Category: 1780-32-1

Synthetic Route of 1780-32-1 ,Some common heterocyclic compound, 1780-32-1, molecular formula is C6H6Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of RJ1-008 (0.500 g, 2.82 mmol), 3-amino-N-ri- butylbenzenesulfonamide (SG1-137) (0.74 g, 3.24 mmol), MeOH (5 mL), and water (7.5 mL) was heated to reflux at 40 C. The reflux temperature was raised to 80 C and the reaction was further heated for 26 hours. Upon cooling to ambient temperature, the precipitate which formed was then filtered and washed with water (50 mL) to yield RJl-010 as an off-white solid (0.649 g, 62%). m.p. = 232 C (decomposed). lH NMR (400 MHz, DMSO-ifc) delta 8.99 (s, 1H), 8.05 (s, 1H), 7.82-7.78 (m, 1H), 7.53-7.50 (m, 3H), 2.33 (s, 3H), 2.16 (s, 3H), 1.11 (s, 9H). LRMS (ESI+) m/z 369.2 (M35C1+H)+, 371.2 (M37C1+H)+; (ESI-) m/z 367.2 (M35C1-H)-, 369.2 (M37C1- H)-; HRMS (ESI+) m/z calculated for C16H21CIN4O2S (M+H)+ 369.11465, found 369.11431.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1780-32-1, its application will become more common.

Reference:
Patent; H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, INC.; SCHOeNBRUNN, Ernst; LAWRENCE, Nicholas J.; LAWRENCE, Harshani R.; (293 pag.)WO2017/66428; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1780-32-1, name is 2,4-Dichloro-5,6-dimethylpyrimidine, molecular formula is C6H6Cl2N2, molecular weight is 177.03, as common compound, the synthetic route is as follows.Formula: C6H6Cl2N2

After 1-methoxymethyl-1,2,3,4-tetrahydroisoquinolin(0.5 g, 2.82 mmol) and triethylamine(0.4 ml, 2.82 mmol) were added to a suspension of 5,6-dimethyl-2,4-dichloropyrimnidine(0.48 g, 2.68 mmol) in dimethylformamide (5 ml), 0.5 g of the titled compound was obtained in accordance with the same procedure as in Step 1 of Example 35.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1780-32-1, 2,4-Dichloro-5,6-dimethylpyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Yuhan Corporation; US6352993; (2002); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1780-32-1, name is 2,4-Dichloro-5,6-dimethylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 1780-32-1

To a solution of 2,4-dichloro-5,6-dimethylpyrimidine (0.800 g, 4.55 mmol) in EtOH (40 mL) were added Na2CO3 (2.42 g, 22.8 mmol) and 1H-indazol-5-amine (0.605 g, 4.55 mmol). The resulting mixture was stirred for 12 h at 100 C. The solvent was removed under reduced pressure and the residue was poured into water (50 mL) and extracted with EtOAc (3 x 100 mL). The organic phase was dried over Na2 SO4, filtered and concentrated under reduced pressure to give a residue which was purified by column chromatograph on silica gel (eluted with PEEA = 1:1) to provide the title compound (120 mg, yield: 9.7%) as a white solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1780-32-1, 2,4-Dichloro-5,6-dimethylpyrimidine.

Reference:
Patent; KADMON CORPORATION, LLC; KIM, Ji-in; LIU, Kevin; POYUROVSKY, Masha; LU, Dan; ZHU, Zhenping; WO2015/54317; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia