Category: 18592-13-7

Recommanded Product: 18592-13-7In 1989, Naguib, Fardos N. M.;El Kouni, Mahmoud H.;Cha, Sungman published 《Structure-activity relationship of ligands of dihydrouracil dehydrogenase from mouse liver》. 《Biochemical Pharmacology》published the findings. The article contains the following contents:

One hundred and five nucleobase analogs were screened as inhibitors of dihydrouracil dehydrogenase (DHUDase, EC 1.3.1.2) from mouse liver. 5-Benzyloxybenzyluracil, 1-deazauracil (2,6-pyridinediol), 3-deazauracil (2,4-pyridinediol), 5-benzyluracil, 5-nitrobarbituric acid and 5,6-dioxyuracil (alloxan) were identified as potent inhibitors of this activity, with apparent K_i values of 0.2, 0.5, 2.1, 3.4, 3.8 and 6.6 μM resp. Both 5-benzyloxybenzyluracil and 1-deazauracil were also potent inhibitors of DHUDase from human livers. These findings along with an extensive review of literature allowed the formulation of a structure-activity relationship. The binding to DHUDase required intact C2 and C4 oxo groups. Replacement of N1 or N3 by an endocyclic carbon enhanced binding. In contrast, replacement of C5 or C6 by an endocyclic nitrogen abolished binding. Addition of a charged group to C5 and/or C6, and of a hydrophobic group to C5 but not C6 improved the binding. To complete the study, the researchers used 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7) .

6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7 Recommanded Product: 18592-13-7) was used in the synthesis of: 5-bromo-6-(chloromethyl)uracil, pteridine compounds, potential anticancer agents, substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Mather, Brian D.;Lizotte, Jeremy R.;Long, Timothy E. published 《Synthesis of Chain End Functionalized Multiple Hydrogen Bonded Polystyrenes and Poly(alkyl acrylates) Using Controlled Radical Polymerization》 in 2004. The article was appeared in 《Macromolecules》. They have made some progress in their research.Product Details of 18592-13-7 The article mentions the following:

Hydrogen bonding uracil functionalized polystyrenes and poly(alkyl acrylate)s were synthesized via stable free radical polymerization Quant. chain end functionalization was achieved using novel uracil containing TEMPO- and DEPN-based alkoxyamine unimol. initiators. Polymerizations were conducted at 130 °C and yielded functionalized homopolymers with narrow mol. weight distributions (M_w/M_n ∼ 1.20) and predictable mol. weights Polymerizations of both Bu acrylate and styrene using the DEPN- and TEMPO-based alkoxyamines resulted in mol. weight control over a wide range of conversions. Terminal functionalization of poly(alkyl acrylate)s with hydrogen bonding groups increased the melt viscosity at temperatures below 80 °C, which was defined as the dissociation temperature, and as expected, the viscosity approached that of the nonfunctional analogs above this temperature The hydrogen bonding effect was also evident in thermal (DSC) anal. and ¹H NMR spectroscopic investigations, and low molar mass polystyrenes exhibited glass transition temperatures that were consistent with a higher apparent molar mass. ¹H NMR spectroscopy confirmed the presence of a single hydrogen bonding group at the chain terminus, which was consistent with a well-defined initiation process for two families of novel alkoxyamines. And 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7) was used in the research process.

6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7 Product Details of 18592-13-7) was used in the synthesis of: 5-bromo-6-(chloromethyl)uracil, pteridine compounds, potential anticancer agents, substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dioneIn 1999, Singh, Chatar;Singh, S.;Pandey, Seema;Tripathi, P. K. published 《Vibrational spectra of 6-chloromethyluracil》. 《Asian Chemistry Letters》published the findings. The article contains the following contents:

Laser Raman and IR spectra of 6-(chloromethyl)uracil (I) were recorded and analyzed on the basis of C_s point-group symmetry. The absence of any O-H stretching vibration and the appearance of C=O stretching modes as strong bends in the spectra of I suggest that no tautomerism occurs, and the compound exists in the ketone form. The experimental procedure involved many compounds, such as 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7) .

6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7 Reference of 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione) was used in the synthesis of: 5-bromo-6-(chloromethyl)uracil, pteridine compounds, potential anticancer agents, substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application In Synthesis of 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione《Some novel piperidine analogues having strong alpha glucosidase inhibition》 was published in 2018. The authors were Rafiq, Kiran;Saify, Zafar Saied;Nesar, Shagufta;Faiyaz, Ambreen;Muhammad, Iyad Naeem, and the article was included in《Pakistan Journal of Pharmaceutical Sciences》. The author mentioned the following in the article:

In the present work some hydroxy piperidine analogs have been synthesized and analyzed for their hypoglycemic effect through glucosidase inhibition owing to the structural resemblance with nojirimycin. The activity was done by spectral absorbance anal. using acarbose as standard Two analogs 1-(1”-phenoxypropyl)-4-phenyl-4-hydroxy piperidinium hydrobromide and 1-(1”-adamantan acyl)-4-(4′-bromophenyl)-4-hydroxy piperidinium hydrobromide were found to pose excellent activity having 87.4 and 54.7% inhibition resp., hence strengthening the idea of studying piperidine analogs as glucosidase inhibitors due to structural similarity with nojirimycin. The experimental procedure involved many compounds, such as 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7) .

6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7 Application In Synthesis of 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione) was used in the synthesis of: 5-bromo-6-(chloromethyl)uracil, pteridine compounds, potential anticancer agents, substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Wade, James J. published 《Synthesis of imidazo[1,5-c]pyrimidine derivatives》. The research results were published in《Journal of Heterocyclic Chemistry》 in 1986.Computed Properties of C5H5ClN2O2 The article conveys some information:

Two complementary procedures, each starting from 6-(aminomethyl)uracil (I), were used to prepare imidazopyrimidines II (R = H, Me, Pr, CHMe₂, CMe₃, Ph; R¹ = morpholino, OMe, SPr, Me). I was prepared by ammoxidation of 6-(chloromethyl)uracil. In the first procedure, I was acylated and then cyclodehydrated by reaction with POCl₃ to give a separable mixture of II and III (R¹ = Cl). The relative product distribution is subject to some control by the choice of the acyl substituent on the starting uracil. II (R¹ = Cl) were derivatized by reaction at the 5-position with various nucleophiles, although the 7-chloro substituent is unreactive. An alternative synthetic method proceeds from I in six steps, i.e. protection as the phthalimide, chlorination, nucleophilic substitution, deprotection, acylation, and cyclodehydration, to give II (R¹ = SMe). These compounds were also derivatized by nucleophilic substitution at the 5-position.6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7) were involved in the experimental procedure.

6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7 Computed Properties of C5H5ClN2O2) was used in the synthesis of: 5-bromo-6-(chloromethyl)uracil, pteridine compounds, potential anticancer agents, substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Cusack, Lucy;Rao, S. Nagaraja;Fitzmaurice, Donald published 《Heterosupramolecular chemistry: self-assembly of an electron donor (TiO₂ nanocrystallite)-acceptor (viologen) complex》. The research results were published in《Chemistry – A European Journal》 in 1997.Related Products of 18592-13-7 The article conveys some information:

A TiO₂ nanocrystallite has been modified to recognize and selectively bind, by complementary hydrogen bonding, a uracil substrate incorporating a viologen moiety. Band-gap excitation of the self-assembled donor (TiO₂ nanocrystallite)-acceptor (viologen) complex results in electron transfer. Some implications of these findings for the self-assembly of functional nanostructures containing both condensed phase and mol. components are considered. To complete the study, the researchers used 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7) .

6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7 Related Products of 18592-13-7) was used in the synthesis of: 5-bromo-6-(chloromethyl)uracil, pteridine compounds, potential anticancer agents, substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Liu, Houmei;Guo, Yong;Wang, Xusheng;Liang, Xiaojing;Liu, Xia;Jiang, Shengxiang published 《A novel fullerene oxide functionalized silica composite as stationary phase for high performance liquid chromatography》. The research results were published in《RSC Advances》 in 2014.SDS of cas: 18592-13-7 The article conveys some information:

Hydrophilic interaction liquid chromatog. has been widely used for separating hydrophilic compounds and the development of new stationary phases for HILIC is significant. In this study, fullerene oxide was successfully assembled onto silica microspheres to form a FO-modified silica stationary phase. The synthesized material was characterized by elemental anal., transmission electron microscopy, Raman spectroscopy and contact angle anal. The chromatog. properties of the stationary phase were investigated in HILIC mode for anal. of nucleosides, nucleobases, water soluble vitamins, amino acids and saccharides. Good separations of these compounds were achieved on the resulting column. Compared with the aminopropylated silica column, FO/SiO₂ column exhibited better separation efficiency. This study also investigated the effect of various exptl. factors on the retention of the polar stationary phases, such as acetonitrile content and salt concentration in the mobile phase.6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7) were involved in the experimental procedure.

6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7 SDS of cas: 18592-13-7) was used in the synthesis of: 5-bromo-6-(chloromethyl)uracil, pteridine compounds, potential anticancer agents, substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Crigg, Ronald;Myers, Peter;Somasunderam, Anoma;Sridharan, Visuvanathar published 《X:Y-ZH systems as potential 1,3-dipoles. Part 36. 1,5-Electrocyclization processes via oxidation of tertiary amines. Pyrrolodihydroisoquinolines and -dihydro-β-carbolines》. The research results were published in《Tetrahedron》 in 1992.Electric Literature of C5H5ClN2O2 The article conveys some information:

A range of tertiary N-allylamines, e.g. I, derived from 1,2,3,4-tetrahydroisoquinoline undergo oxidative cyclization induced by Ag₂CO₃ to give pyrrolodihydroisoquinolines, e.g., II, in moderate to good yield. Analogous oxidative cyclizations are reported for N-allyltetrahydro-β-carbolines and a pyrrolidine. The reactions proceed via formation of a 1,5-dipole followed by an electrocyclization and subsequent aromatization. And 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7) was used in the research process.

6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7 Electric Literature of C5H5ClN2O2) was used in the synthesis of: 5-bromo-6-(chloromethyl)uracil, pteridine compounds, potential anticancer agents, substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Hansen, Steen Uldall;Bols, Mikael published 《1-Azaribofuranoside analogs as designed inhibitors of purine nucleoside phosphorylase. Synthesis and biological evaluation》. The research results were published in《Acta Chemica Scandinavica》 in 1998.Name: 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione The article conveys some information:

Pyrrolidine analogs of 2-deoxyribofuranose, having nitrogen in place of anomeric carbon, have been synthesized as potential transition state analogs of enzymic nucleoside cleavage. Efficient synthetic methods were developed that allowed the synthesis of a wide range of 4-substituted 3-hydroxypyrrolidines starting from pyrroline and using opening of the pyrrolidine 3,4-epoxide with carbon nucleophiles. Among the compounds synthesized were the 4-cyano-, 4-hydroxymethyl and 4-carboxymethyl derivatives From the hydroxymethyl derivative, N-alkylation with chloromethyluracil gave an inosine analog. The new compounds were tested for inhibition of human erythrocyte purine nucleoside phosphorylase. Furthermore, a solid-phase synthesis of 1′-azanucleoside analogs was developed.6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7) were involved in the experimental procedure.

6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7 Name: 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione) was used in the synthesis of: 5-bromo-6-(chloromethyl)uracil, pteridine compounds, potential anticancer agents, substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Niedzwicki, John G.;Iltzsch, Max H.;El Kouni, Mahmoud H.;Cha, Sungman published 《Structure-activity relationship of pyrimidine base analogs as ligands of orotate phosphoribosyltransferase》 in 1984. The article was appeared in 《Biochemical Pharmacology》. They have made some progress in their research.Name: 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione The article mentions the following:

Eighty pyrimidine base analogs were evaluated as inhibitors of mouse liver orotate phosphoribosyltransferase (I) (EC 2.4.2.10). Based on these findings and an extensive literature review, a structure-activity relation was formulated for the binding of pyrimidine base analogs to I. A basis for the rational design of new inhibitors of I is provided, and several such compounds are proposed. Addnl., 4,6-dihydroxypyrimidine was found to be a potent I inhibitor. Eleven I inhibitors were also evaluated as inhibitors of orotidine 5′-monophosphate decarboxylase (II) (EC 4.1.2.23). 5-Azauracil, 5-azaorotate, and barbituric acid inhibited II significantly after preincubation with PRPP and MgCl₂ in the presence of cytosol.6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7) were involved in the experimental procedure.

6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7 Name: 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione) was used in the synthesis of: 5-bromo-6-(chloromethyl)uracil, pteridine compounds, potential anticancer agents, substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia