL) was added DIPEA (3.0 mL, 17 mmol). The mixture was heated at reflux for 16 h. The mixture was allowed to cool to room temperature and poured into water. The reaulting aqueous layer was extracted with EtOAc and the combined organic layers washed with brine, dried over Na2SO4 and filtered. The filtrate was concentrated and the residue purified by flash chromatography on silica gel (5-10% MeOH/DCM) to afford compound 62 as a brown liquid (2.1 g, 39%). MS (ESI+): m/z 257.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1780-26-3, 2-Methyl-4,6-dichloropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TargeGen, Inc.; US2005/245524; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 1780-26-3 ,Some common heterocyclic compound, 1780-26-3, molecular formula is C5H4Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Into aclean and dry 5 L 4 N round bottom flask connected to a mechanical stirrer and equipped with a condenser and thermometer socket is charged under stirring, 200 g of 2-amino-thiazole-N-(2-chloro-6-methylphenyl)-5-carboxamide, 146 g of 4,6-dichloro-2-methylpyrimidine and 2 L of THF under a nitrogen atmosphere. After clear solution, cooled the mass temperature to 10-20 C. Added 30 % sodium-t-butoxide solution to the reaction mass over a period of 60-75 min at 10-20 C and brown coloured solution formation is observed. Raised the reaction mass temperature to 25-30 C and maintained the mass temperature to 25-30 C for 90-120 min. After HPLC compliance cooled the mass temperature to 0-5 C and added 2 N HCl solution to the reaction mass over a period of 60-90 min at 0-5 C. Maintained the mass temperature at 0-5 C for 105-120 min and transferred the reaction mass into a Buchner funnel and flask kept under plant vacuum. Washed the wet cake with 600.0 mL of water and dried the wet material in a drier at 60-65 C for 8-10 h gave 210.0 g of the title compound with purity above 99 %. Off white colour solid; Elemental analysis C16H13N5OSCl2calcd (found) %: C 48.74 (48.91), H 3.32 (3.45), N 17.76 (15.97),O 4.06 (4.24), S 8.13 (8.29). IR (KBr, numax, cm-1): 3424.28,3241.22, 2876.23-2789.82, 1638.82, 770.36; 1H NMR (400MHz, DMSO-d6): delta2.247 (s, 3H, -CH3), 2.594 (s, 3H, -CH3),6.952 (s, 1H, ArH), 7.252-7.314 (m, 2H, ArH), 7.403-7.422(dd, 1H, ArH), 8.320 (s, 1H, ArH), 10.030 (s, 1H, -NH), 12.251(s, 1H, -NH); 13C NMR (100 MHz, DMSO-d6): delta167.38, 161.23,159.52, 158.48, 157.51, 140.76, 138.74, 133.28, 132.35, 129.02,128.24, 127.18-126.99, 103.40, 66.97, 25.12, 18.23; ESI-MS(m/z): 394.14 (M+1), 396.15 (M+3).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1780-26-3, its application will become more common.

Reference:
Article; Buchappa; Sagar Vijay Kumar; Durga Prasad; Aparna; Asian Journal of Chemistry; vol. 30; 7; (2018); p. 1621 – 1628;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia