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New downstream synthetic route of 1780-26-3

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1780-26-3, 2-Methyl-4,6-dichloropyrimidine.

1780-26-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1780-26-3, name is 2-Methyl-4,6-dichloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

To 12 ml of 1,4-dioxane, 0.75 g of phenylboronic acid, 1.67 g of potassium carbonate, 0.13 g of dichlorobis (triphenylphosphine) palladium and 1 g of 4,6- dichloro-2-methylpyrimidine were added. This mixture was stirred at 60C for 3 hours and then stirred at 800C for 6 hours. The reaction mixture was left standing to cool to room temperature, poured into an aqueous saturated ammonium chloride solution and then extracted three times with tert- butyl methyl ether. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and then concentrated. The residue was subjected to silica gel column chromatography to obtain 0.64 g of 4-chloro-2-methyl- 6-phenylpyrimidine.4-chloro-2-methyl-6-rhohenylpyrimidine 1 H-NMR : 2 . 78 ( s , 3H ) , 7 . 49-7 . 56 (m, 4H ) , 8 . 04 -8 . 07 (m, 2H )

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; MIZUNO, Hajime; WO2010/134478; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Some tips on 1780-26-3

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1780-26-3, 2-Methyl-4,6-dichloropyrimidine, other downstream synthetic routes, hurry up and to see.

1780-26-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1780-26-3, name is 2-Methyl-4,6-dichloropyrimidine, molecular formula is C5H4Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a cooled solution of 2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5- carboxamide( 100 gm) and 4,6-Dichloro-2-methylpyrimidine(66. 96 gm) in THF(5 00 ml), was added sodium tert-butoxide(125.62 gm). The reaction mixture was allowed to cooled at 0-10C. Concentrated HC1 (80 ml) was added. The reaction mixture was heated to 25¡À5C for 1-2h and was cooled to 0-10C. The precipitated solid was filtered, washed with water (200 ml) and dried to obtain N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2- methylpyrimidin-4-yl) amino] -1, 3 -thiazole-5 -carboxamide (90gm).

Reference:
Patent; ALEMBIC PHARMACEUTICALS LIMITED; JAYARAMAN, Venkatraman; PATEL, Samir; MISTRY, Samir; PARMAR, Bhupendra; WO2015/49645; (2015); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The origin of a common compound about 1780-26-3

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1780-26-3, its application will become more common.

1780-26-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1780-26-3 as follows.

To a slurry of 4,6-dichloro-2-methylpyrirnidine (1-1) (5.00 g, 30.67 mmol, 1.0 eq.) and cesium carbonate (15.0 g, 46.05 mmol, 1.5 eq.) in DMF (250 mL) at 0 C under nitrogen was added a solution of 3,5-dimethyl-lH-l,2,4-triazole (2.98 g, 30.67 mmol, 1.0 eq.) in DMF (50 mL) via a dropping funnel over 1 hour. The reaction was then warmed to room temperature and stirred for 1 hour. The reaction was quenched by addition of water (500 mL) and extracted with ethyl acetate (3 x 400 mL). The combined organic layers were dried over sodium sulfate, filtered and concentrated to dryness. The crude product was purified by silica gel column chromatography (0-30% ethyl acetate in hexanes) to afford 4-chloro-6-(3,5-dimethyl-lH-l,2,4-triazol-l-yl)-2-methylpyrimidine (1-2) as a white solid. ‘Eta NMR (300 MHz, CDC13) delta 7.75 (s, 1H), 2.91 (s, 3H), 2.72 (s, 3H), 2.41 (s, 3H). LRMS mlz (M+Ff) 224 found, 224 required.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1780-26-3, its application will become more common.

Reference:
Patent; MERCK SHARP & DOHME CORP.; COX, Christopher, D.; DUDKIN, Vadim, Y.; KIM, June, J.; KUDUK, Scott, D.; MCVEAN, Carol; REGER, Thomas; STEEN, Justin; STEELE, Thomas; WO2013/52526; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Some tips on 1780-26-3

The chemical industry reduces the impact on the environment during synthesis 1780-26-3, I believe this compound will play a more active role in future production and life.

Into clean and dry 5.0 L 4-neck RB flask charged 2-amino-N-(2-chloro-6-methyl (0125) phenyl)-5-thiazole-l-carboxamide (200gm), 4,6-dichloro-2-methyl (0126) pyrimidine(146 g), 2.0 L of THF under nitrogen atmosphere. Clear solution (0127) formation was observed, cooled the reaction mass to temperature 10-20C, added (0128) 30% sodium -t-butoxide (845gm) solution to the reaction mass over a period of 60- (0129) 75min at temperature 10-20C. Brown coloured solution formation was observed. (0130) Reaction mass temperature was raised to 25-30C and maintained the reaction (0131) mass temperature to 25-30C for 90-120 min, cooled the mass to temperature 0- (0132) 5C and added 2N HCl solution to the reaction mass over a period of 60-90min at 0-5C and maintained for 105-120min. Transferred the reaction mass into a buchner funnel and flask kept under plant vacuum. Washed the wet cake with 600.0mlof water.Suck dried thoroughly for 45-60 mi and dried the wet material in a drier at temperature 60-65 C for 8-10hrs. (0133) Weight: 210 gm

The chemical industry reduces the impact on the environment during synthesis 1780-26-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; NATCO PHARMA LIMITED; KONAKANCHI, Durga Prasad; GONGALLA, Buchappa; KOTRA, Uma Naresh Babu; SAKKANI, Srinivasulu; RAGIDI, Dharmender; SIKHA, Kotayyababu; NANNAPANENI, Venkaiah Chowdary; (18 pag.)WO2018/100585; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Analyzing the synthesis route of 1780-26-3

With the rapid development of chemical substances, we look forward to future research findings about 1780-26-3.

Adding a certain compound to certain chemical reactions, such as: 1780-26-3, 2-Methyl-4,6-dichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1780-26-3, blongs to pyrimidines compound. 1780-26-3

Example 9; 4-(l-{ [6-(2-Methoxy-phenyl)-2-methyl-pyrimidin-4-yll-hvdrazono}-ethyl)- phenyll -dimethylamine; Step-1; 4-Chloro-6-hydrazino-2-methylpyrimidine; To a solution of 4,6-dichloro-2-methylpyrimidine (1Og, 0.061 mo 1) in dry THF (500ml) was added anhydrous hydrazine (1.96g, 0.06 lmol) followed by potassium carbonate (12.7g, 0.092mol). The reaction mixture was stirred at room temperature for 13h and filtered. The filtrate was evaporated under reduced pressure to afford 9.3g (45%) of the titled compound as a solid.MP: 164-1720C, MS: Mass found (M+l, 158.9), 1H NMR (CDCl3, 300MHz): delta 2.49(3H, s), 3.05(2H, bs), 6.59(1H, bs), 6.67(1H, s).; Example 27; N-[6-(2-Fluoro-phenyl)-2-methyl-pyrimidin-4-yll-N’-[l-p-tolyl- ethylidenel -hydrazine; Step-1; 4-Chloro-6-hydrazino-2-methylpyrimidine; To a solution of 4,6-dichloro-2-methylpyrimidine (1Og, 0.061 mo 1) in dry THF (500ml) was added anhydrous hydrazine (1.96g, 0.06 lmol) followed by potassium carbonate (12.7g, 0.092mol). The reaction mixture was stirred at room temperature for 13h and filtered. The filtrate was evaporated under reduced pressure to afford 9.3g (45%) of the titled compound as a solid.LCMS: Mass found (M+l, 158.9), MP: Started melting at 1460C and decomposed at 22O0C, 1H NMR (CDCl3, 300MHz): delta 2.49(3H, s), 3.05(2H, bs), 6.59(1H, bs), 6.67(1H, s).

With the rapid development of chemical substances, we look forward to future research findings about 1780-26-3.

Reference:
Patent; APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.; WO2007/65940; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Brief introduction of 1780-26-3

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1780-26-3, its application will become more common.

1780-26-3, Adding a certain compound to certain chemical reactions, such as: 1780-26-3, 2-Methyl-4,6-dichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1780-26-3, blongs to pyrimidines compound.

Part A Preparation of 4-Chloro-2-methyl-6-(4-morpholino)pyrimidine by Scheme I, Step (5) A solution of 5.00 g (31.7 mmole) of 4,6-dichloro-2-methylpyrimidine and 6.00 g (68.9 mmole) of morpholine in 50 ml of water was heated on a steam cone for about 18 hours. The mixture was diluted with water and cooled. The white solid was separated by filtration, washed with water and dried to provide 4.84 g (72%) of 4-chloro-2-methyl-6-(4-morpholino)pyrimidine. The structural assignment was confirmed by infrared and nuclear magnetic resonance spectral analyses.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1780-26-3, its application will become more common.

Reference:
Patent; Riker Laboratories, Inc.; US4477450; (1984); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Some scientific research about 1780-26-3

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1780-26-3.

Adding some certain compound to certain chemical reactions, such as: 1780-26-3, name is 2-Methyl-4,6-dichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1780-26-3. 1780-26-3

20 mmol of 4,6-dichloro-2-methylpyrimidine, 40mmol K3PO4 was dissolved in 100mL N,N-dimethylacetamide, stirring,0.3 mmol of 1-butyl-3-methylimidazolium glycinate and 22 mmol of N-hydroxyethylpiperazine were added in this order, and the mixture was reacted at 80 C for 2 h, and then cooled to room temperature. Add 22 mmol of 2-amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide, The reaction was continued at 80 C for 3 h. After the reaction was completed, it was cooled to room temperature and poured into ice water. It was extracted with ethyl acetate three times (3¡Á50 mL), and the ethyl acetate phase was combined. The organic layer was washed with anhydrous Na2SO4 to give a crude product. The crude product was added to 100 mL of an 80% aqueous ethanol solution, and 2 g of activated carbon was added thereto with stirring. After refluxing for 30 min, it was filtered while hot, and the filtrate was recrystallized overnight and filtered. The filter cake was washed with ice-cold 80% aqueous ethanol and dried. That is, 8.72 g of a white solid was obtained, the yield was 89.31%, and the purity was 99.94%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1780-26-3.

Reference:
Patent; Shandong Luoxin Pharmaceutical Group Co., Ltd.; Shandong Luoxin Pharmaceutical Group Hengxin Pharmaceutical Co., Ltd.; Shandong Yuxin Pharmaceutical Co., Ltd.; Li Mingjie; Li Chenglong; Li Cheng; (12 pag.)CN109678853; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Analyzing the synthesis route of 1780-26-3

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1780-26-3, its application will become more common.