Category: 18436-73-2

Birkinshaw, Timothy N.; Teague, Simon J.; Beech, Claire; Bonnert, Roger V.; Hill, Stephen; Patel, Anil; Reakes, Sara; Sanganee, Hitesh; Dougall, Iain G.; Phillips, Tim T.; Salter, Sylvia; Schmidt, Jerzy; Arrowsmith, Elizabeth C.; Carrillo, Juan J.; Bell, Fiona M.; Paine, Stuart W.; Weaver, Richard published the article 《Discovery of potent CRTh2 (DP2) receptor antagonists》. Keywords: CRTh2 receptor antagonist discovery preparation antiinflammatory structure.They researched the compound: 4-Chloro-8-methylquinoline( cas:18436-73-2 ).Reference of 4-Chloro-8-methylquinoline. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:18436-73-2) here.

Starting with the weak agonist indomethacin, a series of potent, selective CRTh2(DP2) antagonists have been discovered as potential treatments for asthma, allergic rhinitis and other inflammatory diseases.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

SDS of cas: 18436-73-2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 4-Chloro-8-methylquinoline, is researched, Molecular C10H8ClN, CAS is 18436-73-2, about Discovery of potent CRTh2 (DP2) receptor antagonists.

Starting with the weak agonist indomethacin, a series of potent, selective CRTh2(DP2) antagonists have been discovered as potential treatments for asthma, allergic rhinitis and other inflammatory diseases.

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Pyrimidine | C4H4N2 – PubChem,
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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 18436-73-2, is researched, Molecular C10H8ClN, about Cp*CoIII-Catalyzed Alkylation of Primary and Secondary C(sp3)-H Bonds of 8-Alkylquinolines with Maleimides, the main research direction is cobalt catalyzed regioselective alkylation alkylquinoline maleimide.Formula: C10H8ClN.

The cobalt(III)-catalyzed C(sp3)-H bond alkylation of 8-Me quinoline with maleimides is reported. In contrast to the rhodium-catalyzed method, in the current cobalt-catalyzed method, a catalytic amount of acid is used, and importantly, it is also applicable to secondary C(sp3)-H bond alkylation. The developed methodol. is applicable for N-alkyl- and N-aryl-substituted maleimides and unsubstituted maleimides, and it also tolerates the variety of functional groups on the 8-Me quinoline moiety. Atom-economy and high regioselectivity with good to excellent yields of the alkylated products under mild reaction conditions are important features of this method.

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Pyrimidine | C4H4N2 – PubChem,
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Product Details of 18436-73-2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 4-Chloro-8-methylquinoline, is researched, Molecular C10H8ClN, CAS is 18436-73-2, about Nucleophilic substitution reaction of chloroquinolines with 1,2,4-triazole. I. Synthesis of 4-(1H-1,2,4-triazol-1-yl)quinolines. Author is Korodi, Ferenc.

Synthesis of 4-(1H-1,2,4-triazol-1-yl)quinolines by the reaction of 4-chloroquinolines with 1,2,4-triazole was studied under neutral, acidic and basic reaction conditions. The significant role of acid and base catalysis as well as substituent effects on the reactivity of 4-chloroquinolines in these reactions are reported.

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Pyrimidine | C4H4N2 – PubChem,
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HPLC of Formula: 18436-73-2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 4-Chloro-8-methylquinoline, is researched, Molecular C10H8ClN, CAS is 18436-73-2, about Synthesis and antimicrobial activity of novel substituted ethyl 2-(quinolin-4-yl)-propanoates. Author is Khan, M. Akram; Miller, Keith; Rainsford, Kim Drummond; Zhou, Yong.

4-Hydroxyquinolines were synthesized from anilines and EtOCH:C(CO2Et)2 by Gould-Jacobs reaction via cyclization of the intermediate (anilinomethylene)malonate followed by hydrolysis and decarboxylation. The 4-hydroxyquinolines reacted with POCl3 to form 4-chloroquinolines, which reacted on heating with Na+MeC-(CO2Et)2 in DMF to yield moderate yields of 2-(quinolin-4-yl)propanoates, many of which showed potent antimicrobial activity against Helicobacter pylori.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Well-defined palladium(II) complexes for ligand-enabled C(sp3)-alkynylation, published in 2015, which mentions a compound: 18436-73-2, mainly applied to palladium catalyst alkynylation methylquinoline; quinoline methyl alkynylation palladium catalyst, Safety of 4-Chloro-8-methylquinoline.

The first example of ligand-enabled C(sp3)-alkynylation of 8-methylquinoline is reported. The reaction is catalyzed by well-defined Pd(II) complexes. The present C(sp3)-alkynylation has a broad substrate scope as well as functional group tolerance and proceeds efficiently under mild conditions.

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Reference of 4-Chloro-8-methylquinoline. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 4-Chloro-8-methylquinoline, is researched, Molecular C10H8ClN, CAS is 18436-73-2, about Tricyclic heteroaromatic ring systems. II. A convenient synthesis of 1H-pyrrolo[3,2-c]quinolines. Author is Khan, Misbahul Ain; Ferreira de Rocha, Joao.

Quinol-4-yl hydrazones I (R = H, Me, Et; R1 = Me, Ph, Et; RR1 = (CH2)n, n = 3, 4; R2 = H, Me; R3 = H, 6-, 7-, 8-Cl, 6-, 7-, 8-Me, 6-, 7-, 8-MeO) on heating in high boiling solvents undergo cyclizations to give 1H-pyrrolo[3,2-c]quinolines II in good yields. Some of these I were alkylated to provide their N-alkyl derivatives

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of C10H8ClN. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 4-Chloro-8-methylquinoline, is researched, Molecular C10H8ClN, CAS is 18436-73-2, about Nucleophilic heteroaromatic substitution. XXVII. Piperidino dechlorination and methoxy dechlorination of 6- and 8-alkyl-4-chloroquinolines. Steric hindrance to specific solvation.

Kinetic data for the reaction of 6- and 8-alkyl-substituted 4-chloroquinolines with piperidine in four different solvents and with NaOMe in MeOH were obtained and compared. The tert-butyl group located at the position peri to the aza group is found to cause rate-depressing effects and significant increases in the energy and entropy of activation when the solvent is hydroxylic (methanol) whereas only minor changes are observed in aprotic or poor proton-donor solvents (toluene, HCONMe2, and piperidine). The results are interpreted in terms of steric inhibition of specific solvation (H bonding). 15 references.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 18436-73-2, is researched, Molecular C10H8ClN, about Tricyclic heteroaromatic ring systems. II. A convenient synthesis of 1H-pyrrolo[3,2-c]quinolines, the main research direction is pyrroloquinoline; quinolinyl hydrazone cyclization.Synthetic Route of C10H8ClN.

Quinol-4-yl hydrazones I (R = H, Me, Et; R1 = Me, Ph, Et; RR1 = (CH2)n, n = 3, 4; R2 = H, Me; R3 = H, 6-, 7-, 8-Cl, 6-, 7-, 8-Me, 6-, 7-, 8-MeO) on heating in high boiling solvents undergo cyclizations to give 1H-pyrrolo[3,2-c]quinolines II in good yields. Some of these I were alkylated to provide their N-alkyl derivatives

There is still a lot of research devoted to this compound(SMILES：CC1=C2N=CC=C(Cl)C2=CC=C1)Synthetic Route of C10H8ClN, and with the development of science, more effects of this compound(18436-73-2) can be discovered.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Computed Properties of C10H8ClN. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4-Chloro-8-methylquinoline, is researched, Molecular C10H8ClN, CAS is 18436-73-2, about Synthesis and photochemistry of two quinoline analogs of the perimidinespirohexadienone family of photochromes. Author is Moerdyk, Jonathan P.; Speelman, Amy L.; Kuper, Kenneth E.; Heiberger, Brian R.; Ter Louw, Ryan P.; Zeller, Daniel J.; Radler, Andrew J.; Gillmore, Jason G..

The authors report the detailed synthesis and photochem. of two analogs (specifically 3,5-di-tert-butyl-7′-methyl- and 3,5-di-tert-butyl-7′,9′-dimethyl-1′,3′-dihydrospirocyclohexa[2,5]diene-1,2′-pyrido[4,3,2-de]quinazolin-4-one) of the perimidinespirohexadienone (3,5-di-tert-butyl-1′,3′-dihydrospirocyclohexa[2,5]diene-1,2′-perimidin-4-one) family of photochromes in which the naphthalene moiety of the parent is replaced by a quinoline, and compare them to the parent compound Molar absorptivities of both the short wavelength spirocyclic isomer (SW) and long wavelength quinonimine isomer (LW) of each were determined by a combination of proton NMR and UV-vis spectroscopy in solvents of varying polarity. Quantum yield measurements for photoisomerization of SW to LW are reported in those same solvents, with qual. extrapolation to addnl. solvents. The position and rate of the thermal equilibrium reverting LW to SW is estimated for these compounds The 9′-Me in SW (6-Me in LW) is found to be essential for complete reversion of LW to SW in the dark. Finally one-dimensional NOE NMR spectroscopy was used to conclusively determine the structure of LW for the quinoline analogs as the 4-(5-aminoquinolin-4-ylimino)-2,6-di-tert-butylcyclohexa-2,5-dienone resulting from opening toward the quinoline nitrogen, rather than the 4-(4-aminoquinolin-5-ylimino) structure that would result from spirocyclic ring opening away from the quinoline nitrogen which had been initially proposed by V.I Minkin et al. (1999) for very similar compounds

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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia