Adding a certain compound to certain chemical reactions, such as: 1791-73-7, 6-Methyl-2,4-pyrimidinediamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 6-Methyl-2,4-pyrimidinediamine, blongs to pyrimidines compound. Recommanded Product: 6-Methyl-2,4-pyrimidinediamine
Step B Synthesis of 2,4-diamino-5-iodo-6-methylpyrimidine as an intermediate A solution of 8.0 grams (0.064 mole) of 2,4-diamino-6-methylpyrimidine in 30 mL of glacial acetic acid is stirred, and a solution of 13.5 grams (0.083 mole) of iodine monochloride in 20 mL of glacial acetic acid is added dropwise during a 5 minute period. Upon completion of addition, the reaction mixture is stirred at ambient temperature for about 18 hours. After this time the reaction mixture is diluted with 100 mL of water and then is made basic with 10% aqueous sodium hydroxide. The mixture is then extracted with three 75 mL portions of ethyl acetate. The combined extracts are washed with one 75 mL portion of an aqueous solution saturated with sodium chloride. The organic layer is dried with sodium sulfate and filtered. The filtrate is concentrated under reduced pressure, yielding 11.7 grams of 2,4-diamino-5-iodo-6-methylpyrimidine. The NMR spectrum is consistent with the proposed structure.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1791-73-7, 6-Methyl-2,4-pyrimidinediamine, and friends who are interested can also refer to it.
Reference:
Patent; FMC Corporation; US5622954; (1997); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia