Category: 1780-40-1

Application of 1780-40-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1780-40-1, name is 2,4,5,6-Tetrachloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

Step 1 4-[(2,5,6-Trichloro-pyrimidin-4-ylamino)-methyl]-piperidine-1-carboxylic acid benzyl ester To a solution of benzyl 4-(aminomethyl)piperidine-1-carboxylate (EXAMPLE 13, Step 1) and N,N-diisopropylethylamine (2.6 g, 20 mmol) in THF (40 mL) at -78 C. was added a solution of tetrachloropyrimidine (4.4 g, 20 mmol). The cooling bath was removed and the solution was stirred for 45 min. The solution was concentrated and purified by filtering through a pad of silica gel using ether.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1780-40-1, 2,4,5,6-Tetrachloropyrimidine.

Reference:
Patent; Claiborne, Christopher F.; Butcher, John W.; Claremon, David A.; Libby, Brian E.; Liverton, Nigel J.; Munson, Peter M.; Nguyen, Kevin T.; Phillips, Brian; Thompson, Wayne; McCauley, John A.; US2002/165241; (2002); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 1780-40-1 ,Some common heterocyclic compound, 1780-40-1, molecular formula is C4Cl4N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 2,4,5,6-tetrachloropyrimidine (5 g, 22.9 mmol) in THF (50 mL) was added iN NaOH (31 mL, 31.2 mmol) dropwise, and the mixture was stirred overnight at RT. The solution was acidified with iN HC1 and extracted with DCM (3x). The organics were combined, dried, and concentrated in vacuo. The solids were slurried in Et20 for 30 mm at RT, filtered, washed with Et20, and dried to give 3.0 g (66%) of the title compound. [M+H] Calc?d for C4HC13N2O, 201; Found, 201.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1780-40-1, 2,4,5,6-Tetrachloropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; QUANTICEL PHARMACEUTICALS, INC.; CHEN, Young, K.; KANOUNI, Toufike; KALDOR, Stephen, W.; STAFFORD, Jefrey, Alan; VEAL, James, Marvin; WO2015/168466; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1780-40-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1780-40-1, name is 2,4,5,6-Tetrachloropyrimidine, molecular formula is C4Cl4N2, molecular weight is 217.8682, as common compound, the synthetic route is as follows.

To a solution of 2,4,5, 6-tetrachloropyrimidine (1 kg, 4.63 mol) in THF (6 L) was added IN NaOH (6 L, 6.0 mol) drop wise, and the mixture was stirred overnight at room temperature. The solution was acidified with IN HC1 and extracted with DCM (3x). The combined organics were dried (Na2S04) and concentrated in vacuo. The solids were slurried in Et20 for 30 min, filtered, washed with Et20 and dried to give 635 g (69%) of the title compound. LCMS (C18 column, column size: 4.6*50 mm; mobile phase: 20%-40%, Acetonitrile-Water-0.02% NH4OAc): Rt= 2.785 min; [M+H] Calc’d for C4HC13N20, 199; Found, 199.

Statistics shows that 1780-40-1 is playing an increasingly important role. we look forward to future research findings about 2,4,5,6-Tetrachloropyrimidine.

Reference:
Patent; CELGENE QUANTICEL RESEARCH, INC.; CHEN, Young K.; KANOUNI, Toufike; KALDOR, Stephen W.; STAFFORD, Jeffrey Alan; VEAL, James Marvin; TAVARES-GRECO, Paula Alessandra; KREILEIN, Matthew Michael; (41 pag.)WO2017/79670; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 1780-40-1 ,Some common heterocyclic compound, 1780-40-1, molecular formula is C4Cl4N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In a 250 mL three-neck flask fitted with a degassing tube and temperature probe, acetonitrile (100 mL) and water (25 mL) were degassed with nitrogen for 30 min while stirring. 2,4,5,6-Tetrachloropyrimidine (8.77 g, 0.0402 mol, 1.5 equiv) and triphenylphosphine (0.70 g, 2.6 mmol, 0.1 equiv) were added and degassed for 15 min. 5-Chloro-2-methoxyphenylboronic acid (5.00 g, 0.0268 mol, 1.0 equiv), potassium phosphate (11.39 g, 0.0536 mol, 2.0 equiv) and palladium acetate (301 mg, 1.3 mmol, 0.05 equiv) were added and degassed for 5 min. The reaction was complete after 2 h at room temperature. The reaction mixture was added to 250 mL CH2Cl2. The organic layer was washed twice with water (125 mL), dried over Na2SO4, and concentrated. The crude product was purified by silica gel column chromatography. The product was obtained as a white solid (5.97 g, 69%). 1H NMR (500 MHz, CDCl3, delta): 7.45 (dd, J=8.9, 2.6 Hz, 1H), 7.31 (d, J=2.6 Hz, 1H), 6.94 (d, J=8.9 Hz, 1H), 3.82 (s, 3H); MS (ESI+): calculated for C11H6Cl4N2O, 321.92; m/z found, 323.0 [M+H+].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1780-40-1, 2,4,5,6-Tetrachloropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Fitzgerald, Anne E.; Liu, Jing; Mani, Neelakandha S.; US2009/76268; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1780-40-1, name is 2,4,5,6-Tetrachloropyrimidine, the common compound, a new synthetic route is introduced below. Formula: C4Cl4N2

(4.408 mmol) of 4- (10H-phenoxazin-10-yl) phenylboronic acid were successively added,(0.92 mmol) of 2,4,5,6-tetrachloropyrimidine,103 mg (0.46 mmol) of palladium acetate,241 mg (0.92 mmol) of triphenylphosphine as well1.17 g (11.04 mmol) of anhydrous potassium carbonate was added100ml three-mouth flask,Then, 50 mL of ethylene glycol dimethyl ether was added as a reaction solvent,Air was removed and refluxed for 24 h.After completion of the reaction, the reaction solvent was distilled off under reduced pressure, and the mixture was extracted three times with DCM and then dried by passing through a column.To give 0.38 g of a yellow solid,Yield 38.6%.

The synthetic route of 1780-40-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Dalian University of Technology; Liu, Di; Zhang, Dan; (16 pag.)CN106243086; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 1780-40-1 , The common heterocyclic compound, 1780-40-1, name is 2,4,5,6-Tetrachloropyrimidine, molecular formula is C4Cl4N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 2,4,5,6-tetrachloropyrimidine (5 g, 22.9 mmol) in THF (50 mL) was added 1N NaOH (31 mL, 31.2 mmol) dropwise, and the mixture was stirred overnight at RT. The solution was acidified with 1N HCl and extracted with DCM (3x). The organics were combined, dried, and concentrated in vacuo. The solids were slurried in Et2O for 30 min at RT, filtered, washed with Et2O, and dried to give 3.0 g (66%) of the title compound. [M+H] Calc?d for C4HCl3N2O, 201; Found, 201.

The synthetic route of 1780-40-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CELGENE CORPORATION; XU, Jiangchun; CHO, Robert; NGUYEN, Aaron; (297 pag.)WO2018/31658; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1780-40-1, name is 2,4,5,6-Tetrachloropyrimidine, molecular formula is C4Cl4N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 2,4,5,6-Tetrachloropyrimidine

A hydroxyl group-containing tertiary amine betaine was prepared according to the method of Example 1.The tertiary amine betaine was dissolved in 500 mL of deionized water and added to a round bottom flask with mechanical stirring,Cool to about 10 C.108.5g of 2,4,5,6-tetrachloropyrimidine fine powder was added under stirring, and after stirring well,A solution of 26 g of sodium carbonate dissolved in 50 mL of deionized water was added portion wise with stirring.After adding continue to react 3 ~ 5h.Then slowly add potassium acetate to the reaction solution to precipitate the product, after filtration and washed with anhydrous ethanol,Vacuum drying to obtain a trichloropyrimidine active group tertiary amine betaine antibacterial agent.

With the rapid development of chemical substances, we look forward to future research findings about 1780-40-1.

Reference:
Patent; Hong Kong Polytechnic University; Xin Haozhong; He Liang; Gao Chang; (17 pag.)CN106928158; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia