Category: 19030-75-2

Felczak, Krzysztof published the artcileSynthesis of novel acyclo 6-(phenylseleno)uracils – potential selective anti-HIV agents, Synthetic Route of 19030-75-2, the main research area is phenylseleno uracil preparation virucide HIV.

Starting from 5-propyluracil regioselective syntheses of 1-[(2-hydroxyethoxy)methyl]-6-(phenylseleno)-5-propyluracil, 1-(ethoxymethyl)-6-(phenylseleno)-5-propyluracil and 1-(benzyloxymethyl)-6-(phenylseleno)-5-propyluracil were described. The biol. and pharmacol. activity of the compounds thus prepared was not reported.

Collection Symposium Series published new progress about phenylseleno uracil preparation virucide HIV. 19030-75-2 belongs to class pyrimidines, name is 5-N-Propyluracil, and the molecular formula is C7H10N2O2, Synthetic Route of 19030-75-2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pluskota, Donata published the artcileThe facile synthesis of N(1), N(4)-dimethyl-5-substituted cytosines, Related Products of pyrimidines, the main research area is methylcytosine; cytosine alkyldimethyl.

A facile, high yield synthesis of N(1),N(4)-dimethyl-5-alkylcytosines is described. Thus chlorination of alkyluracils I (R = Me, Et, Pr, Bu) followed by substitution with NaOEt and methylation gave methylpyrimidinones II (R1 = EtO). Substitution of II (R1 = EtO) with MeNH2 gave the title compounds II (R1 = MeNH). This method is an alternative and universal route to N(1),N(4)-methylated cytosines with any 5-substituent.

Synthetic Communications published new progress about methylcytosine; cytosine alkyldimethyl. 19030-75-2 belongs to class pyrimidines, name is 5-N-Propyluracil, and the molecular formula is C7H10N2O2, Related Products of pyrimidines.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Newmark, Philip published the artcileSubstrate specificity of the dihydrouracil dehydrogenase and uridine phosphorylase of rat liver, Recommanded Product: 5-N-Propyluracil, the main research area is LIVER/metabolism; NUCLEASES/metabolism; PHOSPHORYLASES/metabolism.

Studies were conducted to determine whether unnatural pyrimidines (e.g. 5-fluorouracil) which are able to inhibit the degradation of uracil and thymine in a complete rat-liver-enzyme system were the only ones reduced by dihydrouracil dehydrogenase (I), and whether reduction of the inhibiting pyrimidines by the I was a prerequisite for inhibition. Thymine reduction was slower than that of uracil. The relative rates of reduction of 5-halagenouracils were F > Cl > Br > I, 5-iodouracil being slower than uracil and 5-fluoro-uracil faster. I reduced 2-thiouracil, 6-azamacil, and 5-aminouracil relatively slowly. 5-Hydroxyuracil and 5alkyluracils were not reduced, but were effective inhibitors of uracil and thymine degradation. Neither cytosine nor 6-methyluracil acted in either capacity.

Biochimica et Biophysica Acta published new progress about LIVER/metabolism; NUCLEASES/metabolism; PHOSPHORYLASES/metabolism. 19030-75-2 belongs to class pyrimidines, name is 5-N-Propyluracil, and the molecular formula is C7H10N2O2, Recommanded Product: 5-N-Propyluracil.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Barrett, Harold W. published the artcileSynthetic pyrimidines as inhibitors of uracil and thymine degradation by rat-liver supernatant, Related Products of pyrimidines, the main research area is CATALYSIS; EXPERIMENTAL LAB STUDY; LIVER FUNCTION; METABOLISM; NADP; OXIDOREDUCTASES; PHARMACOLOGY; PYRIMIDINES; RATS; THYMINE; URACIL.

The ability of a number of synthetic pyrimidines to inhibit degradation of uracil and thymine by rat-tissue supernatants was examined Among 9 tissues tested, only liver preparations showed significant pyrimidine-degrading activity, and among 46 compounds tested, only 5-substituted uracils, analogs of thymine, showed appreciable inhibition of pyrimidine degradation. Despite their structure, all active compounds were more effective inhibitors of uracil than of thymine degradation; similarly, uracil and thymine showed reciprocal inhibition, but thymine was considerably more effective. It was concluded that inhibition occurred only during the initial reductive step in pyrimidine degradation, that reduction of both uracil and thymine was catalyzed by the same enzyme (dihydrouracil dehydrogenase), and that inhibition resulted from substrate competition for the active site on the enzyme.

Biochimica et Biophysica Acta, Specialized Section on Nucleic Acids and Related Subjects published new progress about Liver. 19030-75-2 belongs to class pyrimidines, name is 5-N-Propyluracil, and the molecular formula is C7H10N2O2, Related Products of pyrimidines.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Garzo, G. published the artcileGas chromatographic determination of 5-alkyluracils and 5-alkyldeoxyuridines using flash methylation and glass capillary columns, Recommanded Product: 5-N-Propyluracil, the main research area is uracil uridine derivative chromatog.

A sensitive anal. method was developed for 5-alkyl-substituted deoxyuridines and their main metabolites, the corresponding uracils in body fluids. The compound to be determined was methylated by the “”flash”” methylation technique, i.e., by injecting a mixture of the compounds and trimethylanilinium hydroxide (TMAH) into the hot injector of a gas chromatograph, followed by separation of the derivatives with a suitably deactivated glass capillary column. The optimal conditions for methylation were found by studying the effect of injector temperature, residence time, and TMAH/compound molar ratio on the yield of the reaction. The optimal residence time of the sample in the injector could be set by a “”semi-splitless”” injection method.

Journal of Chromatography published new progress about Body fluid. 19030-75-2 belongs to class pyrimidines, name is 5-N-Propyluracil, and the molecular formula is C7H10N2O2, Recommanded Product: 5-N-Propyluracil.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Strekowski, L. published the artcileNucleotide analogs. Alkylation of 2,4-dioxopyrimidine derivatives with Mannich bases, Quality Control of 19030-75-2, the main research area is alkylation uracil thymine; uracil alkylation Mannich base; thymine alkylation Mannich base; Mannich base uracil alkylation.

Alkylation of I (R1 = H, Me, Et, Pr, Bu, Br, F, R2 = H) with the Mannich bases R2NMe2 (R2 = PhCOCH2CH2, 3-indolylmethyl) gave the N-1-monoalkylated derivatives in 11-80% yields. Condensation of thymine with 2,3-(HO)MeC6H3CH2NMe2 gave both the N-3-mono and N-1,N-3-disubstituted derivatives

Prace Wydzialu Matematyki, Fizyki i Chemii, Uniwersytet im. Adama Mickiewicza w Poznaniu, Seria: Chemia published new progress about Alkylation. 19030-75-2 belongs to class pyrimidines, name is 5-N-Propyluracil, and the molecular formula is C7H10N2O2, Quality Control of 19030-75-2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Iltzsch, Max H. published the artcileStructure-activity relationship of ligands of uracil phosphoribosyltransferase from Toxoplasma gondii, Application of 5-N-Propyluracil, the main research area is structure ligand uracil phosphoribosyltransferase Toxoplasma.

One hundred compounds were evaluated as ligands of Toxoplasma gondii, uracil phosphoribosyltransferase (UPRTase, EC 2.4.2.9) by examining their ability to inhibit this enzyme in vitro. Inhibition was quantified by determining apparent Ki values fo those compounds that inhibited T. gondii UPRTase by greater than 10% at a concentration of 2 mM. Five compounds (4-thiopyridine, 2-thiopyrimidine, trihiocyanuric acid, 1-deazauracil and 2,4-dithiouracil) bound to the enzyme better than two known substrates for T. gondii UPRTase, 5-fluorouracil and emimycin, which have antitoxoplasmal activity (Pfefferkorn ER, Exp Parasitol 44: 26-35, 1978; Pfefferkorn et al., Exp Parasitol 69: 129-139, 1989). In addition, several selected compounds were evaluated as substrates for T. gondii UPRTase, and it was found that 2,4-dithiouracil is also a substrate for this enzyme. On the basis of these data, a structure-activity relationship for the binding of ligands to T. gondii UPRTase was determined using uracil as a reference compound

Biochemical Pharmacology published new progress about Protozoacides. 19030-75-2 belongs to class pyrimidines, name is 5-N-Propyluracil, and the molecular formula is C7H10N2O2, Application of 5-N-Propyluracil.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Muraoka, Masako published the artcileAlkylated pyrimidine derivatives as antiviral agents. I. Syntheses and antiviral screening of alkylpyrimidine and 5-alkyluracil nucleoside, Recommanded Product: 5-N-Propyluracil, the main research area is glucopyranosyl uracils antiviral; antiviral glucopyranosyl uracils; uracils glucopyranosyl antiviral; ribofuranosyl uracils antiviral.

5-Al-kyluracil, 3-alkyluracil, 5-alkylisocytosine, 5-alkyl-6-methylisocytosine, 3-alkyl-6-methyluracil, 1-(β-D-glucopyranosyl)-5-alkyluracil and 1-(β-D-ribofuranosyl)-5-alkyluracil were prepared and screened for antivirial activity on both RNA- and DNA-containing viruses. For RNA virus, type I Mahoney polio virus, and K-2211 strain ECHO-28 virus were used. For DNA viruses, type-I and type-12 strains adeno virus and DV 96 strain vaccinia virus were used. 5-Butyluracil and 1-(β-D-ribofuranosyl)-5-butyluracil (I) were effective against both RNA and DNA viruses. I was the more effective and exerted a broader spectrum than 5-fluorodeoxyuridine.

Chemical & Pharmaceutical Bulletin published new progress about Antiviral agents. 19030-75-2 belongs to class pyrimidines, name is 5-N-Propyluracil, and the molecular formula is C7H10N2O2, Recommanded Product: 5-N-Propyluracil.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Miazga, Agnieszka published the artcileSynthesis and anti-HIV properties of novel 6-phenylselenenyl-5-propyluracils, Computed Properties of 19030-75-2, the main research area is phenylselenenylpropyluracil preparation antiHIV antiviral antiHIV antiAIDS.

Novel 6-phenylselenenyl-5-propyluracils were synthesized from 5-propyluracil with the use of regioselective synthesis to give 1-[(2-hydroxyethoxy)methyl]-6-phenylselenenyl-5-propyluracil (6), 1-ethoxymethyl-6-phenylselenenyl-5-propyluracil (9) and 1-benzyloxymethyl-6-phenylselenenyl-5-propyluracil (10). Interaction of these compounds with recombinant HIV-1 reverse transcriptase (RT) was evaluated using a non-isotopic colorimetric method. Compounds 9 and 10 exerted potent HIV RT inhibition (IC50 = 0.06 and 0.05 μM resp.) while compound 6 showed moderate inhibition (IC50 = 3.5 μM). Potent anti-HIV-1 activity in MT-2 cells inoculated by a syncythia-inducing HIV-1 (cat #3 strain) laboratory isolate was exerted by compounds 9 and 10 (EC50 = 0.62 μM and 0.025 μM, resp.), while compound 6 showed only moderate activity (IC50 = 4.1 μM). In addition, compound 10 showed very good in vitro therapeutic index (TI > 2046), indicating that it is a potential anti-HIV/AIDS drug.

Acta Biochimica Polonica published new progress about AIDS (disease). 19030-75-2 belongs to class pyrimidines, name is 5-N-Propyluracil, and the molecular formula is C7H10N2O2, Computed Properties of 19030-75-2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Iltzsch, Max H. published the artcileStructure-activity relationship of nucleobase ligands of uridine phosphorylase from Toxoplasma gondii, HPLC of Formula: 19030-75-2, the main research area is pyrimidine base Toxoplasma uridine phosphorylase inhibition; structure uracil analog uridine phosphorylase inhibition.

Seventy-nine nucleobase analogs were evaluated as potential inhibitors of T. gondii uridine phosphorylase (UrdPase), and the apparent Ki (appKi) values for these compounds were determined Based on the inhibition data, a structure-activity relationship for the binding of nucleobase analogs to the enzyme was formulated, using uracil as a reference compound Two compounds were identified as very potent inhibitors of T. gondii UrdPase: 5-benzyloxybenzylbarbituric acid and 5-benzyloxybenzyluracil, which had appKi values of 0.32 and 2.5 μM, resp. A comparison of the results from the present study with those from similar studies on mammalian UrdPase and thymidine phosphorylase (dThdPase) revealed that there are both similarities and differences between the catalytic site of T. gondii UrdPase and the catalytic sites of the mammalian enzymes with respect to binding of uracil analogs. One compound, 6-benzyl-2-thiouracil, was identified as a potent, specific inhibitor (appKi = 14 μM) of T. gondii UrdPase, relative to mammalian UrdPase and dThdPase.

Biochemical Pharmacology published new progress about Enzyme kinetics. 19030-75-2 belongs to class pyrimidines, name is 5-N-Propyluracil, and the molecular formula is C7H10N2O2, HPLC of Formula: 19030-75-2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia