Category: 18436-73-2

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Rapid Microwave-Assisted, Solvent-Free Approach to Functionalization of 8-Methylquinolines via Rh-Catalyzed C(sp3)-H Activation, published in 2019, which mentions a compound: 18436-73-2, Name is 4-Chloro-8-methylquinoline, Molecular C10H8ClN, Electric Literature of C10H8ClN.

A microwave-assisted synthesis of aryl (quinolinyl)acetamide derivatives I [R1 = H, 6-Cl, 4-Br, etc.; R2 = 3-Me, 4-F, 4-Cl, etc.] and quinolinyl (methyl)benzamide II via Rh-catalyzed C(sp3)-H activation of 8-methylquinoline under solvent-free condition was reported. In comparison with traditional method, this reaction proceeded more efficiently with excellent yield, a broad range substrate scope and good functional group tolerance.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-Chloro-8-methylquinoline( cas:18436-73-2 ) is researched.Computed Properties of C10H8ClN.Zhu, You-Quan; He, Jing-Li; Niu, Yun-Xia; Han, Ting-Feng; Zhu, Kun published the article 《Rapid Microwave-Assisted, Solvent-Free Approach to Functionalization of 8-Methylquinolines via Rh-Catalyzed C(sp3)-H Activation》 about this compound( cas:18436-73-2 ) in ChemistrySelect. Keywords: aryl quinolinyl acetamide preparation; methylquinoline phenyl isocyanate microwave assisted CH activation; quinolinyl methyl benzamide preparation; phenyl dioxazolone methylquinoline microwave assisted CH activation. Let’s learn more about this compound (cas:18436-73-2).

A microwave-assisted synthesis of aryl (quinolinyl)acetamide derivatives I [R1 = H, 6-Cl, 4-Br, etc.; R2 = 3-Me, 4-F, 4-Cl, etc.] and quinolinyl (methyl)benzamide II via Rh-catalyzed C(sp3)-H activation of 8-methylquinoline under solvent-free condition was reported. In comparison with traditional method, this reaction proceeded more efficiently with excellent yield, a broad range substrate scope and good functional group tolerance.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 4-Chloro-8-methylquinoline. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 4-Chloro-8-methylquinoline, is researched, Molecular C10H8ClN, CAS is 18436-73-2, about Cp*CoIII-Catalyzed Alkylation of Primary and Secondary C(sp3)-H Bonds of 8-Alkylquinolines with Maleimides. Author is Kumar, Rakesh; Kumar, Rohit; Chandra, Devesh; Sharma, Upendra.

The cobalt(III)-catalyzed C(sp3)-H bond alkylation of 8-Me quinoline with maleimides is reported. In contrast to the rhodium-catalyzed method, in the current cobalt-catalyzed method, a catalytic amount of acid is used, and importantly, it is also applicable to secondary C(sp3)-H bond alkylation. The developed methodol. is applicable for N-alkyl- and N-aryl-substituted maleimides and unsubstituted maleimides, and it also tolerates the variety of functional groups on the 8-Me quinoline moiety. Atom-economy and high regioselectivity with good to excellent yields of the alkylated products under mild reaction conditions are important features of this method.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Khan, Misbahul Ain; Ferreira de Rocha, Joao researched the compound: 4-Chloro-8-methylquinoline( cas:18436-73-2 ).Reference of 4-Chloro-8-methylquinoline.They published the article 《Tricyclic heteroaromatic ring systems. II. A convenient synthesis of 1H-pyrrolo[3,2-c]quinolines》 about this compound( cas:18436-73-2 ) in Journal of Heterocyclic Chemistry. Keywords: pyrroloquinoline; quinolinyl hydrazone cyclization. We’ll tell you more about this compound (cas:18436-73-2).

Quinol-4-yl hydrazones I (R = H, Me, Et; R1 = Me, Ph, Et; RR1 = (CH2)n, n = 3, 4; R2 = H, Me; R3 = H, 6-, 7-, 8-Cl, 6-, 7-, 8-Me, 6-, 7-, 8-MeO) on heating in high boiling solvents undergo cyclizations to give 1H-pyrrolo[3,2-c]quinolines II in good yields. Some of these I were alkylated to provide their N-alkyl derivatives

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Pyrimidine – Wikipedia

Birkinshaw, Timothy N.; Teague, Simon J.; Beech, Claire; Bonnert, Roger V.; Hill, Stephen; Patel, Anil; Reakes, Sara; Sanganee, Hitesh; Dougall, Iain G.; Phillips, Tim T.; Salter, Sylvia; Schmidt, Jerzy; Arrowsmith, Elizabeth C.; Carrillo, Juan J.; Bell, Fiona M.; Paine, Stuart W.; Weaver, Richard published an article about the compound: 4-Chloro-8-methylquinoline( cas:18436-73-2,SMILESS:CC1=C2N=CC=C(Cl)C2=CC=C1 ).Computed Properties of C10H8ClN. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:18436-73-2) through the article.

Starting with the weak agonist indomethacin, a series of potent, selective CRTh2(DP2) antagonists have been discovered as potential treatments for asthma, allergic rhinitis and other inflammatory diseases.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia