Category: 18436-73-2

COA of Formula: C10H8ClN. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4-Chloro-8-methylquinoline, is researched, Molecular C10H8ClN, CAS is 18436-73-2, about Human α1-adrenoceptor subtype selectivity of substituted homobivalent 4-aminoquinolines. Author is Chen, Junli; Campbell, Adrian P.; Urmi, Kaniz F.; Wakelin, Laurence P. G.; Denny, William A.; Griffith, Renate; Finch, Angela M..

A series of ring-substituted ethyl- and heptyl-linked 4-aminoquinoline dimers were synthesized and evaluated for their affinities at the 3 human α1-adrenoceptor (α1-AR) subtypes and the human serotonin 5-HT1A-receptor (5-HT1A-R). We find that the structure-specificity profiles are different for the two series at the α1-AR subtypes, which suggests that homobivalent 4-aminoquinolines can be developed with α1-AR subtype selectivity. The 8-Me ethyl-linked analog has the highest affinity for the α1A-AR, 7 nM, and the greatest capacity for discriminating between α1A-AR and α1B-AR (6-fold), α1D-AR (68-fold), and the 5-HT1A-R (168-fold). α1B-AR selectivity was observed with the 6-Me derivative of the ethyl- and heptyl-linked 4-aminoquinoline dimers and the 7-methoxy (7-OMe) derivative of the heptyl-linked analog. These substitutions result in 4- to 80-fold selectivity for α1B-AR over α1A-AR, α1D-AR, and 5-HT1A-R. In contrast, 4-aminoquinoline dimers with selectivity for α1D-AR are more elusive, since none studied to date has greater affinity for the α1D-AR over the other two α1-ARs. The selectivity of the 8-Me ethyl-linked 4-aminoquinoline dimer for the α1A-AR, and 6-Me ethyl-linked, and the 6-Me and 7-OMe heptyl-linked 4-aminoquinoline dimers for the α1B-AR, makes them promising leads for drug development of α1A-AR or α1B-AR subtype selective ligands with reduced 5-HT1A-R affinity.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

SDS of cas: 18436-73-2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 4-Chloro-8-methylquinoline, is researched, Molecular C10H8ClN, CAS is 18436-73-2, about Human α1-adrenoceptor subtype selectivity of substituted homobivalent 4-aminoquinolines.

A series of ring-substituted ethyl- and heptyl-linked 4-aminoquinoline dimers were synthesized and evaluated for their affinities at the 3 human α1-adrenoceptor (α1-AR) subtypes and the human serotonin 5-HT1A-receptor (5-HT1A-R). We find that the structure-specificity profiles are different for the two series at the α1-AR subtypes, which suggests that homobivalent 4-aminoquinolines can be developed with α1-AR subtype selectivity. The 8-Me ethyl-linked analog has the highest affinity for the α1A-AR, 7 nM, and the greatest capacity for discriminating between α1A-AR and α1B-AR (6-fold), α1D-AR (68-fold), and the 5-HT1A-R (168-fold). α1B-AR selectivity was observed with the 6-Me derivative of the ethyl- and heptyl-linked 4-aminoquinoline dimers and the 7-methoxy (7-OMe) derivative of the heptyl-linked analog. These substitutions result in 4- to 80-fold selectivity for α1B-AR over α1A-AR, α1D-AR, and 5-HT1A-R. In contrast, 4-aminoquinoline dimers with selectivity for α1D-AR are more elusive, since none studied to date has greater affinity for the α1D-AR over the other two α1-ARs. The selectivity of the 8-Me ethyl-linked 4-aminoquinoline dimer for the α1A-AR, and 6-Me ethyl-linked, and the 6-Me and 7-OMe heptyl-linked 4-aminoquinoline dimers for the α1B-AR, makes them promising leads for drug development of α1A-AR or α1B-AR subtype selective ligands with reduced 5-HT1A-R affinity.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 18436-73-2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 4-Chloro-8-methylquinoline, is researched, Molecular C10H8ClN, CAS is 18436-73-2, about Synthesis and in-vitro evaluation of new benzenesulfonamides as antileishmanial agents. Author is Borges, Julio C.; Carvalho, Adriana V.; Bernardino, Alice M. R.; Oliveira, Cesar D.; Pinheiro, Luiz C. S.; Marra, Roberta K. F.; Castro, Helena C.; Wardell, Solange M. S. V.; Wardell, James L.; Amaral, Veronica F.; Canto-Cavalheiro, Marilene M.; Leon, Leonor L.; Genestra, Marcelo.

The synthesis and the antileishmanial activity of sulfonamides I (R1 = H, Me, Cl, Br; R2 = H, Me; R3 = H, Me) was reported. In particular, compound I (R1 = H, R2 = Me, R3 = H) showed significant in-vitro activity against Leishmania amazonensis. Compounds I also were found to not show any toxicity to murine macrophage up to a concentration of 320μgL-1.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Category: pyrimidines. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 4-Chloro-8-methylquinoline, is researched, Molecular C10H8ClN, CAS is 18436-73-2, about Cp*CoIII-Catalyzed Alkylation of Primary and Secondary C(sp3)-H Bonds of 8-Alkylquinolines with Maleimides. Author is Kumar, Rakesh; Kumar, Rohit; Chandra, Devesh; Sharma, Upendra.

The cobalt(III)-catalyzed C(sp3)-H bond alkylation of 8-Me quinoline with maleimides is reported. In contrast to the rhodium-catalyzed method, in the current cobalt-catalyzed method, a catalytic amount of acid is used, and importantly, it is also applicable to secondary C(sp3)-H bond alkylation. The developed methodol. is applicable for N-alkyl- and N-aryl-substituted maleimides and unsubstituted maleimides, and it also tolerates the variety of functional groups on the 8-Me quinoline moiety. Atom-economy and high regioselectivity with good to excellent yields of the alkylated products under mild reaction conditions are important features of this method.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 4-Chloro-8-methylquinoline, is researched, Molecular C10H8ClN, CAS is 18436-73-2, about Cp*CoIII-Catalyzed Alkylation of Primary and Secondary C(sp3)-H Bonds of 8-Alkylquinolines with Maleimides.Safety of 4-Chloro-8-methylquinoline.

The cobalt(III)-catalyzed C(sp3)-H bond alkylation of 8-Me quinoline with maleimides is reported. In contrast to the rhodium-catalyzed method, in the current cobalt-catalyzed method, a catalytic amount of acid is used, and importantly, it is also applicable to secondary C(sp3)-H bond alkylation. The developed methodol. is applicable for N-alkyl- and N-aryl-substituted maleimides and unsubstituted maleimides, and it also tolerates the variety of functional groups on the 8-Me quinoline moiety. Atom-economy and high regioselectivity with good to excellent yields of the alkylated products under mild reaction conditions are important features of this method.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Recommanded Product: 4-Chloro-8-methylquinoline. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 4-Chloro-8-methylquinoline, is researched, Molecular C10H8ClN, CAS is 18436-73-2, about A mild and efficient method for the preparation of 3-(2′-aminoaryl)pyrazoles from 4-chloroquinolines. Author is Borges, Julio C.; de Oliveira, Cesar D.; da Silva Pinheiro, Luiz C.; Marra, Roberta K. F.; Khan, Misbahul Ain; Wardell, James L.; Wardell, Solange M. S. V.; Bernardino, Alice M. R..

The authors described a mild and efficient method for the formation of 3-(2′-aminoaryl)pyrazoles in excellent yields from reactions of 4-chloroquinolines with hydrazine. These heterocyclic ring opening reactions occur under much milder conditions then previously described. The structures of the compounds were determined by spectral data and confirmed by x-ray diffraction anal. of 3-(2′-amino-3′-methylphenyl)pyrazole [monoclinic, C2, a 25.9750(3), b 9.5820(6), c 7.8299(7) Å, β 107.541(3)°, V 1858.2(2) Å3, Z 8].

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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Formula: C10H8ClN. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 4-Chloro-8-methylquinoline, is researched, Molecular C10H8ClN, CAS is 18436-73-2, about Study of aminoquinolines. XIV: Long-chain 4-alkylaminoquinolines with potential amebicide activity. Part 2: Effect of the position of nuclear alkyl groups. Author is Renault, Sylviane; Renault, Jean; Cavier, Raymond.

Alkylaminoquinolines I (n = 7-17; R = 2-Me, 2-Ph, H, 3-Me; R1 = H, S-Me, 6-Me, 7-Me, 8-Me, 8-Et, 8-CHMe2) were prepared by aminating 4-chloroquinolines. The amebicidal activity of I was maximum when n = 7-9. Methylation of the ring had little effect on amebicidal activity. Some of the chloroquinolines were prepared by treating anilines with EtOCH:C(CO2Et)2 or AcCH2CO2Et, cyclizing, decarboxylating the quinolinecarboxylates, and chlorinating the quinolinol.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis of bicyclic N-arylmethyl-substituted iminoribitol derivatives as selective nucleoside hydrolase inhibitors, published in 2009-02-28, which mentions a compound: 18436-73-2, Name is 4-Chloro-8-methylquinoline, Molecular C10H8ClN, Category: pyrimidines.

The purine metabolism of Trypanosoma and Leishmania spp. provides a good target in the search for new selective drugs. Bicyclic N-arylmethyl-substituted iminoribitols were developed as inhibitors of T. vivax nucleoside hydrolase, a key enzyme of the purine salvage pathway. The obtained results and structure-activity data confirmed our model for inhibitor binding with a hydrogen bond between a nitrogen atom of the nucleobase mimetic and the protonated Asp40 from the enzyme. This interaction depends on an optimal pKa value, which can be influenced by the electronic properties of the substituents. These compounds are potent, selective inhibitors of nucleoside hydrolase and are inactive toward human nucleoside phosphorylase.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 4-Chloro-8-methylquinoline, is researched, Molecular C10H8ClN, CAS is 18436-73-2, about Synthesis and photochemistry of two quinoline analogs of the perimidinespirohexadienone family of photochromes.Computed Properties of C10H8ClN.

The authors report the detailed synthesis and photochem. of two analogs (specifically 3,5-di-tert-butyl-7′-methyl- and 3,5-di-tert-butyl-7′,9′-dimethyl-1′,3′-dihydrospirocyclohexa[2,5]diene-1,2′-pyrido[4,3,2-de]quinazolin-4-one) of the perimidinespirohexadienone (3,5-di-tert-butyl-1′,3′-dihydrospirocyclohexa[2,5]diene-1,2′-perimidin-4-one) family of photochromes in which the naphthalene moiety of the parent is replaced by a quinoline, and compare them to the parent compound Molar absorptivities of both the short wavelength spirocyclic isomer (SW) and long wavelength quinonimine isomer (LW) of each were determined by a combination of proton NMR and UV-vis spectroscopy in solvents of varying polarity. Quantum yield measurements for photoisomerization of SW to LW are reported in those same solvents, with qual. extrapolation to addnl. solvents. The position and rate of the thermal equilibrium reverting LW to SW is estimated for these compounds The 9′-Me in SW (6-Me in LW) is found to be essential for complete reversion of LW to SW in the dark. Finally one-dimensional NOE NMR spectroscopy was used to conclusively determine the structure of LW for the quinoline analogs as the 4-(5-aminoquinolin-4-ylimino)-2,6-di-tert-butylcyclohexa-2,5-dienone resulting from opening toward the quinoline nitrogen, rather than the 4-(4-aminoquinolin-5-ylimino) structure that would result from spirocyclic ring opening away from the quinoline nitrogen which had been initially proposed by V.I Minkin et al. (1999) for very similar compounds

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Pyrimidine | C4H4N2 – PubChem,
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Korodi, Ferenc published an article about the compound: 4-Chloro-8-methylquinoline( cas:18436-73-2,SMILESS:CC1=C2N=CC=C(Cl)C2=CC=C1 ).Quality Control of 4-Chloro-8-methylquinoline. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:18436-73-2) through the article.

Synthesis of 4-(1H-1,2,4-triazol-1-yl)quinolines by the reaction of 4-chloroquinolines with 1,2,4-triazole was studied under neutral, acidic and basic reaction conditions. The significant role of acid and base catalysis as well as substituent effects on the reactivity of 4-chloroquinolines in these reactions are reported.

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Pyrimidine | C4H4N2 – PubChem,
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