Category: 1780-36-5

Reference of 1780-36-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1780-36-5, name is 2,4,6-Trichloro-5-methylpyrimidine. A new synthetic method of this compound is introduced below.

[00275] Step 1: Synthesis of (R)-2,6-dichloro-5-methyl-N-(tetrahydrofuran-3-yl) pyrimidin-4-amine. A mixture of 2,4,6-trichloro-5-methylpyrimidine (2 g, 10.2 mmol), (R)- tetrahydro- furan-3-amine hydrochloride (1.12 g, 9.2 mmol) and Et3N (2.1 g, 20.3 mmol) in EtOH (20 mL) was stirred at room temperature for 14h., concentrated under vacuum and the residue was purified by chromatographic column on silica gel (EtOAc/petroleum ether, gradient elution, from 1/10 to 2/1) to give the (R)-2,6-dichloro-5-methyl-N- (tetrahydrofuran -3-yl)pyrimidin-4-amine (1.25 g, 53% yield) as a white solid. ESI-LCMS (m/z): 248.1[M+1]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1780-36-5, its application will become more common.

Reference:
Patent; EPIZYME, INC.; CHESWORTH, Richard; MORADEI, Oscar, Miguel; SHAPIRO, Gideon; JIN, Lei; BABINE, Robert, E.; (495 pag.)WO2016/44641; (2016); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 1780-36-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1780-36-5, name is 2,4,6-Trichloro-5-methylpyrimidine. A new synthetic method of this compound is introduced below.

(c) Production of 4-amino-2,6-dichloro-5-methylpyrimidine 39.5 g (0.2 mol) of 5-methyl-2,4,6-trichloropyrimidine are dissolved in 250 ml of dimethoxyethane, and ammonia gas is then introduced at room temperature until the solution is saturated. A white suspension is formed, which is stirred for 12 hours at room temperature; it is subsequently concentrated in a rotary evaporator, and 200 ml of water are added to the residue. The formed suspension is filtered and the precipitate is dried. The mother liquor is concentrated to half the volume, filtered, and the precipitate is dried. There are thus obtained 26.4 g of crude product, which is recrystallized from acetonitrile/water (5:1); m.p. 193-194 C. (yield=75% of theory). Analysis: calculated: C 33.74%, H 2.83%, N 23.61%, Cl 39.83%, found: C 33.80%, H 2.87%, N 23.44%, Cl 39.51%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1780-36-5, 2,4,6-Trichloro-5-methylpyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Ciba-Geigy Corporation; US4741760; (1988); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia