Electric Literature of 181950-57-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 181950-57-2 as follows.
To a 100 ml round bottom flask was added 4-chloro-7-hydroxy quinoline (0.89 g, 5 mmol)Acetone (40 ml) and anhydrousK2C03 (2.0 g) was stirred at room temperature for 15 minutes,Followed by the addition of iodo butane (20 mmol)TLC trace detection.Reaction is completed,The acetone was distilled off under reduced pressure, 150 mL of water was added and the mixture was extracted with ethyl acetate. The combined organic phases were acidified by adding concentrated hydrochloric acid,With water to give a yellow oil, recrystallized from acetone, precipitated white crystals, filtered and basified to give a white solid ( 0.57 g Rate of 47.6%)
According to the analysis of related databases, 181950-57-2, the application of this compound in the production field has become more and more popular.