Reference of 185040-32-8 ,Some common heterocyclic compound, 185040-32-8, molecular formula is C7H9N3OS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Step 4: 6-(2-Chlorophenyl)-8-methyI-2-methylthio-8H-pyrido[2,3-d]pyrimidin-7-one; To a solution of the compound obtained from step-3 above (3.2 g, 17.7 mmol) in N-methylpyrrolidinone (20 ml) was added potassium carbonate (7.4 g, 53.04 mmol) and stirred at room temperature for 10 minutes. To it 2-chlorophenylacetic acid methyl ester (4.9 g, 26.6 mmol) was added and the reaction mixture was subsequently heated at 110 C for 2 hours. The reaction mixture was diluted with ethyl acetate and poured into water. It was then extracted with ethyl acetate, washed with water, dried over anhydrous sodium sulphate, filtered and evaporated under reduced pressure. The residue thus obtained was purified by column chromatography using ethyl acetate in hexane (1 :3) as solvent of elution to furnish the title compound. Yield: 3.2 g.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 185040-32-8, 4-(Methylamino)-2-(methylthio)pyrimidine-5-carbaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; RANBAXY LABORATORIES LIMITED; WO2008/78249; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia