Adding a certain compound to certain chemical reactions, such as: 19178-25-7, Pyrido[3,4-d]pyrimidin-4(3H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 19178-25-7, blongs to pyrimidines compound. SDS of cas: 19178-25-7
A suspension of pyrido[3,4-d]pyrimidin-4-ol (33)(1.47 g, 10 mmol) in thionylchloride (30 ml) and dimethylformamide (50 mul, cat.) was heated to reflx (90 C.) for 1 hour. The mixture was then cooled and concentrated in vacuo and then diluted with CH2Cl2 (50 ml) which caused a suspension to form. The solid was removed by filtration, washed with cold CH2Cl2 (10 ml) to give the title compound (1.65 g, 99.4%) in sufficiently pure form to be used without any further purification. m/z (LC-MS, ESP): 166 [M+H]+, R/T=2.82 mins.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19178-25-7, its application will become more common.
Reference:
Patent; Kudos Pharmaceuticals Ltd; US2006/199804; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia