Reference of 1780-27-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1780-27-4, name is 4,5,6-Trichloropyrimidine, molecular formula is C4HCl3N2, molecular weight is 183.42, as common compound, the synthetic route is as follows.
0.56 g of sodium hydride (60% oil suspention) was suspended in 18 ML of tetrahydrofuran. 2 ml of tetrahydrofuran solution of 0.8 g of 2-BUTYN-1-OL was added dropwise at room temperature therein slowly, and the mixture was stirred for 20 minutes. Into the mixture was added dropwise 5 ml of tetrahydrofuran solution of 3 g of 4,5, 6-TRICHLOROPYRIMIDINE at 0C slowly, and stirred for 2 hours. The reaction mixture was poured into a saturated ammonium chloride aqueous solution, and the mixture was extracted with ethyl acetate three times. The organic layers were washed with a saturated sodium chloride aqueous solution, dried over anhydrous magnesium sulfate and concentrated. The residue was subjected to silica gel column chromatography to obtain 2.23 g of 4, 5-DICHLORO-6- (2-BUTYNYLOXY) pyrimidine. LH-NMR : 1.88 (t, 3H), 5.08 (q, 2H), 8.48 (s, 1H)
Statistics shows that 1780-27-4 is playing an increasingly important role. we look forward to future research findings about 4,5,6-Trichloropyrimidine.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2004/99160; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia