Category: 18260-92-9

Safety of 6-Chloro-2,5-dimethylpyrimidin-4-amineOn November 10, 1998 ,《Crystal structure of thiaminase-I from Bacillus thiaminolyticus at 2.0 Å resolution》 appeared in Biochemistry. The author of the article were Campobasso, Nino; Costello, Colleen A.; Kinsland, Cynthia; Begley, Tadhg P.; Ealick, Steven E.. The article conveys some information:

Thiaminase I (I) catalyzes the replacement of the thiazole moiety of thiamin with a wide variety of nucleophiles, such as pyridine, aniline, catechols, quinoline, and cysteine. Here, the crystal structure of I from B. thiaminolyticus was determined at 2.5 Å resolution by multiple isomorphous replacement and refined to an R factor of 0.195 (Rfree = 0.272). Two other structures, one native and one containing a covalently bound thiamin analog inhibitor, were determined at 2.0 Å resolution by mol. replacement from a 2nd crystal form and were refined to R factors of 0.205 and 0.217 (Rfree = 0.255 and 0.263), resp. The overall structure contained 2 α/β-type domains separated by a large cleft. At the base of the cleft was Cys-113, previously identified as a key active site nucleophile. The structure with a covalently bound thiamin analog, 4-amino-6-chloro-2,5-dimethylpyrimidine, which functions as a mechanism-based inactivating agent, confirmed the location of the active site. Glu-241 appeared to function as an active site base to increase the nucleophilicity of Cys-113. I mutant E241Q was constructed and was found to exhibit no activity. I shows no sequence identity to other proteins in the sequence databases, but the 3-dimensional structure showed very high structural homol. to periplasmic binding proteins and transferrins.6-Chloro-2,5-dimethylpyrimidin-4-amine(cas: 18260-92-9Safety of 6-Chloro-2,5-dimethylpyrimidin-4-amine) was used in this study.

6-Chloro-2,5-dimethylpyrimidin-4-amine(cas: 18260-92-9) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Safety of 6-Chloro-2,5-dimethylpyrimidin-4-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Decomposition of thiamine in alcohol solution. II》 was published in Chemical & Pharmaceutical Bulletin in 1974. These research results belong to Shimahara, Noboru; Asakawa, Hiroyuki; Kawamatsu, Yutaka; Hirano, Hiroshi. COA of Formula: C6H8ClN3 The article mentions the following:

Thiamine mononitrate I was decomposed in MeOH solution to produce the pentamer II and the thiazole III. II was converted to 9-amino-2,7,10-trimethyl-5H-dipyrimido[1,6-a:4′,5′-d]pyrimidine. Decomposition of thiamine monochloride in MeOH followed by AgNO3 gave II. II in aqueous solution reacted with acidic sodium sulfite to give 4-amino-2-methylpyrimidinyl-5-methanesulfonic acid. In the experiment, the researchers used many compounds, for example, 6-Chloro-2,5-dimethylpyrimidin-4-amine(cas: 18260-92-9COA of Formula: C6H8ClN3)

6-Chloro-2,5-dimethylpyrimidin-4-amine(cas: 18260-92-9) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.COA of Formula: C6H8ClN3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia